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Neuroprotection Against Alzheimer’S And Lifespan Extension Induced By Dietary Restriction Are Associated With Metabolomic Changes And Depend On Oxidative Resistance Protein 1 (Oxr1), George W. Brownridge Iii
Neuroprotection Against Alzheimer’S And Lifespan Extension Induced By Dietary Restriction Are Associated With Metabolomic Changes And Depend On Oxidative Resistance Protein 1 (Oxr1), George W. Brownridge Iii
Natural Sciences and Mathematics | Biological Sciences Master's Theses
Dietary restriction (DR) has been demonstrated to be a robust means of extending the healthspan and lifespan, along with improving cognitive performance in various model organisms from yeast to primates, possibly by mediating neuroprotection. We utilized the Drosophila melanogaster model organism to better understand the molecular pathways that enable DR-induced benefits. By performing a genome-wide associated screening of the Drosophila Genetic Reference Panel (DGRP) that catalogues all natural genetic variants, we discovered that Oxidative resistance protein 1 (OXR1) showed the most significant difference in expression between DR and the inverse intervention of ad libitum (AL). Our research found that OXR1 …