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An Assessment Of Inp/Zns As Potential Anti-Cancer Therapy: Quantum Dot Treatment Induces Stress On Hela Cells, Victoria Grace Davenport
An Assessment Of Inp/Zns As Potential Anti-Cancer Therapy: Quantum Dot Treatment Induces Stress On Hela Cells, Victoria Grace Davenport
MSU Graduate Theses
Indium Phosphide/Zinc Sulfide (InP/ZnS) quantum dots (QDs) are an emerging option in QD technologies for uses of fluorescent imaging as well as targeted drug and anti-cancer therapies based on their customizable properties. In this study we explored effects of InP/ZnS when treated with HeLa cervical cancer cells. We employed XTT viability assays, reactive oxygen species (ROS) analysis, and apoptosis analysis to better understand cytotoxicity extents at different concentrations of InP/ZnS. In addition, we compared the transcriptome profile from the QDtreated HeLa cells with that of untreated HeLa cells to identify changes to the transcriptome in response to the QD. Intracellular …
Identifying And Comparing Transcriptome Alterations In Saccharomyces Cerevisiae Exposed To A Variety Of Quantum Dots, Cullen Horstmann
Identifying And Comparing Transcriptome Alterations In Saccharomyces Cerevisiae Exposed To A Variety Of Quantum Dots, Cullen Horstmann
MSU Graduate Theses
The primary focus of my research was to obtain global gene expression profiles of baker’s yeast exposed to sub-lethal doses of nanoparticles, such as silver nanoparticles (AgNPs), yellow- emitting CdSe/ZnS quantum dots (QDs), green-emitting CdSe/ZnS QDs, and InP/ZnS QDs, to reveal novel insights on their unique mechanisms of toxicity. Despite their diverse applications, their long-lasting effects on the environment and human health are not well understood. To assess their toxicity, I administered experiments that exposed Saccharomyces cerevisiae to a variety of nanoparticles and measured cell viability, ROS levels, and changes in gene expression. Most notably, I used RNA-sequencing (RNA-seq) to …