Digital Commons Network^™

Maternal Effects On Ethanol Teratogenesis In A Cross Between A/J And C57bl/6j Mice, David Gilliam, Nate Valdez, Scott Branson, Ashley Dixon, Chris Downing

SPS Faculty Publications

Genetic factors influence adverse pregnancy outcome in both humans and animal models. Animal research reveals both the maternal and fetal genetic profiles are important for determining the risk of physical birth defects and prenatal mortality. Using a reciprocal-cross breeding design, we investigated whether the mother’s genes may be more important than fetal genes in determining risk for ethanol teratogenesis. Examination of possible synergistic genetic effects on ethanol teratogenesis was made possible by using two mouse strains known to be susceptible to specific malformations. Inbred A/J (A) and C57BL/6J (B6) mice were mated to produce four fetal genotype groups: the true-bred …