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Statistical Methods For Detecting And Characterizing Departures From Additivity In Multi-Dimensional Drug/Chemical Mixtures, Kathryn S. Dawson
Statistical Methods For Detecting And Characterizing Departures From Additivity In Multi-Dimensional Drug/Chemical Mixtures, Kathryn S. Dawson
Theses and Dissertations
In studies of the effects of multiple drug or chemical combinations, one goal may be to detect and characterize the interactions between the agents. The techniques currently applied to this problem have limitations when the experiments involve more than 2 agents. Certain response-surface techniques require an unrealistic number of observations for studies involving a large number of agents. Current graphical methods are impossible to use in studies of 3 or more agents. In this research two statistical techniques are described that can be applied to studies with an unlimited number of agents. In the first approach, dose combinations are collected …
The Role Of Follicular Dendritic Cells In Human Immunodeficiency Virus Pathogenesis, Sonya Lynn Heath
The Role Of Follicular Dendritic Cells In Human Immunodeficiency Virus Pathogenesis, Sonya Lynn Heath
Theses and Dissertations
Infection with Human Immunodeficiency Virus-1(HIV) results in a disease process characterized by three stages: an acute phase characterized by viremia, a clinically latent stage with little or no detection of virus in the blood, and the last stage, AIDS, which. is characterized. by marked immunodeficiency. During clinical latency, CD4+ T cells decline over a period lasting from a few to several years. Throughout this period, HIV is found trapped on the surface of follicular dendritic cells(FDC) in the germinal centers of secondary lymphoid tissues and this is the primary site of active viral replication. We hypothesize that FDC, and the …