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Morphological Correlates Of Mechanotransduction In Acousticolateral Hair Cells, J. O. Pickles, G. W. Rouse, M. Von Perger
Morphological Correlates Of Mechanotransduction In Acousticolateral Hair Cells, J. O. Pickles, G. W. Rouse, M. Von Perger
Scanning Microscopy
The development of ideas on mechanotransduction in acousticolateral hair cells is described, leading to the current idea that transduction depends on deflection of the bundle of stereocilia by a force parallel to the plane of the sensory epithelium. Electrophysiological experiments are summarised, suggesting that transduction depends on a shear between the different rows of stereocilia, and that the transducer channels are situated towards the tips of the stereocilia. Analysis of the ways that shear between the rows of stereocilia could be detected suggests that tip links are the structures which are most likely to transmit the stimulus-induced forces to the …