Digital Commons Network^™

Biosensors For Brain Trauma And Dual Laser Doppler Flowmetry: Enoxaparin Simultaneously Reduces Stroke-Induced Dopamine And Blood Flow While Enhancing Serotonin And Blood Flow In Motor Neurons Of Brain, In Vivo, Patricia A. Broderick, Edwin H. Kolodny

Publications and Research

Neuromolecular Imaging (NMI) based on adsorptive electrochemistry, combined with Dual Laser Doppler Flowmetry (LDF) is presented herein to investigate the brain neurochemistry affected by enoxaparin (Lovenox®), an antiplatelet/antithrombotic medication for stroke victims. NMI with miniature biosensors enables neurotransmitter and neuropeptide (NT) imaging; each NT is imaged with a response time in milliseconds. A semiderivative electronic reduction circuit images several NT’s selectively and separately within a response time of minutes. Spatial resolution of NMI biosensors is in the range of nanomicrons and electrochemically-induced current ranges are in pico- and nano-amperes. Simultaneously with NMI, the LDF technology presented herein operates on line …

Arsenic Migration To Deep Groundwater In Bangladesh Influenced By Adsorption And Water Demand, K.A. Radloff, Y. Zheng, H.A. Michael, M. Stute, B. C. Bostick, I. Mihajlov, M. Bounds, M. R. Huq, I. Choudhury, M. W. Rahman, P. Schlosser, K. M. Ahmed, A. Van Geen

Publications and Research

Drinking shallow groundwater with naturally elevated concentrations of arsenic is causing widespread disease in many parts of South and Southeast Asia. In the Bengal Basin, growing reliance on deep (>150 m) groundwater has lowered exposure. In the most affected districts of Bangladesh, shallow groundwater concentrations average 100 to 370 μg L−1, while deep groundwater is typically < 10 μg L−1. Groundwater flow simulations have suggested that, even when deep pumping is restricted to domestic use, deep groundwater in some areas of the Bengal Basin is at risk of contamination. However, these simulations have neglected the impedance of As migration by adsorption to aquifer sediments. Here we quantify for the first time As sorption on deeper sediments in situ by replicating the intrusion of shallow groundwater through injection of 1,000 L of deep groundwater modified with 200 μg L−1 of As into a deeper aquifer. Arsenic concentrations in the injected water were reduced by 70% due to adsorption within a single day. Basin-scale modelling indicates that while As adsorption extends the sustainable use of deep groundwater, some areas remain vulnerable; these areas can be prioritized for management and monitoring.

The Murine Caecal Microrna Signature Depends On The Presence Of The Endogenous Microbiota, Natasha Singh, Elize A. Shirdel, Levi Waldron, Regan-Heng Zhang, Igor Jurisica, Elena M. Comelli

Publications and Research

The intestinal messenger RNA expression signature is affected by the presence and compo-sition of the endogenous microbiota, with effects on host physiology. The intestine is also characterized by a distinctive micronome. However, it is not known if microbes also impact intestinal gene expression epigenetically. We investigated if the murine caecal microRNA expression signature depends on the presence of the microbiota, and the potential implica-tions of this interaction on intestinal barrier function. Three hundred and thirty four mi-croRNAs were detectable in the caecum of germ-free and conventional male mice and 16 were differentially expressed, with samples from the two groups clustering …

Sexuality, Rights And Personhood: Tensions In A Transnational World, Dina M. Siddiqi

Publications and Research

Background This article discusses what happens when normative ‘global’ discourses of rights and individuated sexual identity confront the messiness of ‘local’ realities. It considers the tensions that emerge when the relationship between sexual and social identities is not obvious and the implications of such tensions for public health and sexual rights activism. These questions are addressed through debates over the naming of male-to-male sexualities and desires in the context of globalization and the growth of a large NGO (non-governmental organization) sector in urban Bangladesh. Methods The material in the paper draws on a research project undertaken in 2008-9 in Dhaka, …

Attention And Olfactory Consciousness, Andreas Keller

Publications and Research

Understanding the relation between attention and consciousness is an important part of our understanding of consciousness. Attention, unlike consciousness, can be systematically manipulated in psychophysical experiments and a law-like relation between attention and consciousness is waiting to be discovered. Most attempts to discover the nature of this relation are focused on a special type of attention: spatial visual attention. In this review I want to introduce another type of attention to the discussion: attention to the olfactory modality. I will first clarify the position of attention to smells in a general taxonomy of attention. I will then review the mechanisms …

The Evolution And Diversity Of Dna Transposons In The Genome Of The Lizard Anolis Carolinensis, Peter A. Novick, Jeremy D. Smith, Mark Floumanhaft, David A. Ray, Stéphane Boissinot

Publications and Research

DNA transposons have considerably affected the size and structure of eukaryotic genomes and have been an important source of evolutionary novelties. In vertebrates, DNA transposons are discontinuously distributed due to the frequent extinction and recolonization of these genomes by active elements. We performed a detailed analysis of the DNA transposons in the genome of the lizard Anolis carolinensis, the first non-avian reptile to have its genome sequenced. Elements belonging to six of the previously recognized superfamilies of elements (hAT, Tc1/Mariner, Helitron, PIF/Harbinger, Polinton/Maverick, and Chapaev) were identified. However, only four (hAT, Tc1/Mariner, Helitron, and Chapaev) of these superfamilies have successfully …

Comparison And Correlates Of Three Preference-Based Healthrelated Quality-Of-Life Measures Among Overweight And Obese Women With Urinary Incontinence, Angela Marinilli Pinto, Miriam Kupperman, Sanae Nakagawa, Eric Vittinghoff, Rena R. Wing, John W. Kusek, William H. Herman, Leslee L. Subak

Publications and Research

PURPOSE: To compare three preference-based health-related quality-of-life (HRQL) measures and examine independent correlates of HRQL among overweight and obese women with urinary incontinence (UI) enrolled in a weight loss intervention trial.

METHODS: Participants completed baseline questionnaires, which included the Health Utilities Index 3 (HUI3) and Medical Outcomes Study Short Form-36 (SF-36). The SF-36 was used to derive SF-6D and estimated Quality of Well-Being (eQWB) scores. Height, weight, medical history, incontinence measures, and level of physical activity also were assessed. The intraclass correlation coefficient (ICC) was computed, and differences in mean scores across HRQL measures were examined. Potential correlates of HUI3, …

Understanding The Association Of Biomedical, Psychosocial And Behavioral Risks With Adverse Pregnancy Outcomes, Michele Kiely, Ayman El-Mohandes, Marie G. Gantz, Dhuly Chowdhury, Jutta S. Thornberry, M. Nabil El-Khorazaty

Publications and Research

Objectives: This study investigates the relationship between diabetes, hypertension, preeclampsia, and Body Mass Index (BMI) -- the most common and interrelated medical conditions occurring during pregnancy; sociodemographic and behavioral risk factors; and adverse pregnancy outcomes in high-risk urban African American women in Washington, DC.

Methods: Data are from a randomized controlled trial conducted in 6 prenatal clinics. Women in their 1^st or 2^nd trimester were screened for behavioral risks (smoking, environmental tobacco smoke exposure, depression, and intimate partner violence) and demographic eligibility. 1,044 were eligible, interviewed and followed through their pregnancies. Classification and Regression Trees (CART) methodology was …

Advancers In Optical Imaging In Cancer Research — Part 2, Robert R. Alfano

Publications and Research

No abstract provided.

Sharepoint Portal - Lehman Connect Master’S Thesis Repository Library – It Strategic Partnership, Madeline Cohen, David Stevens, Rasun Williams

Publications and Research

Lehman College’s Leonard Lief Library and Information Technology Division launched the Lehman Master’s Thesis Repository on its new Sharepoint portal in September 2011. The project team consisted of two librarians and three IT engineers. The presentation will outline the project’s development including rationale, the decision to host the repository on the Sharepoint portal, access issues, migration of data, custom programming, best practices and conclusions on the benefits of Library-IT collaboration.

International Trade Continues To Excel As The Global Economy Stalls: A Review Of U.S And New York Customs District Trade Through August 2011, Eugene Spruck

Publications and Research

In this paper, Eugene Spruck, a Weissman Center Fellow who served as the Chief Economist of the Port Authority of New York and New Jersey for more than a decade, reviews U.S. and New York Customs District for the first eight months of 2011. His analysis shows that U.S. international trade continued to grow at double digit rates in 2011 even as the U.S. economy stalled and the risks to the global recovery increased dramatically. The value of U.S. two-way international trade increased 17.3 percent through August 2011, to more than $2.4 trillion. Trade through the New York region increased …

Multiple Sclerosis Is Not A Disease Of The Immune System, Angelique Corthals

Publications and Research

Multiple sclerosis is a complex neurodegenerative disease, thought to arise through autoimmunity against antigens of the central nervous system. The autoimmunity hypothesis fails to explain why genetic and environmental risk factors linked to the disease in one population tend to be unimportant in other populations. Despite great advances in documenting the cell and molecular mechanisms underlying MS pathophysiology, the autoimmunity framework has also been unable to develop a comprehensive explanation of the etiology of the disease. I propose a new framework for understanding MS as a dysfunction of the metabolism of lipids. Specifically, the homeostasis of lipid metabolism collapses during …

Review Of The Website The Nuremberg Trials Project, John A. Drobnicki

Publications and Research

Review of the website The Nuremberg trials project.

Phylogenomics Of Reichenowia Parasitica, An Alphaproteobacterial Endosymbiont Of The Freshwater Leech Placobdella Parasitica, Sebastian Kvist, Apurva Narechania, Alejandro Oceguera-Figueroa, Bella Fuks, Mark E. Siddall

Publications and Research

Although several commensal alphaproteobacteria form close relationships with plant hosts where they aid in (e.g.,) nitrogen fixation and nodulation, only a few inhabit animal hosts. Among these, Reichenowia picta, R. ornata and R. parasitica, are currently the only known mutualistic, alphaproteobacterial endosymbionts to inhabit leeches. These bacteria are harbored in the epithelial cells of the mycetomal structures of their freshwater leech hosts, Placobdella spp., and these structures have no other obvious function than housing bacterial symbionts. However, the function of the bacterial symbionts has remained unclear. Here, we focused both on exploring the genomic makeup of R. parasitica and on …

Impaired Structural Connectivity Of Socio-Emotional Circuits In Autism Spectrum Disorders: A Diffusion Tensor Imaging Study, Stephanie H. Ameis, Jin Fan, Conrad Rockel, Aristotle N. Voineskos, Nancy J. Lobaugh, Latha Soorya, A. Ting Wang, Eric Hollander, Evdokia Anagnostou

Publications and Research

Background Abnormal white matter development may disrupt integration within neural circuits, causing particular impairments in higher-order behaviours. In autism spectrum disorders (ASDs), white matter alterations may contribute to characteristic deficits in complex socio-emotional and communication domains. Here, we used diffusion tensor imaging (DTI) and tract based spatial statistics (TBSS) to evaluate white matter microstructure in ASD. Methods/Principal Findings DTI scans were acquired for 19 children and adolescents with ASD (∼8–18 years; mean 12.4±3.1) and 16 age and IQ matched controls (∼8–18 years; mean 12.3±3.6) on a 3T MRI system. DTI values for fractional anisotropy, mean diffusivity, radial diffusivity and axial …

A Novel Mutation In The Hsd17b10 Gene Of A 10-Year-Old Boy With Refractory Epilepsy, Choreoathetosis And Learning Disability, Laurie H. Seaver, Xue-Ying He, Keith Abe, Tina Cowan, Gregory M. Enns, Lawrence Sweetman, Manfred Philipp, Sansan Lee, Mazhar Malik, Song-Yu Yang

Publications and Research

Hydroxysteroid (17beta) dehydrogenase 10 (HSD10) is a mitochondrial multifunctional enzyme encoded by the HSD17B10 gene. Missense mutations in this gene result in HSD10 deficiency, whereas a silent mutation results in mental retardation, X-linked, syndromic 10 (MRXS10). Here we report a novel missense mutation found in the HSD17B10 gene, namely c.194T>C transition (rs104886492), brought about by the loss of two forked methyl groups of valine 65 in the HSD10 active site. The affected boy, who possesses mutant HSD10 (p.V65A), has a neurological syndrome with metabolic derangements, choreoathetosis, refractory epilepsy and learning disability. He has no history of acute decompensation or …

“I Could Study Anywhere, As Long As I Could Sit I’Ll Study:” Student Spaces And Pathways At The City University Of New York, Maura A. Smale, Mariana Regalado

Publications and Research

Undergraduate students at the City University of New York navigate multiply occupied places as they attend college on the urban campuses of this commuter institution. CUNY students often negotiate competing diversions from their scholarly experiences, including family obligations and job responsibilities, that constrain them both temporally and financially. Additionally, space considerations at home, school, and the commute influence and shape student activities and opportunities. In this paper we examine how college students interact with school spaces, from where they store their books to where they study and write their papers, and to what degree they succeed at constituting these areas …

Relational Memory: A Daytime Nap Facilitates The Abstraction Of General Concepts, Hiuyan Lau, Sara E. Alger, William Fishbein

Publications and Research

It is increasingly evident that sleep strengthens memory. However, it is not clear whether sleep promotes relational memory, resultant of the integration of disparate memory traces into memory networks linked by commonalities. The present study investigates the effect of a daytime nap, immediately after learning or after a delay, on a relational memory task that requires abstraction of general concept from separately learned items. Specifically, participants learned English meanings of Chinese characters with overlapping semantic components called radicals. They were later tested on new characters sharing the same radicals and on explicitly stating the general concepts represented by the radicals. …

Solution Structure And Dna-Binding Properties Of The Phosphoesterase Domain Of Dna Ligase D, Aswin Natarajan, Kaushik Dutta, Deniz B. Temel, Pravin A. Nair, Stewart Shuman, Ranajeet Ghose

Publications and Research

The phosphoesterase (PE) domain of the bacterial DNA repair enzyme LigD possesses distinctive manganese-dependent 3'-phosphomonoesterase and 3'-phosphodiesterase activities. PE exemplifies a new family of DNA end-healing enzymes found in all phylogenetic domains. Here, we determined the structure of the PE domain of Pseudomonas aeruginosa LigD (PaePE) using solution NMR methodology. PaePE has a disordered N-terminus and a well-folded core that differs in instructive ways from the crystal structure of a PaePE•Mn(2+)• sulfate complex, especially at the active site that is found to be conformationally dynamic. Chemical shift perturbations in the presence of primertemplate duplexes with 30-deoxynucleotide, …

Dearabizing Arabia: Tracing Western Scholarship On The History Of The Arabs And Arabic Language And Script, Saad D. Abulhab

Publications and Research

This book is a reference book on the history of the Arabic Language and script, which goes beyond the sole discussion of technical matters. It studies objectively the evidence presented by modern-day western archeological discoveries together with the evidence presented by the indispensable scholarly work and research of past Islamic Arab civilization era. The book scrutinizes modern western theories regarding the history of the Arabs and Arabic language and script in connection with the roles played by Western Near East scholarship, religion and colonial history in the formation of current belief system, which is an essential step to study this …

Developing A Community-Based Genetic Nomenclature For Anole Lizards, Kenro Kusumi, Rob J. Kulathinal, Arhat Abzhanov, Stéphane Boissinot, Nicholas G. Crawford, Brant C. Faircloth, Travis C. Glenn, Daniel E. Janes, Jonathan B. Losos, Douglas B. Menke, Steven Poe, Thomas J. Sanger, Christopher J. Schneider, Jessica Stapley, Juli Wade, Jeanne Wilson-Rawls

Publications and Research

Background Comparative studies of amniotes have been hindered by a dearth of reptilian molecular sequences. With the genomic assembly of the green anole, Anolis carolinensis available, non-avian reptilian genes can now be compared to mammalian, avian, and amphibian homologs. Furthermore, with more than 350 extant species in the genus Anolis, anoles are an unparalleled example of tetrapod genetic diversity and divergence. As an important ecological, genetic and now genomic reference, it is imperative to develop a standardized Anolis gene nomenclature alongside associated vocabularies and other useful metrics. Results Here we report the formation of the Anolis Gene Nomenclature Committee (AGNC) …

Potential Unique Causes Of Burnout For Chiropractic Professionals, Shawn Williams

Publications and Research

Objective The objective of this narrative review is to discuss the potential for burnout in chiropractic practitioners. This discussion is grounded in the job demands-resource model, the conservation of resources model, the unique profession-specific stressors experienced by chiropractors, and information from similar health care professions. Methods A search using both the indexed (PubMed and PsychLit) and nonindexed psychosocial literature was used. Other resources included the Cochrane Library, articles from governing bodies of the chiropractic profession, trade magazines, and research conferences and symposium proceedings. Articles were analyzed following the grounded theory principles: open coding and memos for conceptual labeling, axial coding …

Wave-Function Functionals For The Density, Marlina Slamet, Xiao-Yin Pan, Viraht Sahni

Publications and Research

We extend the idea of the constrained-search variational method for the construction of wave-function functionals psi[chi] of functions chi. The search is constrained to those functions chi such that psi[chi] reproduces the density rho(r) while simultaneously leading to an upper bound to the energy. The functionals are thereby normalized and automatically satisfy the electron-nucleus coalescence condition. The functionals psi[chi] are also constructed to satisfy the electron-electron coalescence condition. The method is applied to the ground state of the helium atom to construct functionals psi[chi] that reproduce the density as given by the Kinoshita correlated wave function. The expectation of single-particle …

Progesterone-Induced Changes In The Phosphoryl Potential During The Meiotic Divisions In Amphibian Oocytes: Role Of Na/K-Atpase, Gene A. Morrill, Terry L. Dowd, Adele B. Kostellow, Raj K. Gupta

Publications and Research

Background Progesterone triggers resumption of the first meiotic division in the Rana pipiens oocyte by binding to the N-terminal external loop of the catalytic subunit of Na/K-ATPase, releasing a cascade of lipid second messengers. This is followed by internalization of specific membrane proteins, plasma membrane depolarization and nuclear membrane breakdown, culminating in arrest at second metaphase. Results Progesterone initiates an increase in phosphoryl potential during the first meiotic division, resulting in the accumulation of high energy protein phosphate by second metaphase arrest. 31P-NMR, with saturation transfer, demonstrates that the phosphocreatine level rises ~2 fold and that the "pseudo" first order …

Migration And Invasion Of Brain Tumors, Richard A. Able, Jr., Veronica Dudu, Maribel Vazquez

Publications and Research

Recent advances in molecular biology have led to new insights in the development, growth and infiltrative behaviors of primary brain tumors (Demuth and Berens, 2004; Huse and Holland, 2010; Johnson et al., 2009; Kanu et al., 2009). These tumors are derived from various brain cell lineages and have been historically classified on the basis of morphological and, more recently, immunohistochemical features with less emphasis on their underlying molecular pathogenesis (Huse and Holland, 2010). The detailed molecular characterization of brain tumors has laid the groundwork for augmentation of standard treatment with patient-specific designed targeted therapies (Johnson et al., 2009; Kanu et …

Cervical Remodeling/Ripening At Term And Preterm Delivery: The Same Mechanism Initiated By Different Mediators And Different Effector Cells, Juan M. Gonzalez, Zhong Dong, Roberto Romero, Guillermina Girardi

Publications and Research

Background Premature cervical remodeling/ripening is believed to contribute to preterm delivery (PTD), the leading cause of perinatal morbidity and mortality. Despite considerable research, the causes of term and PTD remain unclear, and there is no effective treatment for PTD. We previously demonstrated that complement activation plays a causative role in cervical remodeling that leads to PTD in mice. Methodology/Principal Findings Here we found that complement activation is not required for the physiological process that leads to term delivery in mice. Neither increased C3 cervical deposition nor increased C3a and C5a serum levels were observed at term. In addition, macrophages infiltration …

A Different Kind Of Quarterback, Jerry Charles Guyden

Publications and Research

I am not big on celebrations, nor do I accept many invitations to receive awards. There is much work to be done, and the reward is in the doing. I learned this lesson early from my parents, Martha and Robert Guyden. However, I am humbled that anyone would even mention my name in association with E. E. Just. I, like he, was born into a segregated America, and somehow we both found biology. I think Just's life story instigates a discussion on diversity in science, as well it should. However, after reading Tyrone Hayes' (2010 E. E. Just Award recipient) …

Towards A Metatheory Of Budgeting, Dan Williams, Thad D. Calabrese

Publications and Research

In this paper. we suggest that many budget theories actually are about appropriating and not about budgeting. We trace this development back to the classic budgeting question posed by V.O. Keys in 1940. To clarify the issue, we examine early normative theories of budgeting, and apply many contemporary theories about budgeting to the budgeting process advocated for in this early work. By analyzing current theories, we show that budget theories are, in many cases, simply focused on parts of the budget process or on the role of techniques in decision making. Our analyses suggest that rather than theories competing with …

Hezekiah And Charity Mills Of Westport, Connecticut, John A. Drobnicki

Publications and Research

A profile of the author’s great-great-great-great grandparents, who were also second cousins once-removed.

Can There Be Government Accounting Without Accountability?, Michael Granof

Publications and Research

No abstract provided.