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Regulation Of Leukotriene C4 Biosynthesis In Calcium Ionphore A23187-Challeneged August Rat Peritoneal Leukocytes, James M. Huebner
Regulation Of Leukotriene C4 Biosynthesis In Calcium Ionphore A23187-Challeneged August Rat Peritoneal Leukocytes, James M. Huebner
Masters Theses
Leukotriene (LT) C4 is a potent myotropic product of arachidonic acid 5-lipoxygenation that is thought to play a role in the pathophysiology of immediate hypersensitivity reactions and inflammation. We designed the present study to evaluate the capacity of August (AUG) rat mixed peritoneal leukocytes to generate LTC4 when challenged with different concentrations of the Ca2+ ionophore A23187 and to test the hypothesis that LTC4 biosynthesis is regulated via a protein kinase C (PKC)-dependent mechanism. The AUG rat, which has a spontaneously high number of peritoneal eosinophils that can be harvested by a simple lavage procedure, is …
Identification Of An Insulin-Responsive Element In The Rat Glucose-6-Phosphate Dehydrogenase Gene, Sheri Lynn Holmen
Identification Of An Insulin-Responsive Element In The Rat Glucose-6-Phosphate Dehydrogenase Gene, Sheri Lynn Holmen
Masters Theses
The expression of several genes has been shown to be either positively or negatively regulated by insulin at the transcriptional level, however no single insulin responsive DNA element has yet been identified. The transcription factors responsible for stimulation or inhibition of gene expression by insulin also remain to be identified. In recent years, expression of the gene for glucose-6-phosphate dehydrogenase (G6PDH) in primary rat hepatocytes has been found to be influenced by hormones such as insulin, dexamethosone, and glucagon. The molecular mechanism(s) however, underlying hormonal regulation of G6PDH gene transcription remains to be elucidated. The focus of this study was …
Differential Distribution Of D4 And D2 Dopamine Receptors In Rat Brain: An Autoradiographic Study Using [3H]Ym-09151-2 And [3H]Raclopride, Nancy C. Stratman
Differential Distribution Of D4 And D2 Dopamine Receptors In Rat Brain: An Autoradiographic Study Using [3H]Ym-09151-2 And [3H]Raclopride, Nancy C. Stratman
Masters Theses
Extrapyramidal side effects (EPS) are associated with most antipsychotics for the treatment of schizophrenia since these agents antagonize dopamine D2 receptors in the nigrostriatal pathway, a brain system that regulates motor functions. Clozapine, an atypical antipsychotic agent in that it does not produce EPS, was found to be more selective for the D4 than the D2 receptor. The purpose of this study was to locate the D4 receptor in rat brain by autoradiographic comparison studies with [3H]YM-09151-2, a D2 , D3, and D4 radioligand, to [3H]raclopride, a D …
Characterization And Expression Of Pseudomonas Fluorescens L-Arabinose Dehydrogenase: Genetic Elements In Pseudomonas Putida, Carol M. Wierenga
Characterization And Expression Of Pseudomonas Fluorescens L-Arabinose Dehydrogenase: Genetic Elements In Pseudomonas Putida, Carol M. Wierenga
Masters Theses
An assay based on the spectrophotometeric properties of NAD/NADH was developed to detect the degradation of L-arabinose to L-arabinolactone. This assay was used to determine the expression of the L-arabinose utilization genes contained in Pseudomonas fluorescens and in the plasmid, designated pPZ221, contained in Pseudomonas putida. The results from this assay, in conjunction with various growth kinetics, indicate that pPZ221 is inducible and repressible for L-arabinose utilization. Thus, the P. fluorescens chromosomal insert in pPZ221 for L-arabinose utilization does appear to contain the regulatory genes necessary for controlling the expression of an L-arabinose operon.
Normal Kinetic Patterns Of The Lower Extremities During Natural Walking In Children Aged Six To Ten, Thomas Ellexson, Christopher Nawrocki, Darrin Schober
Normal Kinetic Patterns Of The Lower Extremities During Natural Walking In Children Aged Six To Ten, Thomas Ellexson, Christopher Nawrocki, Darrin Schober
Masters Theses
The purpose of this research was to initiate a normative pediatric three-dimensional lower extremity kinetic database specific to the Mary Free Bed Hospital/Grand Valley State University Center for Human Kinetic Studies. Twenty healthy children (eleven girls and nine boys) with a mean age of 7.9 years volunteered for this study. Lower extremity kinetic data were obtained using a computerized three-dimensional motion analysis system coupled with a force plate. Kinematic and kinetic data were pooled and mean/standard deviations at each one percent of the gait cycle were determined for the twenty normative children. Results of the pediatric kinetic data were similar …
The Relationship Among Isokinetic Knee Parameters And Three Functional Tests, Kristen Brinks, Ronda Delong, Tanya Stout
The Relationship Among Isokinetic Knee Parameters And Three Functional Tests, Kristen Brinks, Ronda Delong, Tanya Stout
Masters Theses
The purpose of this study was to investigate the correlation between knee strength and endurance, as tested by the Biodex{dollar}\sp\circler{dollar} isokinetic system, and the lateral step-up, cross-over hop for distance, and triple hop for distance. Subjects included 20 males and 30 females aged 21-40 years with no history of low back, hip, knee, or ankle injury that was treated by a physician. Bilateral knee flexion and extension strength, power, and endurance was measured at 60, 180 and 300 degrees/second with the hip extended and flexed 115{dollar}\sp\circ{dollar}. Isokinetic data were normalized to body weight and correlated to hop distance which was …
The Effect Of Family Participation On The Outcome Of Patients With Traumatic Brain Injury In Rehabilitation, Grant Middleton, Brett Ransom
The Effect Of Family Participation On The Outcome Of Patients With Traumatic Brain Injury In Rehabilitation, Grant Middleton, Brett Ransom
Masters Theses
The purpose of this study was to explore the relationship between physical therapists' perceptions and institutional policies relating to family participation in rehabilitation and rehabilitation outcome of patients with traumatic brain injury. Utilizing surveys, we collected information about institutional policy from institutions that were members of the Commission for Accreditation of Rehabilitation Facilities (CARF) in the Midwestern United States. Thirteen institutional surveys provided usable Functional Independence Measure (FIM) scores for patients rehabilitated in 1993, which were used as the outcome measure. The therapists' perceptions survey (n = 104) gathered data about the belief of physical therapists relating to family involvement …
The Effects Of Partial Unweighting On Hemiplegic Gait, Natasha A. Creaser, Michael W. Jones
The Effects Of Partial Unweighting On Hemiplegic Gait, Natasha A. Creaser, Michael W. Jones
Masters Theses
This study investigated the effects of 30% body weight support on gait in two individuals with hemiplegia secondary to stroke. Two subjects with right hemiplegia were tested. Each completed four trials, two full weight bearing and two unweighted 30%, in random order. Each trial consisted of walking six meters on a treadmill at the subjects' self-selected speed. Temporal distance data were collected via Stride Analyzer footswitches. Subjects were also videotaped from the side during all trials. We expected velocity, cadence, stride length, uninvolved limb swing time, and involved limb stance time to increase with unweighting. Subjects 1's results agreed only …