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Moving Forward With Ketamine Therapy: Ensuring Safety, Efficacy, And Accessibility In Depression Treatment, Julienne Desanto

Undergraduate Honors Theses

Ketamine, a medication long used in anesthesia, has emerged as a promising treatment for depression and other mental health disorders. Its rapid onset of action and mechanism, which differs from traditional antidepressants by targeting NMDA receptors, offers a novel approach to managing depressive symptoms. Despite its potential, ketamine's use outside anesthesia, particularly in off-label ketamine clinics, is fraught with regulatory, safety, and accessibility challenges. This paper explores the historical medical use of ketamine and its emerging role in mental health treatment. It compares the efficacies and administration routes of different forms of ketamine, including intravenous (IV) and intranasal (nasal spray) …

The Mediation Of Mental Health Between Adverse Childhood Experiences And Risky Sexual Behavior, Kayla Marie Mandrigues, Julia Claire Dodd, Stacey Lynne Williams

Undergraduate Honors Theses

Risky sexual behaviors (RSB) have the potential to negatively impact individuals by increasing the risk of mental health issues, sexually transmitted infections (STIs), and unwanted pregnancies. Adverse childhood experiences (ACEs) and mental health disorders, such as anxiety, PTSD, and depression, have been known to increase RSB. The purpose of this study was to see if these mental health disorders mediate the relationship between ACEs and RSB. Participants (n = 342, mean age = 32) were recruited through social media to complete an online questionnaire. While history of ACEs significantly predicted engagement in RSB as well as all three of the …

Main And Interactive Effects Of Mental Health, Parent Ethnic Socialization, Discrimination On Bipoc Teens' Ethnic Identity, Emily Takamasa, Ashley M. Fraser, Adam Rogers

Undergraduate Honors Theses

Research would suggest that BIPOC (Black, Indigenous, People of Color) adolescents have the best developmental outcomes when strong, positive ethnic identity is acknowledged and embraced. This study investigated whether discrimination, internalizing symptomology, parent socialization, and/or interactions of these variables influenced adolescent ethnic identity, specifically in exploration, resolution, and affirmation to illuminate nuanced ways BIPOC youth can achieve positive ethnic identity. Recruited from third-party research panels, surveyed participants were adolescents (Mage = 15.28; 51.6% male) of diverse racial/ethnic groups and socioeconomic backgrounds from all regions of the U.S. Overall, the results showed that there were four significant main effects on ethnic …

The Effects Of The Transition From Pre-Nursing To Nursing On Mental Health, Andrew J. Davis, Paige R. Mullins, Kimberly A. Sell

Undergraduate Honors Theses

Mental health is an ever-growing crisis among adolescents and young adults, with suicide as second leading cause of death and the number of those negatively affected continually on the rise. Transitions are one of the major stressors prevalent among these age groups, placing individuals at risk for mental health deficits. This quantitative voluntary response comparative study assesses the transitional mental health of pre-nursing students and students in the nursing program at East Tennessee State University. Emailed to all with a declared major of pre-nursing or nursing, this study measured mental health using evidenced based assessment tools. The PHQ-9 for depression …

Making The Case For Psychedelics: Comparing Alternative Treatment Options For Depression, Nicole Amavisca

Undergraduate Honors Theses

Given the number of people who are treated for depression each year and the knowledge that treatments work differently for everyone, there is a pressing need to provide a variety of treatment options. Although psychedelic research had been halted for a few decades due to recreational abuse, there has been revived interest due to its therapeutic potential in the treatment of mood disorders and addiction. As an example, the hallucinogen ketamine has recently been approved as a treatment for depression, which has opened the door for broadening the discussion on psychedelic research. Although the research is limited, psilocybin mimics ketamine …

Psychological Distress And Susceptibility To Disease In The Infant And Early Childhood Mental Health (Iecmh) Workforce In The Time Of The Covid-19 Pandemic, Ashley Sexton

Undergraduate Honors Theses

Chronic stress, anxiety, and depression can have many adverse effects on physical health, including immunosuppression and increased susceptibility to disease. For the last year, the world has endured sustained stress caused by the COVID-19 pandemic which has had its own impact on mental health. Stress from COVID-19 will likely have an even greater impact on the Infant and Early Childhood Mental Health (IECMH) workforce due to the stressful nature of their work. Self-care has been shown to improve overall wellbeing and act as a buffer for stress. Therefore, the current study aims to investigate if IECMH workers with clinically significant …

Effect Of A Self-Care And Self-Awareness Education Program On Resilience To Burnout And Depression In Clinically Experienced Nursing Students, Andrew Taylor

Undergraduate Honors Theses

The purpose was to examine the effect of a self-care educational intervention on nursing student resilience and thus the potential for compassion fatigue, depersonalization, burnout, depression, and inadequate self-care. A one-group pretest-posttest research design was applied to a convenience sample of 104 nursing students near the end of their last semester in a baccalaureate nursing program. The measurements were demographics, a psychometric resilience scale, program evaluation, and reflection question. The intervention was a standardized, intensive 30 min training program on the high degree of stress and burnout nurses face and the core self-care methods that can promote resilience to these …

Validating The Collegiate Optimism Orientation Test And Exploring Its Correlation To Gpa And Mental Health Among College Students, Emilia Bingham

Undergraduate Honors Theses

The Collegiate Optimism Orientation Test (COOT) was designed to provide a more specific and accurate understanding of an individual’s optimism in a collegiate setting. The current study investigates the reliability and validity of the COOT in order to demonstrate its usefulness as a measure of optimism in college students and examines the relationship between optimism and both mental health and GPA. Participants were gathered using online survey websites, one of which was specific for students at Brigham Young University specifically and the other of which was open to any college student in the United States. Participants took a survey consisting …

Investigating The Eeg Error-Related Negativity In College Students With Adhd, Anxiety, And Depression, Mariacristina Canini

Undergraduate Honors Theses

Error-related negativity (ERN) is an event-related potential elicited by the commission of errors. It appears as a negative deflection peaking between 50ms and 100ms after an erroneous response. Previous literature demonstrated that individuals who suffer from either anxiety or depression display a higher ERN amplitude compared to a control group. It has also been shown that people with ADHD display a lower ERN amplitude. Based on these findings, we investigated the relationships between these three disorders and their effects on the amplitude of the ERN. We recruited thirty-one students at East Tennessee State University and gathered data on their level …

Internalizing Symptoms Associated With Emotional Abuse: An Examination Of Religious Social Support As A Moderating Variable, Jessica Chambers, Diana Morelen, Jason Steadman, Michelle Hurley

Undergraduate Honors Theses

Emotional abuse in childhood is linked to an increased risk for internalizing symptoms such as depression and anxiety in adulthood. Religious social support offers a promising defense in maintaining mental well-being in the face of trauma. This study aims to investigate if religious social support in childhood will moderate the impact of negative outcomes associated with emotional abuse. Further, this study will examine whether and how gender and ethnicity impact this relationship. The sample includes undergraduate students attending East Tennessee State University, located in the southeastern United States (n = 471, 73% female, 11% African American, M age = 20.37, …

Life In The Lgbtq+ Community: Protective Factors Against Depression In The Community And In Everyday Life, Kristen Paris

Undergraduate Honors Theses

Abstract

In this study, we examined potential protective factors against depression in the LGBTQ+ community by determining whether outness, self-esteem, perceived social support, life meaning, courage to challenge or resilience/hardiness, life satisfaction, and hope were correlated with less depression. There were 149 participants in the study, 38 of whom identified as members of the LGBTQ+ community, and 107 of whom identified as heterosexual. Participants completed an online survey that took approximately 30 minutes. It was predicted that protective factors would be negatively related to depression. Results of both correlation and regression analyses revealed no significant relations between protective factors and …

Perceived Stress And Suicidal Behaviors In College Students: Conditional Indirect Effects Of Depressive Symptoms And Mental Health Stigma, Esther Reynolds

Undergraduate Honors Theses

Suicide is the second leading cause of death in college students, making it a significant public health concern on college campuses. Perceived stress, depression, and mental health stigma are established risk factors for engaging in suicidal behaviors; however, their interrelationships are unknown. In a sample of 913 college students, we examined the role of depressive symptoms as a potential mediator of the relation between stress and suicidal behavior, and mental health stigma as a moderator of that effect. In bivariate analyses, perceived stress, depressive symptoms, mental health stigma and suicidal behaviors were all positively correlated. Additionally, depressive symptoms partially mediated …

Locus Coeruleus And Hippocampal Tyrosine Hydroxylase Levels In A Pressure-Overload Model Of Heart Disease, Luke A. Johnson

Undergraduate Honors Theses

Studies have indicated that approximately 30% of people with heart disease experience major depressive disorder (MDD). Despite strong clinical evidence of a link between the two diseases, the neurobiological processes involved in the relationship are poorly understood. A growing number of studies are revealing similar neuroanatomical and neurochemical abnormalities resulting from both depression and heart disease. The locus coeruleus (LC) is a group of neurons in the pons that synthesize and release norepinephrine, and that is known to play a significant role in depression pathobiology. For example, there is evidence that tyrosine hydroxylase (TH) is elevated in the LC in …