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Genetic And Environmental Interactions On Schizophrenia-Like Phenotypes In Chl1 Deficient Mice, J. Daniel Obray
Genetic And Environmental Interactions On Schizophrenia-Like Phenotypes In Chl1 Deficient Mice, J. Daniel Obray
Undergraduate Honors Capstone Projects
Schizophrenia is a debilitating disorder which is often characterized by dysregulation of the processing of sensory information. Schizophrenia has been shown to have a strong genetic component, as well as a strong environmental component. As such, a number of hypotheses such as the diathesis stress hypothesis have been developed to explain the etiology of schizophrenia. As most of these theories attempt to account for a genetic and an environmental factor, they are often viewed as double-hit models of schizophrenia. Several theories have emerged as potential explanations for the symptoms of schizophrenia. The dopamine hypothesis suggests that the basal level of …
Investigating The Pathogenecity Of Chl1 Leu17phe Polymorphism In Schizophrenia, Brooke Nichole Hansen
Investigating The Pathogenecity Of Chl1 Leu17phe Polymorphism In Schizophrenia, Brooke Nichole Hansen
Undergraduate Honors Capstone Projects
Schizophrenia is a devastating brain disorder that affects a surprising 1% of the world's population. Despite this prevalence, little is known about the molecular aspects of this disorder making it both difficult to diagnose and treat. Several studies have identified the CHL1 gene (Close Homolog of L1), sometimes referred to as CALL, as a risk gene for schizophrenia. CHL1, a neural cell adhesion molecule, has major roles in cell migration, and the development of dendritic and axonal projections. Therefore any deficiency in CHL1 may result in brain defects similar to those identified in schizophrenic populations. Moreover, in genetically engineered mice, …