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The Dopamine D2 Receptor Gene And Depressive And Anxious Symptoms In Childhood: Associations And Evidence For Gene-Environment Correlation And Gene-Environment Interaction, Elizabeth P. Hayden, Daniel N. Klein, Lea R. Dougherty, Thomas M. Olino, Rebecca S. Laptook, Margaret W. Dyson, Sara J. Bufferd, C. Emily Durbin, Haroon I. Comardelle, Sinead Currie, Caitlin Denton, Cheryce L. Harrison, Tayla Lamerton, Gabriela P. Mena, Lisa Moran, Michelle Mottola, Taniya S. Nagpal, Lisa Vincze, Stephanie Schoeppe
The Dopamine D2 Receptor Gene And Depressive And Anxious Symptoms In Childhood: Associations And Evidence For Gene-Environment Correlation And Gene-Environment Interaction, Elizabeth P. Hayden, Daniel N. Klein, Lea R. Dougherty, Thomas M. Olino, Rebecca S. Laptook, Margaret W. Dyson, Sara J. Bufferd, C. Emily Durbin, Haroon I. Comardelle, Sinead Currie, Caitlin Denton, Cheryce L. Harrison, Tayla Lamerton, Gabriela P. Mena, Lisa Moran, Michelle Mottola, Taniya S. Nagpal, Lisa Vincze, Stephanie Schoeppe
Paediatrics Publications
ObjectiveS: Research implicates the A1 allele of the dopamine D2 receptor gene (DRD2) Taq1A polymorphism in the development of depression and anxiety. Furthermore, recent papers suggest that children with A1 allele of this gene may receive less positive parenting, and that the effects of this gene on child symptoms may be moderated by parenting. We sought to replicate and extend these findings using behavioral measures in a nonclinical sample of young children. Methods: In a sample of 473 preschool-aged children and their mothers, structured clinical interview measures and maternal reports of child symptoms were collected, and standardized observations of parent-child …
The Role Of Brain-Derived Neurotrophic Factor Genotype, Parental Depression, And Relationship Discord In Predicting Early-Emerging Negative Emotionality, Elizabeth P. Hayden, Daniel N. Klein, Lea R. Dougherty, Thomas M. Olino, Margaret W. Dyson, C. Durbin, Haroon I. Sheikh, Shiva M. Singh
The Role Of Brain-Derived Neurotrophic Factor Genotype, Parental Depression, And Relationship Discord In Predicting Early-Emerging Negative Emotionality, Elizabeth P. Hayden, Daniel N. Klein, Lea R. Dougherty, Thomas M. Olino, Margaret W. Dyson, C. Durbin, Haroon I. Sheikh, Shiva M. Singh
Paediatrics Publications
The brain-derived neurotrophic factor (BDNF) gene is a plausible candidate for early-emerging negative emotionality (NE), and evidence suggests that the effects of this gene may be especially salient in the context of familial risk for child maladjustment. We therefore examined whether the single-nucleotide polymorphism producing a valine-to-methionine substitution at codon 66 (val66met) of the BDNF gene was associated with childhood NE, in the context of parental depression and relationship discord. A sample of 413 three-year-old children was assessed for NE using standardized laboratory measures. The children's parents completed clinical interviews as well as a measure of marital satisfaction. Children with …