Productivity Working From Home During The Pandemic, Jacqueline M. Veglia

Honors Theses and Capstones

I will be focusing my research on productivity during working from home. Specifically I will be focusing on men versus women productivity levels working from home, as well as single women versus women with children. This research is also designed to investigate the extent of work employees do while working at home and their productivity levels. The Covid19 pandemic had a major impact on the working environment. People were stuck inside their houses and were not able to go to their offices for months to years and this is still an ongoing problem we are dealing with today. It can …

The Impact Of Nutrient Depletion On The Effect Of Hhq On Emiliania Huxleyi, Marley Gonsalves

Honors Theses and Capstones

Emiliania huxleyi is a ecologically important, bloom-forming coccolithophore. HHQ is a bacteria compound that causes cell stasis in E. huxleyi that can lead to bloom termination. This study analyzed the role that nutrient depletion plays in this relationship. Results show that nitrogen depletion protects cells from the effects of HHQ, affecting bloom dynamics.

Investigating The Role Of Bromodomain Proteins On Histone Post-Translational Modifications In Toxoplasma Gondii, Joshua Steven Berthiaume

Honors Theses and Capstones

Toxoplasma gondii is a prevalent pathogenic parasite that infects approximately 25 percent of the US population. For the parasite to successfully establish and maintain infection in its host, properly controlled regulation of gene expression is critical. One way Toxoplasma regulates gene expression is through modification of histone proteins that bind to DNA and can control gene accessibility. Acetylation is a modification that is added to histones that changes chromatin structure to enhance gene activation. Histone acetylation can also regulate gene expression by recruitment of important regulators such as bromodomain proteins (BDP). A previous study showed that loss of the bromodomain …

Identification Of Novel Biosynthetic Gene Clusters Encoding For Polyketide/Nrps-Producing Chemotherapeutic Compounds From Marine-Derived Streptomyces Hygroscopicus From A Marine Sanctuary, Hannah Ruth Flaherty

Honors Theses and Capstones

Nearly one out of six deaths in 2020, around ten million people, were caused by cancer, making it a leading cause of death worldwide (WHO, 2022). This major public health issue, in addition to the rise of multidrug-resistant (MDR) pathogens, provides a high demand for the discovery of new pharmaceutical drugs to be used clinically to treat these conditions. The Streptomyces genus accounts to produce 39% of all microbial metabolites currently approved for human health, indicating its potential as an important species to study for antimicrobial and anticancer agents. The long linear genome of Streptomyces contains specialized sequences known as …

Predictors Of Summer Chloride Concentrations In Urban Aquatic Ecosystems, Georgianna S. Fischer

Honors Theses and Capstones

Urban aquatic ecosystems are highly threatened by excess concentrations of chloride (Cl^-), which can negatively impact the biodiversity and functioning of aquatic ecosystems. High Cl^- concentrations in most northern cities come primarily from road salt use for de-icing, in the form of NaCl. Specific pathways of runoff and hydrology of waterbodies will regulate Cl^-concentrations in the months after the snowmelt season. This study attempted to understand the hydrologic controls on Cl^- concentrations and identify how the hydrology of urban ecosystems may impact exposure to chloride in streams. To accomplish this, stream sites around the …

Revolutionary Advances In The Treatment Of Genetic Disease, Emma Kaitlyn Carrigan

Honors Theses and Capstones

No abstract provided.

Meta-Analytic Connectivity Modelling Of Healthy Swallowing, Chris R. Tilton

Honors Theses and Capstones

A quantitative, voxel-wise meta-analysis was performed to investigate the brain regions involved in healthy human swallowing. Studies included in the meta-analysis (1) examined water swallowing, saliva swallowing, or both, (2) included healthy, normal subjects, and (3) reported stereotaxic brain activation coordinates in standard space. Following these criteria, a systematic literature review identified 8 studies that met the criteria. An activation likelihood estimation (ALE) meta-analysis and meta-analytic connectivity modelling (MACM) analysis were performed with BrainMap software. Ten clusters with high activation likelihood were found in the bilateral precentral gyri, right insula, left declive, right medial frontal gyrus, right dorsal nucleus of …

Cutaneous Microbiome Of Red Fox (Vulpes Vulpes) Infected With Sarcoptic Mange (Sarcoptes Scabiei), Jacqueline C. Robidoux

Honors Theses and Capstones

Sarcoptic mange is a parasitic skin disease that affects countless mammals worldwide, including red foxes (Vulpes vulpes). The symptoms, such as hair loss, crusting, and the number of mites, vary between individual foxes. Sarcoptic mange damages the skin barrier, which in turn disrupts the biodiversity of bacteria in the microbiome. It is unknown what the biodiversity of bacteria is at each stage of the disease. This experiment will compare the microbiomes of different samples with and without mange; in hopes to reveal a connection between the different severities of sarcoptic mange and the biodiversity of bacteria and fungi …

Eeg-Based Spanish Language Proficiency Classification: An Eeg Power Spectrum And Cross-Spectrum Analysis, Blaise Xavier O'Mara, Skyler Baumer

Honors Theses and Capstones

Second language proficiency may be predicted with electrophysiological techniques. In a machine learning application, this electrophysiological data may be used for language instructors and language students to assess their language learning. This study identifies how electroencephalogram (EEG) power spectrum and cross spectrum data of the brain cortex relates to Spanish second language (L2) proficiency of 20 Spanish language students of varying proficiency levels at the University of New Hampshire. The two metrics for assessing cortical power and processing were event-related desynchronization (ERD)—a measure of relative change in power—of the alpha (8-12 Hz) brain frequency band, and alpha and beta (13-30Hz) …

An Exploration Of Self-Identity In Transracial Adoptees From China, Aliya Dejun Sarris

Honors Theses and Capstones

Sparked by the COVID-19 pandemic, the author began to notice that the newest wave of Asian-American Pacific Islander (AAPI) activism was not inclusive of transracial adoptees, or people adopted by parent(s) of a different race. This study explores the unique identity of transracial adoptees specifically from China. The author explores the topics of identity, family, friends, community and overall belonging through the lens of primary and secondary sources. The primary sources include seven, hour-long interviews that the author conducted herself. Overall, the study concludes that transracial adoptees have a qualitatively different experiences than non-adopted peers that – although an incredibly …

Mpacts Of Parental Incarceration On Child's Well-Being And Interventions To Support Them, Anna Stacey Roberge

Honors Theses and Capstones

This study reviews the effectiveness and impact of current interventions for children who have incarcerated parents in New Hampshire. The negative impacts of parental incarceration have led to the need for these intervention strategies. Recently psychologists and behavioral experts have conducted their studies which show that children who have incarcerated parents are more likely to display delinquent behaviors. Additionally, studies have shown that parental incarceration can lead to the experiencing of several more psychological difficulties, such as depression, anxiety, and learning disorders (Kremer et al., 2020). Several communities have worked to implement interventions that will help these children avoid falling …

Developing Honey Bee Diagnostics At The New Hampshire Veterinary Diagnostics Lab: Successes And Challenges, Mary Feranda

Honors Theses and Capstones

No abstract provided.

Individual Behavioral And Neurobiological Markers Associated With A Vulnerable To Ethanol Use Phenotype, Kelsey M. Alimandi

Honors Theses and Capstones

Alcohol use disorder (AUD) is a chronic relapsing brain condition that is characterized by excessive alcohol consumption, continued use when faced with negative consequences, and a negative emotional state associated with withdrawals (anxiety, irritability, depression). The main challenge to treating AUD is preventing relapse. The purpose of this study was to use a prolonged-exposure model to allow rats to self-administer ethanol to determine the brain regions active during relapse events. The rats performed multiple behavioral tests such as economic demand, negative consequences, and an elevated plus maze. These tests determined how hard rats were willing to work for an ethanol …

Bioinspired Redox Active Pyrogallol For Aqueous Ion Separations, Matt Libby

Honors Theses and Capstones

No abstract provided.

A Literature Analysis Of Microgrid Optimization Studies, Izzy Medeiros

Honors Theses and Capstones

Senior civil engineering student, Izzy Medeiros, is presenting her honors thesis in the form of a literature analysis. Her research involved investigating existing microgrid studies and where there are current gaps in the knowledge. About 40 publications written within the last 20 years were analyzed for their research goals, optimization objectives, and microgrid design, pointing to where this research is currently lacking. Most real studies were conducted in Asia, as Southeast Asia has island communities that need the reliability of a renewable microgrid during extreme weather events. Photovoltaic panels in combination with wind turbines comprise the most common configuration of …

Impact Of Accent On Receptive Language Assessments For Bilingual Children, Katherine Stariknok

Honors Theses and Capstones

Language assessments are used to screen and diagnose children with language disorders. Many speech-language pathologists (SLP) practicing in Spanish in the United States do not speak Spanish as their first language, so they are administering these assessments in accented speech. This study aims to find what effect an SLP’s accent will have on a bilingual child’s language assessment. Initial findings show that participants were largely able to understand words in the L2 accent, with most of the errors due to several repeating consonantal features (i.e., voicing alone; place and manner of articulation). The broader impact of this work is to …

Targeting Stat3 In Triple Negative Breast Cancer Using Gsk3Ꞵ And Integrin Inhibitors, Emily A. Pratt

Honors Theses and Capstones

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and is known for its chemoresistance and high rate of recurrence. TNBC lacks the hormone receptors that are found in other types of breast cancer, and therefore cannot be treated with hormonal therapies. Although the initial response to chemotherapy is favorable, many TNBC patients experience a recurrence of this cancer at a secondary location and this recurrence is often more lethal than the original tumor. The Signal Transducer and Activator of Transcription (STAT) pathway is a major contributor to cancer growth and metastasis, and STAT3 is constitutively …

The Historic Returns Of Gold: Is It The Best Hedge Against Inflation?, Jack William Gillis

Honors Theses and Capstones

The world of investing is rapidly changing as technologies advance. In the past few years especially, we have seen many investors shifting toward decentralized digital money, or what is known as cryptocurrencies. Even with these new asset classes coming out, there has always been one commodity that has stuck around. Gold has been used as a store of value for millenniums. Investors tend to rely on gold because it’s believed to be a safe-haven asset, in times of economic uncertainty. This paper aims to determine whether or not this traditional mindset is still effective in today’s ever-changing investment environment. To …

Drug Research In Inhibiting Bcl6 In Ovarian Cancer, Quinn E. Beek, Sarah Walker

Honors Theses and Capstones

Ovarian cancer has a survival rate of 50 percent just five years after being diagnosed (Nguyen et al. 2020). Finding new ways to treat ovarian cancer is important to increase the survival of patients who have been diagnosed. BCL6 is a transcription factor that is involved with metastasis and promoting chemotherapy resistant cancer cells. Finding a way to inhibit BCL6 could help prevent the things listed above and lead to a new treatment for patients with ovarian cancer. Researching genes that BCL6 regulates may offer new insights into treatments that can be researched to see if they are effective in …

Implementing Universal Suicidality Screening In A Critical-Access Emergency Department, Delaney M. Kjendal, Kerry Nolte, Sara Robinson, Kimberly Force

Honors Theses and Capstones

Background: Implementation of a universal suicidality screening is considered best practice as it is associated with improved the detection of occult, or latent, suicide risk and can reduce subsequent risk. This quality improvement (QI) project evaluates the implementation of the Columbia-Suicide Severity Rating Scale (C-SSRS) to screen patients over the age of twelve at a regional healthcare system.

Methods: The QI project was conducted at Littleton Regional Healthcare (LRH) emergency department, a critical-access hospital in Littleton, New Hampshire that serves about 206 patients per week. Implementation of suicidality screening was of interest to LRH to promote mental health in the …

Cybersecurity Breaches And Auditor Turnover, Kilian O'Connell

Honors Theses and Capstones

No abstract provided.

Green Home Technology In Residential Real Estate, Edwrad King

Honors Theses and Capstones

This thesis paper explores green home technology in residential homes. The purpose of this research is to understand what green home technologies are, the extent to which they are being adopted, the factors that lead people to adoption, barriers to adoption, and if green home technology adds value to residential homes. The data methodology involves a literature review, and interviews with people who have adopted these technologies, people who have not adopted these technologies, and companies that sell these technologies. The results reveal that green home technology is something that is becoming more commonly adopted, due to factors like cost …

Nursing Students' And Recent Graduates' Observations Of Fatphobia In The Clinical Setting, Myah Kerbyson

Honors Theses and Capstones

Objectives: To investigate the incidence of fatphobic behaviors among the healthcare team and how nursing students’ and recent graduates’ observations of fatphobic behaviors impact the provision of affirming care.

Background: Weight stigma among healthcare providers can lead to fatphobia (e.g., hurtful or stigmatizing language, dismissal of symptoms). These experiences can negatively impact patients’ health and experiences with healthcare, leading some patients to avoid or delay seeking healthcare services. Fatphobia can also cause increased stress levels among patients, which places them at a higher risk of several diseases. The short-term and long-term effects of fatphobia lead overall worse health outcomes.

Methods: …

Closing Critical Gaps To Enable A Circular Plastics Economy, Melissa Rooney

Honors Theses and Capstones

No abstract provided.

Applications Of Video Game Music Theory For The Highschool/College Theory Curriculum, Daniel L. Thompson

Honors Theses and Capstones

This paper covers the origins of video game audio and the technical limitations that effected what composers could write. Several audio excerpts have been transcribed with roman numeral analysis. The goal of this project was to determine if musical excerpts from video games could supplement an existing highschool/college theory curriculum. Theory techniques ranging from simple cadences to secondary function chords are present throughout the pieces. The pieces are from a variety of games and composers from 1983 - 2014. Overall, many of the compositions contain excellent examples of theory techniques. These excerpts would best be utilized alongside existing theory material. …

The Clinical Observations Of Nursing Students And Recent Graduates Caring For Lgbtq+ People, Emily E. Roy

Honors Theses and Capstones

Objective: The next generation of nurses have increased educational preparation to provide affirming care to lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people, but an evaluation of the effectiveness of this teaching has not been performed. The purpose of this study was to identify nursing student and recent nursing graduate observations of affirming and non-affirming care of LGBTQ+ people in healthcare settings during clinical experiences. We also sought to understand how those experiences affect their ability and willingness to provide affirming health care to LGBTQ+ people.

Methods: Participants filled out a mixed methods Qualtrics survey that was distributed through school …

Neuronal Primary Cilia In Postnatal Brains & Alzheimer’S Disease Mice Eeg Patterns Under Fear Conditioning, Sierra Rose Mae Walsh

Honors Theses and Capstones

Alzheimer’s Disease (AD) is a neurodegenerative condition caused by the abnormal accumulation of amyloid β plaque. While small amounts of amyloid β plaque is to be expected with increased age, AD presents amyloid precursor protein (APP), a gene promoting inappropriate plaque formation, causing early neuronal death and tissue depreciation. APP23 transgenic mouse models contain the human mutation in the neocortical and hippocampal positions, areas revealing of plaque accumulation and memory loss. Within the hippocampal cortices, the primary cilia, which regulate higher cognition and neurodevelopment can be studied along with burst suppressions, or moments of high focal activity, to target potential …

Preliminary Findings For Stem Undergraduate Research Mentoring Across Neurodiversity, Sarah K. Young

Honors Theses and Capstones

No abstract provided.

Determining Deuterium Polarization Via Nuclear Magnetic Resonance, Nicholas Muche

Honors Theses and Capstones

Dynamic Nuclear Polarization (DNP) is a method by which the spins of electrons are specifically targeted by microwaves at resonance frequency in order to induce spin flips. Occasionally, the electron spins couple with nuclear spins and nuclear spin flips are induced. The relaxation time of the electron is significantly lower than that of the nuclei, which allows for large polarization. The main goal of the Slifer Lab is to utilize specifically prepared crystalline structures in order to separate the convoluted energy transitions ("Batman Peak") in the deuterium's nuclear magnetic resonance (NMR) signal, which would allow for tensor enhancement of deuterium. …

Reducing The Variability And Cost Of Determining The Coefficient Of Friction Of Various Lubricants, James M. Wirth

Honors Theses and Capstones

The Navy requires accurate fastener preloading for many of its fastened applications to protect the safety of the vessel and its personnel, and to ensure proper operation of various components. The preload is based on many properties including fastener materials, fastener geometries, and the coefficient of friction (COF) between mating surfaces. The COF is a critical value in determining the torque-load relationship of a fastener, and is dependent on the contact surface area and the materials in contact, the condition and finish of the contact surfaces, and any lubricant applied in these contact areas. Due to the large amount of …