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S-Nitrosoglutathione Reductase-Dependent Ppargamma Denitrosylation Participates In Msc-Derived Adipogenesis And Osteogenesis, Yenong Cao
Open Access Dissertations
Osteogenesis and adipogenesis are two closely linked processes that share the same precursor, bone marrow mesenchymal stem cells (MSCs). MSCs are a rare population of non-hematopoietic stromal cells, present in bone marrow and almost every type of connective tissue. It is crucial to understand the signals that govern the specificity of MSC differentiation. Adipogenic transcription factor PPARγ can stimulate adipogenesis while inhibit osteogenesis. However, the role of potential regulators of PPARγ activity in this differentiation shift remains unknown. One potential regulator is nitric oxide (NO). NO enhances adipogenesis of human preadipocytes while decreasing cell proliferation. Studies in mice with a …
Rac1b Regulates The Neurotrophin-3 Mediated Neuronal Commitment Of Bone Marrow Derived Miami Cells, Kevin M. Curtis
Rac1b Regulates The Neurotrophin-3 Mediated Neuronal Commitment Of Bone Marrow Derived Miami Cells, Kevin M. Curtis
Open Access Dissertations
Emerging trends in cell-therapy based tissue repair have focused on the renewable source of adult stem cells including human bone marrow-derived mesenchymal stromal cells (hMSCs). Due to immunomodulatory properties as well as a potential to differentiate into cells characteristic of all three germ layers, hMSCs provide a source of immature cells for utilization in cell-therapy based treatments. Marrow isolated adult multilineage inducible (MIAMI) cells are a homogeneous sub-population of hMSCs which maintain self-renewal potential during ex vivo expansion, in addition to efficiently undergoing trans-differentiation into neuron-like cells in vitro. Even though hMSCs have the potential to be used for neural …