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Tocilizumab And Covid-19: A Meta-Analysis Of 2120 Patients With Severe Disease Andimplications For Clinical Trial Methodologies, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Hinna Aftab, Zainab Pervaiz
Tocilizumab And Covid-19: A Meta-Analysis Of 2120 Patients With Severe Disease Andimplications For Clinical Trial Methodologies, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Hinna Aftab, Zainab Pervaiz
Turkish Journal of Medical Sciences
Background/aim: Since the outbreak of the COVID-19, numerous therapies to counteract this severe disease have emerged. The benefits of Tocilizumab for severely infected COVID-19 patients and the methodologies of ongoing clinical trials are explored. Materials and methods: A systematic search adhering to PRISMA guidelines was conducted in PubMed, Cochrane Central, medRxiv, and bioRxiv using the following keywords: "Tocilizumab," "Actemra," "COVID-19." An additional subsearch was conducted on Clinicaltrials.gov to locate ongoing tocilizumab trials. Results: A total of 13 studies were included in the meta-analysis comprising 2120 patients. The treatment group had lower mortality compared to the control group (OR = 0.42, …
Treatment Of Sars-Cov-2 Pneumonia With Favipiravir: Early Results From The Egeuniversity Cohort, Turkey, Hüseyi̇n Aytaç Erdem, Pervi̇n Korkmaz Ekren, Derya Çağlayan, Meltem Taşbakan, Tansu Yamazhan, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Ayşe Deni̇z Gökengi̇n
Treatment Of Sars-Cov-2 Pneumonia With Favipiravir: Early Results From The Egeuniversity Cohort, Turkey, Hüseyi̇n Aytaç Erdem, Pervi̇n Korkmaz Ekren, Derya Çağlayan, Meltem Taşbakan, Tansu Yamazhan, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Ayşe Deni̇z Gökengi̇n
Turkish Journal of Medical Sciences
Background/aim: The aim of this descriptive article is to share the experience in Ege University, Turkey with favipiravir in the treatment of severe SARS-CoV-2 pneumonia. Materials and methods: This retrospective descriptive study included patients diagnosed with COVID-19 who presented with or developed severe pneumonia. Results: Forty patients who completed a full course (at least 5 days) of favipiravir were included in the study. At baseline, 30 (75%) patients required treatment for respiratory distress. Thirty-three patients (82.5%) were discharged from the hospital with full recovery, 6 patients (15%) died and 1 case (2.5%) was still at the intensive care unit (ICU) …
Sars-Cov-2 Associated Rhabdomyolysis In 32 Patients, Josef Finsterer, Fulvio Scorza
Sars-Cov-2 Associated Rhabdomyolysis In 32 Patients, Josef Finsterer, Fulvio Scorza
Turkish Journal of Medical Sciences
Background/aim: This mini-review aims at summarising and discussing previous and recent findings concerning the clinical manifestations, therapeutic management, and outcome of SARS-CoV-2 associated rhabdomyolysis. Materials and methods: Literature search in the PubMed database by applying appropriate search terms. Results: A total of 26 articles reporting SARS-CoV-2 associated rhabdomyolysis in 32 patients were identified. Age ranged from 16 to 80 years. Four patients were female and 25 were male. Onset of rhabdomyolysis was prior to onset of COVID-19 in 7 patients, and after onset of COVID-19 in the remaining patients. Exposure to myotoxic medication was identified in 18 patients. Myotoxic drugs …
Cadaver Versus Simulator Based Arthroscopic Training In Shoulder Surgery, Gazi̇ Huri̇, Mert Ruşen Gülşen, Ece Belen Karmiş, Doğaç Karagüven
Cadaver Versus Simulator Based Arthroscopic Training In Shoulder Surgery, Gazi̇ Huri̇, Mert Ruşen Gülşen, Ece Belen Karmiş, Doğaç Karagüven
Turkish Journal of Medical Sciences
Introduction: There are few studies that compare the cadaver dissections with the medical simulators in means of talent improvement. Therefore, the aim of this study is to find out if using cadaver dissections is still the golden standard for surgical training or using the medical simulators in surgery could replace cadaver dissections. Materials and methods: The study is conducted during the European Orthopaedics & Traumatology Education Platform accredited Shoulder Club International Cadaver Course including a number of 34 orthopedics trainees. The participants were randomly divided into two groups to be trained with the simulator (Group 1) and on cadavers (Group …