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Atherosclerosis: Pathology, Role Of Sd-Ldl, Particle Size Characterization Of Sd-Ldl With Multiangle Light Scattering, Akshay Sudhakar Ukey
Atherosclerosis: Pathology, Role Of Sd-Ldl, Particle Size Characterization Of Sd-Ldl With Multiangle Light Scattering, Akshay Sudhakar Ukey
Masters Theses
Atherosclerosis is an inflammatory disease due to the accumulation of lipids in the inner wall of arteries. As per the report of Center of Diseases Control and Prevention (CDC), 1 in every 4 deaths is due to heart diseases each year. Atherosclerosis occurs when artery walls harden by the buildup of cholesterol, forming multiple atherosclerotic plaques within the aorta (4). Out of the modern medicines available to control cholesterol, statin is amongst the foremost widely used because it is both safe and effective in lowering high risk patients (9). However, usage of high statins dosage typically leads to some mild …
Oxidized Phospholipid Regulation Of Chronic Inflammation In Endothelial Cells, Cameron Scott Brutsche
Oxidized Phospholipid Regulation Of Chronic Inflammation In Endothelial Cells, Cameron Scott Brutsche
Masters Theses
Atherosclerosis, the primary cause of Coronary Heart Disease (CHD), has become one of the top causes of death in the world. As low-density lipoprotein (LDL) particles become trapped and oxidized inside arterial walls, the primary oxidation products of 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphatidylcholine (PAPC) induce the binding of monocytes which can potentially lead to fatty plaque build ups. A fragment of one of these oxidation products, OxPAPC, has previously been studied and can act as standard for testing new phospholipids and how they affect protein expression levels. The central hypothesis of this study was that three newly studied classes of oxidized fatty …
Oxidized Phospholipids Regulation Of The Monocyte Recruitment Parthway In Human Aortic Endothelial Cells, Piao Jian Tan
Oxidized Phospholipids Regulation Of The Monocyte Recruitment Parthway In Human Aortic Endothelial Cells, Piao Jian Tan
Masters Theses
Low-density lipoprotein particles in blood plasma invade the endothelium and become oxidized, creating risk of CHD associated with atherosclerosis, the main underlying condition in coronary heart disease. Oxidation products of the phospholipid 1-palmitoyl- 2-arachidonoyl-sn-glycerol-3-phosphatidylcholine (PAPC) are bioactive components of minimally oxidized LDL that stimulate endothelial cells that line the artery, leading to monocyte binding and atherosclerosis. It is hypothesized that the regulation of the monocyte recruitment pathway by these oxidized phospholipids is mediated by the binding of OxPAPC to one or more mediating proteins. Human recombinant VEGFR2, GRP78, and EP2bind to OxPNB, a biotinylated analog of OxPAPC, demonstrated using Western …