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Moderation Analysis Of Bowel Function Among Nutrients And Physical Function Or Depression, As Well As Whether Bowel Function Is Related To Cognition In Older Adults, Jessie Alwerdt
USF Tampa Graduate Theses and Dissertations
As we age, the risk for gut issues, such as smooth muscle tone, may be an underlying indirect or direct cause or risk factor for many age-related issues, such as frailty. Consequences of decreased motility and depleted epithelial barrier may result in nutrient deficiencies that may increase the risk for malnutrition (Brownie, 2006). Further, there is increasing evidence that there is a gut-brain-axis relationship that may influence cognition and mental health issues, such as depression and anxiety. While there are relationships established, the interconnections of these factors have yet to be fully understood.
This dissertation examined several relationships specific to …
Genetic Moderators Of Cognitive Decline In The Health And Retirement Study, Shannon K. Runge
Genetic Moderators Of Cognitive Decline In The Health And Retirement Study, Shannon K. Runge
USF Tampa Graduate Theses and Dissertations
The current dissertation used a gene x environment (G x E) approach to examine the independent and interactive effects of specific genetic variants and participation in physical and cognitive/social activities (PA and CSA) on cognitive performance in 4,764 participants of the Health and Retirement Study. Using three-wave data, three sets of multi-level growth models were conducted to examine baseline, longitudinal, and interactive effects of genotype (i.e., ApoE, COMT, and BDNF) and CSA/PA on performance across five cognitive measures: immediate, delayed and total word recall, and serial 7s and backwards counting.
At baseline, the ApoE ε4 allele predicted …
Metabolic Therapy For Age-Dependent Impaired Wound Healing, Shannon Lynn Kesl
Metabolic Therapy For Age-Dependent Impaired Wound Healing, Shannon Lynn Kesl
USF Tampa Graduate Theses and Dissertations
Chronic wounds represent an under-acknowledged socioeconomic epidemic, affecting 1.8 million new patients per year and costing the US health care system upwards of $25 billion annually. This substantial cost is rapidly growing due to a disproportionate occurrence in the ever-aging population. Key features associated with age-related impairment of wound healing include limited energy and nutrient exchange, unremitting inflammations, increased reactive oxygen species (ROS), and diminished blood flow. Most chronic wound therapies target specific molecular mechanisms; however, there are often multiple mitigating factors that prevent normal wound closure. This is likely one reason most wound therapies are minimally effective. In the …