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Zyflamend Inhibits Adipogenesis: A Mechanistic Study Evaluating The Impact Of Phytonutrients On Adipocyte Differentiation, Victoria Frankel

Masters Theses

Zyflamend, a polyphenol herbal supplement, includes numerous different extracts. This botanical complex has been used as a natural anti-inflammatory due to its impact on COX-2. More recently, research has exhibited its potential as an anti-cancer agent. Currently, the effects of Zyflamend in non-cancer cells, specifically adipocytes, has yet to be explored. Due to Zyflamend's ability to promote activation of AMPK, it may prove relevant to study the potential interactions with cells treated with Zyflamend during differentiation, a metabolically involved process. This study sought to determine the impact of Zyflamend on non- cancer cells such as 3T3-L1 adipocytes during differentiation and …

Effects Of Wider Step Width On Knee Biomechanics In Obese And Healthy-Weight Participants During Stair Ascent, Derek Scott Yocum

Masters Theses

An increased likelihood of developing obesity-related knee osteoarthritis may be associated with increased peak internal knee abduction moment. Increases in step width may act to reduce this moment. This study focused on how step width influenced the knee joint during stair ascent by healthy and obese participants. Participants ascended stairs while walking at their preferred speed and under one of two step width conditions – preferred and increased. Obese participants experienced greater mediolateral and vertical ground reaction forces (GRFs), as well as increased peak knee extensor moments and push-off peak internal knee adduction moments. The findings of this study indicate …

Obesity In Society: The Importance Of Perception, Michael Darnell Oliver Ii

Masters Theses

In the current study, I examined the role of positive and negative media images of obese individuals on attitudes and physiological responding in relation to an actual discrimination incident. Various surveys were administered and Body Mass Index (BMI), salivary Alpha Amylase (sAA), and Galvanic Skin Response (GSR) or Skin Conductance (SC) were measured. Participants read a vignette in which an obese individual was discriminated against and further questions were administered to assess attributional blame. My primary hypothesis in this study was that there would be a decrease in stigma due to positive priming, specifically stigma directed at the obese population. …

Overweight And Obese Children's Social Interactions And Peer Responses, Meagan Johannah Green

Masters Theses

This study examined the nature of obese, overweight, and healthy weight children’s social interactions and experiences in a Head Start preschool classroom. Obese, overweight, and healthy weight children were observed during free interaction periods of the day (times when peers would serve as primary play partners). The children’s social interactions (including number of social bids, invitations, and their outcomes, social construction strategies, social roles) were observed and comparisons were made between twelve obese and overweight children and twenty six healthy weight peers. There were significant differences in the levels of overall assertiveness between the groups, with healthy weight children being …

Do Increases In Fruit Intake Lead To Substitutive Eating Patterns And Decreases In Overall Energy Intake In Normal Weight Adults?, Shireen Amanda Sobhani

Masters Theses

Background: It is suggested that increasing intake of fruits and vegetables may lead to decreased energy intake via substitution of higher energy-dense foods, such as snack foods (SF; i.e. candy, chips, cookies). This study investigated the impact of increasing fruit (F; grapes) intake, via increased portion size, on SF (potato chips) intake during a meal and whether increases in F intake affected total meal energy intake, via reducing SF intake (substitutive eating), in normal-weight adults. A secondary objective investigated whether the relative reinforcing value (RRV) of SF was a moderator of the substitutive relationship between F and SF.

Methods: Using …

Social Support In An Internet-Based Weight Loss Intervention Among College Students, Yijia Zhang

Masters Theses

Objective: To assess college students’ perceptions regarding online social support in an 8-week Internet-based weight loss intervention.

Participants: Participants were those randomized to the intervention group of an online weight loss intervention targeting overweight and obese college students.

Methods: Members of the intervention group had access to a private discussion forum and weekly live chat sessions, allowing for anonymous interactions. Following the 8-week intervention, intervention group members were invited to complete an online focus group, discussing these tools. The transcripts were directly copied from the live chat conversation history. Using thematic analysis, perceptions regarding online social support were identified, coded …

An Evaluation Of The Feasibility And Acceptability Of A Technology-Based Pilot Program To Reduce Overweight And Obesity Among College Students, Christine Sumie Sugimoto

Masters Theses

Background: One-third of US undergraduate students are overweight or obese, and weight gain may occur during the college years. Thus, there is a need for weight loss interventions for college students. Innovative technology-based programs may be a promising strategy to promote weight loss. Weight management interventions incorporating technology have been implemented in US university settings, with varying degrees of success.

Objective: The purpose of this study was to investigate the feasibility and acceptability of a pilot technology-based weight loss program to reduce overweight and obesity among college students.

Methods: The pilot study investigated the effectiveness of a …

Elementary School Teachers’ Perceptions Of The Role Of Physical Activity In Schools, Amanda Millwood Harrison

Masters Theses

The purpose of this qualitative study was to examine and describe elementary school teachers’ perceptions of physical activity among children in an urban, Title I, school in Tennessee. Twelve elementary teachers in Second and Third grade were interviewed using a semi-structured interview. The interview protocol was developed to guide participants from broader concepts regarding physical activity to more focused discussions on the use of physical activity during the school day.

Data presented examines the perceptions of teachers’ overall view of physical activity among children during school hours, the amount of physical activity children engaged in during school hours, the impact …

Kids Can Bike! A Parks And Recreation Program To Promote Youth Cycling, Jessica Lynn Chandler

Masters Theses

Physical inactivity is a major concern, and is believed to contribute to the high prevalence of childhood obesity in U.S. schoolchildren. To address this problem, the Knoxville Area Coalition on Childhood Obesity launched a ‘Kids Can BIKE!’ program in 2012. The bicycling program is seven weeks long and is designed to increase physical activity, teach safe cycling skills, and explore Knoxville parks and greenways while having fun. The program targeted children in grades 4 and 5 who were already enrolled in an afterschool or summer program. Once a week, the children were transported to a location where they could safely …

Angiotensinogen Gene Silencing Reduces Lipid Accumulation And Inflammation In Cultured 3t3-L1 Adipocytes, Wenting Xin Carroll

Masters Theses

Obesity is characterized by metabolic complications which are related to several life-threatening diseases. Dysregulated inflammatory adipokines secretion from adipose tissue is believed as the major contributor to obesity-associated local and systemic inflammation, insulin resistance, and other metabolic dysfunctions.

Numerous studies in our lab and others pointed to the role of local adipose tissue renin-angiotensin system (RAS) in the pathogenesis of obesity, inflammation and insulin resistance. We hypothesized that adipocytes-derived angiotensinogen (Agt) played a critical role in adipogenesis and/or lipogenesis as well as adipose inflammation. To test, we established 3T3-L1 preadipocytes stably transfected with Agt-shRNA or scrambled sequence (Sc-shRNA). Transfected preadipocytes …

The Association Of Genotype, And The Gene-Physical Activity Interaction Effect On Aerobic Fitness In Prepubertal, African American, Obese Children, Jennifer Irene Flynn

Masters Theses

Purpose: To determine the association of certain aerobic fitness and physical activity genotypes and the gene-physical activity interaction effect on aerobic fitness in pre-pubertal, African American, obese children. Methods: Subjects were 30 pre-pubertal, African American, obese children (9.5 ± 1.7 years) who were free of clinical disease. Height and weight were measured according to standard procedures. Body fat was assessed using dual energy x-ray absorptiometry, and DNA samples were collected using buccal swabs. Aerobic fitness was assessed using a cycle ergometer and the McMaster cycle protocol. ANOVAs were used to determine associations and interaction effects of the ACE, ADRB2, NOS3, …

A Healthy Community In Burlington Neighborhood, Maudy Indriani Budipradigdo

Masters Theses

Studies have shown that the rising rate of adverse physical, social and mental conditions are tightly related to a lack of physical activity, poor eating habits, and the lack of social interaction. Unlike health problems centuries ago which were often caused by lethal diseases, the contemporary health problems in the United States relate to peoples' lifestyles and built environments. Vehicle-oriented community design has caused limited physical activity and unhealthful eating habits that increase obesity and other related health problems. Modern built environments often unintentionally discourage social interactions and present unintended obstacles to physical activities which causes social and mental health …

Greenway Design And Planning For Healthy Communities: Case Study Of Knoxville, Yilin Shi

Masters Theses

Abstract

Greenway design and planning have become a multi-functional, multi-objective approach to address social, cultural and ecological concerns. Traditional greenway design and planning have focused more on ecological, historic and recreational values. However, the current focus of greenway planning is also shifting to community health, which includes both physical health and emotional health. This thesis focuses on physical health. This concern arises out of observations on obesity and physical inactivity as two of the most serious health problems in the United States which greatly threaten the quality of life in the country. Greenways can help address the issues of obesity …

The Effects Of Bisphenol A On Adipose Tissue Development, Metabolism, And Endocrine Function And The Role It May Play In The Development Of Obesity, Brantley Nelson Wyatt

Masters Theses

While diet and sedentary lifestyle remain important factors in the development of obesity, recent findings have shown the possible involvement of environmental obesogens, chemicals that can disrupt homeostatic energy balance and increase adiposity. Bisphenol A (BPA) is a compound used in the manufacturing of plastics as a hardening agent and is ubiquitous in the environment due to its widespread use. BPA has been shown to be an endocrine disruptor through its ability to mimic estrogen, which is now known to play important roles in adipose tissue growth and metabolism. In fact, a small but compelling number of studies have shown …

Regional Differences In Adipose Tissue Of The Sinclair Minipig, Suzanne Lauren Booker

Masters Theses

Adipose tissue is an endocrine organ, and its homeostatic mechanisms in normal weight, overweight and obese subjects must be elucidated. We sought to determine the basal adipose tissue biology of visceral (VIF) and subcutaneous (SQF) fat depots in 8 month old Sinclair minipigs, an animal that has been shown to be physiologically similar to humans.

Metabolic analysis showed a decrease in LDL, white blood cells (WBC), and lymphocyte percentages as the minipigs aged from 6 to 8 months (p <0.0001 and = 0.0046 and 0.0165 respectively). There were no significant changes in triglycerides, HDL, VLDL, and neutrophil percentages. There was a trend in insulin increase (P=0.0722).

Microarray analysis was performed to determine transcriptome differences between VIF and SQF. When VIF was compared to SQF, expression of a …