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Astrogliosis In The Adult Zebrafish Olfactory Bulb During Repetitive Peripheral Damage, Jackson Scheib
Astrogliosis In The Adult Zebrafish Olfactory Bulb During Repetitive Peripheral Damage, Jackson Scheib
Masters Theses
Traumatic brain injuries (TBIs), particularly if repetitive, cause massive disruptions of brain homeostasis, significant loss of neurons, and may result in death. Astrocytes are a type of cell that maintain brain homeostasis and neuronal health. Astrogliosis is a continuum of morphological and functional changes of astrocytes in response to damage. This can be neuroprotective or neurotoxic depending on the severity and type of injury. Global astrocyte scarring is typical of neurotoxic astrogliosis and is the source of secondary injury after TBIs. The adult zebrafish olfactory system is known for its capacity to recover from trauma, however, astrocytes in this system …
An Adult Zebrafish Brain Atlas To Investigate Shh Mediated Cell-Cell Signaling In Neurogenic Zones, Alyssa P. Lutservitz
An Adult Zebrafish Brain Atlas To Investigate Shh Mediated Cell-Cell Signaling In Neurogenic Zones, Alyssa P. Lutservitz
Masters Theses
Adult neurogenesis occurs in proliferative zones of the brain that contain neural progenitor cell populations capable of differentiating into specific cell types. However, we remain limited in our understanding of the signals that regulate neural progenitor cell proliferation and differentiation in adults. Recently zebrafish (Danio rerio) have emerged as an excellent model for studying the molecular mechanisms behind adult neurogenesis, because sixteen proliferative zones remain active in the adult brains. Thousands of fluorescent transgenic reporter lines have been generated in zebrafish that reveal gene expression patterns of cell-cell signaling systems, some of which may regulate neurogenesis in these …
Microglia Respond To Both Permanent And Temporary Deaferentation In The Adult Zebrafish Olfactory Bulb, Amanda K. Mckenna
Microglia Respond To Both Permanent And Temporary Deaferentation In The Adult Zebrafish Olfactory Bulb, Amanda K. Mckenna
Masters Theses
The major goal of this study was to investigate a microglial response following deafferentation in the adult zebrafish, Danio rerio, olfactory bulb. Microglia were identified in the olfactory bulb using the 4c4 antibody and phagocytic-dependent labeling (DiA). Microglia responded to both methods of deafferentation namely, permanent (cautery) and temporary (Triton X- 100). On one and three days following both permanent and temporary deafferentation there was a significant increase in microglia in the treated olfactory bulb. At five and seven days after permanent and temporary deafferentation there was no longer a significant difference between the treated and untreated olfactory bulbs, …