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The Controlled Release Of Neurotrophic Proteins From The Conducting Polymer Polypyrrole To Improve The Nerve/Cochlear Implant Interface, Brianna C. Thompson
The Controlled Release Of Neurotrophic Proteins From The Conducting Polymer Polypyrrole To Improve The Nerve/Cochlear Implant Interface, Brianna C. Thompson
University of Wollongong Thesis Collection 1954-2016
The cochlear implant has restored hearing to hundreds of thousands of profoundly deaf individuals since the early 1980s. The implant works by providing electrical stimulation directly to the auditory nerves, bypassing the damaged sensory processes. As the electrodes of the cochlear implant are required to directly stimulate the auditory nerves, the interface between these electrodes and the nervous system is a vital part of the function of the bionic device. However, in cases of long-term hearing loss the auditory nerve degenerates and auditory nerve processes, or neurites, retract away from the cochlea and the intra-cochlear electrodes. This leads to a …
Development Of Novel Nanostructured Conducting Polypyrrole Fibres, Javad Foroughi
Development Of Novel Nanostructured Conducting Polypyrrole Fibres, Javad Foroughi
University of Wollongong Thesis Collection 1954-2016
Polypyrrole (PPy) as a conducting polymer has potential applications in electrical and electronic devices because of its high electrical conductivity, environmental stability and redox activity. There have been many attempts to endow electrically PPy with processibility. Although some success has been achieved via synthesising soluble PPy, there have remained difficulties to fabricate this material through fibre spinning due to its low molecular weight and poor mechanical properties. Prior to this thesis, there was no report of the production of PPy fibres. This project therefore aimed to produce novel “polypyrrole fibres via the development of nanostructured conducting polypyrrole” by fibre spinning …
Effective Control Of Cell Behavior On Conducting Polymers, Xiao Liu
Effective Control Of Cell Behavior On Conducting Polymers, Xiao Liu
University of Wollongong Thesis Collection 1954-2016
This study explored the potential biomedical applications of polypyrrole (PPy). Electrical and topographic cues have been delivered to cells via composites of these conducting polymers, resulting in the successful control of cell behaviour. It was found that a clinically-relevant electrical stimulation protocol (250 Hz biphasic pulsed-current) delivered directly via PPy/poly(2-methoxy-5-aniline sulfonic acid) (PMAS) films can significantly promote PC12 nerve cell differentiation in the presence of nerve growth factor (NGF), and can initiate reversible neurite sprouting from PC12 cell in the absence of NGF. The ability to promote neural outgrowth on PPy/PMAS has important implications for improving the neural/electrode interface, and …