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The Influence Of Prenatal Stress On Behaviors Associated With Schizophrenia And Autism Spectrum Disorder., Harold Bauerle
The Influence Of Prenatal Stress On Behaviors Associated With Schizophrenia And Autism Spectrum Disorder., Harold Bauerle
Graduate College Dissertations and Theses
Disorders such as schizophrenia (SCZ) and austism spectrum disorder (ASD) have long been associated with prenatal stress. In these three experiments, we attempted to correlate stress during gestation with behaviors considered to have good facial validity with SCZ and ASD in both juvenile and adult animals. To differentiate the effects of prenatal stress (PS) from the effects of early life stress due to a dam's behavior (MS), half of offspring animals were cross fostered to dams treated in the alternative condition as the offspring during pregnancy in experiments 2 and 3. In experiment 1, but not in 2 or 3, …
Factors In The Regulation Of Cycles Of Binge Eating Behavior, Andrew Knapp
Factors In The Regulation Of Cycles Of Binge Eating Behavior, Andrew Knapp
Graduate College Dissertations and Theses
The reasons why people may periodically resort to binge eating behavior have long been a focus of study, and the reasons are elusive and varied. For people troubled by poor sleep and living with chronic stress, binge eating may be an attempt by the brain's glucose-depleted executive processing center to both regulate (i.e., increase) glucose levels and induce restorative sleep. Recovery resulting from restorative sleep may lead to a reduction in perceived stress, improved mood, and increased willpower, reducing the likelihood of another binge episode in close temporal proximity to the sleep-induced recovery. A repetitive cycle may ensue when stress …
Glycogen Synthase Kinase-3Β: An Investigation Of The Novel Serine 389 Phosphorylation Site, Brendan Deegan Hare
Glycogen Synthase Kinase-3Β: An Investigation Of The Novel Serine 389 Phosphorylation Site, Brendan Deegan Hare
Graduate College Dissertations and Theses
Stress associated psychiatric disorders such as depression, anxiety, and post-traumatic stress disorder affect a large proportion of the population. Reductions in the complexity of neuronal morphology and reduced neurogenesis are commonly observed outcomes following stress exposure in rodent models and may represent a mechanism for the reduced brain volume in stress sensitive regions such as the hippocampus observed in individuals diagnosed with stress associated disorders. Multiple lines of evidence suggest that glycogen synthase kinase (GSK)-B may play a role in the neurodegenerative phenotype observed following stress exposure. GSK3B is atypical in that it is inhibited by phosphorylation. This inhibitory phosphorylation …
Gene Expression Noise In Stress Response As A Survival Strategy In Fluctuating Environments, Javier Garcia-Bernardo
Gene Expression Noise In Stress Response As A Survival Strategy In Fluctuating Environments, Javier Garcia-Bernardo
Graduate College Dissertations and Theses
Populations of cells live in uncertain environments, where they encounter large variations in nutrients, oxygen and toxic compounds. In the fluctuating environment, cells can sense their surroundings and express proteins to protect themselves against harmful substances. However, if the stressor appears infrequently or abruptly, sensing can be too costly or too slow, and cells cannot rely solely on it. To hedge against the sudden appearance of a stressor, cell populations can also rely on phenotypic diversification through bet-hedging. In bet-hedging, cells exploit noise in gene expression or use multistable genetic networks to produce an heterogeneous distribution of resistance-conferring protein levels. …