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Relationship Of Neuropeptide Ff Receptors With Pubertal Maturation Of Gilts, Jennifer F. Thorson, Neely L. Heidorn, Vitaly Ryu, Krzysztof Czaja, Danny J. Nonneman, C. Richard Barb, Gary J. Hausman, Gary A. Rohrer, Ligia D. Prezotto, Richard B. Mccosh, Elane C. Wright, Brett R. White, Bradley A. Freking, William T. Oliver, Stanley M. Hileman, Clay A. Lents
Relationship Of Neuropeptide Ff Receptors With Pubertal Maturation Of Gilts, Jennifer F. Thorson, Neely L. Heidorn, Vitaly Ryu, Krzysztof Czaja, Danny J. Nonneman, C. Richard Barb, Gary J. Hausman, Gary A. Rohrer, Ligia D. Prezotto, Richard B. Mccosh, Elane C. Wright, Brett R. White, Bradley A. Freking, William T. Oliver, Stanley M. Hileman, Clay A. Lents
Faculty Publications
Mechanisms governing the timing of puberty in pigs are poorly understood. A genome-wide association study for age at first estrus in pigs identified candidate genes including neuropeptide FF receptor 2 (NPFFR2), which is a putative receptor for RFamide-related peptides (RFRP). RFRP has been shown to negatively regulate secretion of reproductive hormones from hypothalamic and pituitary tissue of pigs in culture. Here, the porcine NPFFR2 gene was further screened and four potentially functional variants were identified to be associated with age at first estrus in pigs (1,288 gilts). The RFRP neurons in the porcine hypothalamus were localized in the paraventricular and …
Developmental Markers Of Genetic Liability To Autism In Parents: A Longitudinal, Multigenerational Study, Molly Losh, Gary E. Martin, Michelle Lee, Jessica Klusek, John Sideris, Sheila Barron, Thomas Wassink
Developmental Markers Of Genetic Liability To Autism In Parents: A Longitudinal, Multigenerational Study, Molly Losh, Gary E. Martin, Michelle Lee, Jessica Klusek, John Sideris, Sheila Barron, Thomas Wassink
Faculty Publications
Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents' childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents' childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development …