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The Deformability Of Red Blood Cells In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Me/Cfs), Brendan Robert Schmidt
The Deformability Of Red Blood Cells In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Me/Cfs), Brendan Robert Schmidt
Master's Theses
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease that causes profound fatigue in its sufferers as well as loss of concentration, headaches, and sleep abnormalities. Unfortunately, the disease is poorly diagnosed, and etiology is not known. Although the ME/CFS patients do not show anemic readings, and their arterial partial pressure is normal, it is possible that their extreme post-exertional malaise stems from poor microvascular perfusion and oxygenation. Previous studies have indicated that the red blood cells (RBCs) in ME/CFS patients show evidence of oxidative damage. We hypothesized that the RBC deformability metrics can serve as a reliable biomarker of ME/CFS …
Non-Invasive Hyperglycemia Detection Using Ecg And Deep Learning, Renato Silveira Cordeiro
Non-Invasive Hyperglycemia Detection Using Ecg And Deep Learning, Renato Silveira Cordeiro
Master's Theses
Hyperglycemia is characterized by an elevated level of glucose in the blood. It is normally asymptomatic, except for an extremely high level, and thus a person can live in that state for years before the negative - sometimes irreversible - health impacts appear. Unexpected hyperglycemia can also be an indication of diabetes, a chronic disease that, when not treated, can lead to serious consequences, including limb amputations and even death. Therefore, identifying hyperglycemic state is important. The most common and direct way to measure a person’s glucose level is by directly assessing it from a blood sample by pricking a …
Development Of A Computational Elbow Joint Model To Analyze The Effects Of Synovial Fluid On Articular Cartilage During Joint Motion, Abhishek Yellapragada
Development Of A Computational Elbow Joint Model To Analyze The Effects Of Synovial Fluid On Articular Cartilage During Joint Motion, Abhishek Yellapragada
Master's Theses
While significant advances have been made in the development of computational elbow joint models, fluid-structure interaction (FSI) in the elbow joint has not yet been explored. The objective of this study is to develop a computational elbow joint model to simulate the effects of synovial fluid on articular cartilage during flexion, extension, pronation, and supination. The model was developed with anatomically accurate 3D bone geometries; articular cartilage geometries that were derived from the 3D bone geometries; ligaments defined as linear springs; muscles embedded as joint non-linear stiffness; and a fluid domain that encompassed the joint articulations with a homogenous, incompressible, …
Time-Invariant Tensile Necking Of Blood On An Electrowetting Digital Microfluidic Platform, Curtis Young
Time-Invariant Tensile Necking Of Blood On An Electrowetting Digital Microfluidic Platform, Curtis Young
Master's Theses
Recent developments in electrowetting-on-dielectric (EWOD) technology have expanded the possibilities for testing methods and investigation of blood. This work evaluated the development of necking geometry of whole blood and red blood cell (RBC) suspensions on a digital microfluidic (DMF) platform. This was achieved by applying tension to liquid droplet specimens on an EWOD-based device using applied electrowetting forces, thereby inducing necking. The deformation of 5 μL fluid specimens was recorded using neck radius and minimum neck width as two characteristic geometric parameters. Tensile tests were performed on phosphate-buffered saline (PBS), whole blood diluted in PBS, and RBCs suspended in PBS …
Formation Of Clot Analogs Between Co-Flow Fluid Streams In A Microchannel Device, Sue-Mae Saw
Formation Of Clot Analogs Between Co-Flow Fluid Streams In A Microchannel Device, Sue-Mae Saw
Master's Theses
Hemodynamics plays an important role in the formation of blood clots, for which changes in hydrodynamic stresses and transport phenomena can initiate or inhibit the clotting process. The fibrin network is highly influential in the structural mechanics of a clot. This work demonstrated an ability to produce clot analogs at the boundary between co-flow fluid streams, and investigated the dependence of clot shape and density distribution on flow conditions. The time evolution of fibrin clots formed in microchannel flow was investigated using fluorescence imaging. Clots were formed in a polydimethylsiloxane (PDMS) microfluidic device which consisted of a Y-shaped microchannel with …