Digital Commons Network^™

Influences Of Porphyromonas Gingivalis On The Viability Of Esophageal Cancer Cells., Muddasir Mohammed

Electronic Theses and Dissertations

A recent study demonstrated an association between the Porphyromonas gingivalis (Pg)infection and the progression of ESCC (Gao et al., 2016). However, how Pg infection affects the nature of ESCC remains unknown. We examined the effects of Pg on the proliferation and chemotherapy drug-induced apoptosis of ESCC cells and elucidated the signaling molecules involved in these processes. Method: Apoptosis and cell proliferation were tested using Flow cytometry and Tetrazolium salt based proliferation assays respectively. Western Blot was utilized to detect the protein expression. CDK2 and Cyclin E were knocked down in the ESCC cells through transfection. Unpaired T-test and …

Synthesis And Characterization Of Targeted Bar Encapsulated Polylactic-Co-Glycolic Acid Nanoparticles To Inhibit Porphyromonas Gingivalis Biofilm Formation., Ranjith Radha Krishnan

Electronic Theses and Dissertations

Periodontal disease is one of the most prevalent infectious diseases worldwide. Between 30-50% of the global adult population suffers from periodontal disease. Some form of periodontitis is present in 46% of American adults, corresponding to annual expenditures in excess of 14 billion dollars for treatment and prevention. Current treatments for periodontal diseases involve mechanical removal of plaque, correction of risk factors, gingival surgery and/or antibiotic therapy. To our knowledge there is no effective therapeutic approach that aims to limit pathogen colonization of the oral biofilm or re-colonization after treatment. Interaction of the pathogen Porphyromonas gingivalis with oral streptococci is critical …

Determining Season Of Occupation At Tranquility Farm, Maine Using Oxygen Isotopes From Mya Arenaria, Kate Pontbriand

Electronic Theses and Dissertations

Coastal shell midden archaeological sites uniquely preserve information regarding past human habitation there as well as the about the paleoenvironment. In this study, oxygen isotopes (δ18O) from archaeological Mya arenaria shells collected from the Tranquility Farm site in Gouldsboro, Maine were used to determine the site’s season of occupation. Modern Mya arenaria were collected throughout a calendar year from a nearby clam flat in Jones Cove, Gouldsboro to establish a modern isotopic baseline to which the archaeological shell δ18O values were compared. The results indicate that the archaeological samples occurred most frequently within the modern monthly winter values ranges. Additionally, …

Effect Of Grape Components On Periodontal Disease., Juili Subodh Shivde

Electronic Theses and Dissertations

Background: Half of the adult American population (47 %) are victims of periodontitis, a chronic inflammatory disease which leads to destruction of the tissues supporting the tooth. Periodontitis is initiated by periodontal pathogens and caused by excessive or prolonged host mediated inflammation. Porphyromonas gingivalisis one important agent implicated in the etiopathogenesis of chronic periodontitis. Pro-inflammatory cytokines induced by periodontal pathogens can cause alveolar bone loss and periodontitis. Bone loss is caused by the imbalance of bone formation and bone resorption. Osteoclasts are major cells that cause bone resorption. Moreover, periodontal inflammation also leads to bone resorption. Grapes are rich …

Student Nurses’ Perception Of Sleep Quality, Nicole Wall

Electronic Theses and Dissertations

Sleep health is an underrepresented topic in the literature. Poor quality of sleep can lead to sleep deprivation, which has serious health and social consequences. The first year of university encompasses new demands and challenges to learning. Nursing students and nurses who suffer from poor sleep quality are at risk of providing unsafe patient care. The purpose of this pilot study was to explore the perceived level of sleep quality of first year nursing students. This was a descriptive, cross-sectional study that was guided by Rosenstock’s Health Belief Model. The participants completed an online survey that included the Pittsburgh Sleep …

Trace Element Analysis Of Human Dentition From The Elite Meroitic Cemetery At Sedeinga, Sudan To Determine Dietary Consumption And Cultural Behaviors, Tiffany Lee

Electronic Theses and Dissertations

Minimal research has been conducted on the human skeletal remains from this site, and this research is aimed toward adding knowledge of the Nubian culture for the period between the 1st c. AD to the 4th c. AD, particularly focusing on answering the following questions: 1) Was intra- individual variation present in dietary consumption or cultural behaviors based on elements found within an individual's multiple molars after analysis; 2) Was an inter-individual variation apparent, based on developmental age through permanent molars, that indicated a distinction between dietary consumption against all individuals; and 3) Based on known medicinal and cosmetic use …

Bridging The Gap: Community Gardens As A Supplement To Senior Adult Food Assistance Programs, Jheri-Lynn Mcswain

Electronic Theses and Dissertations

Food insecurity and access to nutrition-rich food for senior adults receiving food assistance is an ever-growing concern in the United States. For households that lack accessible food, the availability of alternative sources of nutrition such as community gardens could be critically important to maintaining a stable level of food security. The purpose of this study was to explore the feasibility of using a community garden as a supplemental food assistance tool for congregate meals sites and food pantries. This study encompassed the following three phases: 1) surveying the trends in Shelby County, Texas senior adults receiving food assistance to determine …

Cannabidiol Alters The Immune Response To Porphyromonas Gingivalis In Mice., Shilpa Singh

Electronic Theses and Dissertations

Background: Porphyromonas gingivalis is an important etiologic agent of chronic periodontitis, an infectious disease defined by destruction of supporting tissues of the teeth. Marijuana is a risk factor for chronic periodontitis, although underlying mechanisms are poorly understood. As phytocannabinoids have been ascribed antiinflammatory properties, we hypothesized that cannabidiol exposure would lead to altered immune response to P. gingivalis infection facilitating bacterial persistence and, subsequently, increased alveolar bone loss in cannabidiol (CBD)-exposed mice. Methods: P. gingivalis-infected cannabinoid receptor 2 (CB2) knockout and wild type C57/Bl6 mice were exposed, or not exposed, to cannabidiol. Oral swabs from mice were used to monitor …

Binder Jetting Additive Manufacturing Process Fundamentals And The Resultant Influences On Part Quality., Hadi Miyanaji

Electronic Theses and Dissertations

Binder jetting additive manufacturing (BJ-AM) technology is a process by which a part is fabricated layer by layer through depositing liquid binder in the designated regions of each layer until the feature is complete. Due to the use of binder in geometry generation, this process possesses various advantages over the other additive manufacturing technologies including the ability to create colored objects via colored binders, lower cost, lack of heat-induced defects, and its potential capability to print a variety of materials such as metals, sands and ceramics. Although the application of the binder jetting process has been recently reported by different …

Effects Of College-Themed Media On First-Year Student Expectations, Micheal John Clinton Jr.

Electronic Theses and Dissertations

Common expectations of incoming undergraduates have been identified, however, the influences on these expectations are varied and include input from high school, familial pressures, and the media. Incoming students consume messages regarding what college is like from these various sources, yet the specific impact of narrative media has yet to be investigated. Utilizing interviews of college students following their first full-time academic year, this study accomplishes two tasks. First, the types of expectations students have of four common assumptions of college congruent with previous research are identified. Then, the influences of narrative media are investigated and analyzed. The analysis of …

Improving Integrated Care For Medically Underserved Patients At A Texas Fqhc Using Sbirt And Phq-9, Irene Fuentes

Electronic Theses and Dissertations

Integrated Care, under provisions of the Affordable Care Act (ACA), aimed to reduce fragmented care for Medically Underserved Populations (MUPs) who depend on community-based centers for their health care needs. Well-defined by the World Health Organization, social determinants of health such as low socioeconomic status, low educational attainment, and housing instability often contribute to health disparities, making it difficult for MUPs to achieve optimal health outcomes. The purpose of this study was to gather preliminary data indicating the need to integrate a social work program at a Texas Federally Qualified Health Center using the Screening, Brief Intervention, and Referral to …

Prevention Of Child Maltreatment In U.S. Air Force Families, Amber Ester Coody

Electronic Theses and Dissertations

The Department of Defense created the Family Advocacy Program (FAP) to provide primary and secondary intervention and prevention services to military families to decrease the risks of family maltreatment. This review synthesized literature to reveal how deployment, domestic abuse, mental health, and substance abuse relate to adult and child maltreatment in the armed forces. Systematic review procedures are used to evaluate nine studies meeting inclusion criteria to correlate factors significant in the increased risk of child maltreatment. Based on results, this paper discusses how FAP can effectively provide primary and secondary services by transitioning from a traditional medical model to …

Spatial Cues Affect Neural Responses To Oddball Paradigm In The Rat’S Auditory Midbrain, Mathiang Ghai Chot

Electronic Theses and Dissertations

The ability to detect novel sounds in a natural environment has behavioral significance. For instance, novel sounds are important for predation, predator avoidance as well as inter- and intraspecific communications. One of the methods used to study novelty detection is to record neural responses to oddball paradigm. An oddball paradigm is a train of acoustic stimuli in which an oddball sound (Odd) is occasional and randomly interleaved in an otherwise repetitively presented qualitatively different standard sound (Std). Neurons sensitive to novel sounds exist in auditory structures including the auditory midbrain. This study investigated whether neurons in the auditory midbrain use …

Differences In Perceived Stress, Locus Of Control, And Coping Styles Used By Male And Female Stem And Human Service Majors, Dawn M. Lowe

Electronic Theses and Dissertations

The current study sought to determine if program type along with gender could predict the type of coping styles students are more likely to use. Secondly, it endeavored to uncover whether a college student’s gender and program type might affect their locus of control and the amount of perceived stress reported. It was hypothesized that female students in Human Service programs would exhibit the most adaptive coping styles, while males in Science, Technology, Engineering, and Mathematics (STEM) programs utilize the most maladaptive coping styles. Moreover, it was postulated that females in Human Service programs would report a more internalized locus …

A Survey Of The Implementation And Usage Of Electronic Dental Records And Digital Radiographs In Private Dental Practices In Mississippi, Barbara K. Brent

Electronic Theses and Dissertations

Implementation of electronic health records by the Health Information Technology for Economic and Clinical Health has led to the implementation of electronic dental records (EDRs) and digital radiography in dental offices. The purpose of this study was to determine the state of the implementation and usage of EDRs and digital radiographs by the private general and pediatric dental practices in Mississippi as well as reasons why the dental practices are not moving forward with the advanced technology.

A survey was emailed to 712 dental practices: 116 responded (16% response rate), and 104 consented to participate (89.66%). Results indicated dental practices …

Characterization Of Type Ii Toxin Anti-Toxin Systems In Aggregatibacter Actinomycetemcomitans., Blair W. Schneider

Electronic Theses and Dissertations

Microbes express many protective mechanisms in response to environmental stress. Toxin/anti-toxin systems encode a biologically active toxin and a labile anti-toxin that inhibits the toxin’s activity. These systems are known to contribute to persister cell and biofilm formation. A. actinomycetemcomitans thrives in the complex oral microbial community and is subjected to continual environmental flux. Little is known regarding the presence and function of TA systems in this organism or their contribution survival in the oral environment. Using BLAST searches and other informatics tools, we identified 11 intact TA systems that are conserved across all seven serotypes of A. actinomycetemcomitans and …

Factors Impacting Bone Mineral Density (Bmd) Results Of Individuals With Intellectual And Developmental Disabilities (Idd), Rhonda Mcnabb

Electronic Theses and Dissertations

Individuals with intellectual and developmental disabilities (IDD) are prone to certain diseases in their lifetime, such as osteoporosis. Absorption of calcium is essential to maintaining good bone health and preventing osteoporosis. This study examined primary care providers’ (PCPs) choice of calcium supplementation, as well as type of calcium supplementation, and the relationship between variables in the IDD population. Ten PCPs were asked to complete a 14-question web-based survey, with five surveys completed. Calcium citrate was the preferred supplement among respondents at 50%. Retrospective data was collected from patient records and included type of calcium supplement prescribed, bone density test results, …

Intraoral Imaging At Insertion Of Implant Supported Restorations At An Academic Institution : Conformity To Established Guidelines., J. Alec Power

Electronic Theses and Dissertations

The objective of this study was to establish the frequency of intraoral imaging at the time of insertion of implant supported restorations at University of Louisville School of Dentistry (ULSD). After IRB approval (14.1215), patients on whom an implant-supported single unit fixed restoration was placed were identified from the electronic health record over a 4-year period. Type of prosthesis retention (cement vs. screw) and discipline responsible for crown placement was recorded. Bitewing (BWx) or periapical (pa) images taken at the time of prosthesis placement were accessed and reviewed. Overall radiographic frequency according to modality was tallied and compared using Chi-square …

Killing Martin County : Resiliency In A Central Appalachian Community., David Adam Sizemore

Electronic Theses and Dissertations

Environmental stressors, anything that poses a threat to human and environmental health, are disproportionately located in marginalized communities. Coal extraction companies produce and concentrate environmental stressors in Central Appalachia, a sub-region of Appalachia with high poverty rates and economic hardship. Through destructive coal extraction methods, the coal industry has jeopardized Central Appalachian health and environmental quality. The coal industry’s power to cause destruction in Central Appalachia is a product of historical strategic initiatives. Since the late 1800s, the coal industry has forcefully altered the culture and ideology of Central Appalachians and developed relationships with local, state, and federal policymakers to …

Fossil Moles From The Gray Fossil Site, Tn: Implications For Diversification And Evolution Of North American Talpidae, Danielle Oberg

Electronic Theses and Dissertations

The Gray Fossil Site (GFS) is one of the richest Cenozoic terrestrial localities in the eastern United States. This study describes the first talpid specimens recovered from the GFS. Using measurements and comparisons of dental and humerus morphology, I identify 4 talpids (Parascalops nov. sp., Quyania cf. Q. europaea, Mioscalops (= Scalopoides) sp., and an unidentified stem desman) occurring at the GFS. Humeral morphology has been used to diagnose talpid species and study relationships. A geometric morphometric analysis showed that humerus shape is highly reflective of locomotor ecology in extant talpids and allows ecological inferences for fossil …

Postcranial Morphology And The Locomotor Adaptations Of Extant And Extinct Crocodylomorphs And Lepidosaurs, Laura Rooney

Electronic Theses and Dissertations

I have collected a series of linear measurements of the postcranial skeletons of 43 extant crocodylian and lepidosaur taxa to determine if those engaging in similar locomotor behavior display similar morphology despite phylogenetic differences. Stepwise discriminant function analyses reveal reptile locomotor mode can be accurately predicted (over 80% correct) based on morphology. Semi-aquatic taxa are distinguished by a longer ischium relative to pubis length, a longer scapula relative to humerus length, and a broader acetabulum than terrestrial and arboreal taxa. Arboreal taxa display a more elongate, gracile humerus and a smaller acetabulum. This morphometric data can potentially be used to …

Divergent Evolution Of Di-Lysine Er Retention Vs. Farnesylation Motif-Mediated Anchoring Of The Ankb Virulence Effector., John David Perpich

Electronic Theses and Dissertations

Legionella pneumophila is an aquatic organism capable of intracellular replication within a wide range of protozoan hosts and within human macrophages where it causes Legionnaires’ Disease. L. pneumophila manipulates a variety of host cell processes by translocating, into the host cell cytosol, more than 300 effector proteins via the type IVB secretion system (T4SS). The AnkB effector from the AA100/130b strain (AnkB-AA100) contains a C-terminal CaaX motif that rapidly becomes farnesylated upon translocation into the host cell and anchored to the cytosolic face of the Legionella-containing vacuole (LCV) membrane, which is essential for intracellular replication. We show that a …

Effect Of Porcelain Thickness And Translucency On The Final Shade Of Ips E.Max Cad Overlaying A Dark Substrate., Peter F. Alena

Electronic Theses and Dissertations

IPS e.max is a very esthetic lithium disilicate used in dental ceramics. Unfortunately, it can unintentionally change color after cementation with resin cements. The purpose of this study is to better understand how combining thickness and translucency affects the post-cementation shade of IPS e.max CAD overlaying a dark substrate, thereby enabling clinicians to choose more appropriate techniques and materials. IPS e.max CADs (A1 shade) had either a low translucency (LT) or high translucency (HT), and cut with 0.3mm, 0.5mm, and 1.0mm thicknesses. Each sample overlaid a resin cement and dark substrate, a spectrophotometer helped derive the color difference (ΔE*ab), and …

Long-Term Dental Outcomes Of The Professional Education Preparation Program., Samuel D. Petersen

Electronic Theses and Dissertations

Introduction: The Professional Education Preparation Program (PEPP) is a health careers pipeline program for Kentucky pre-health students from Health Professional Shortage Area counties and/or racial/ethnic groups underrepresented in the health professions. The purpose of this study was to determine the demographics of the dental PEPP participants and if, post dental school graduation, they were providing care for underserved patient populations Methods: PEPP dental graduates (n=114) had been previously identified. Participants were contacted by phone, asked to participate and then mailed a survey. Survey questions covered personal, practice and patient characteristics, procedures performed, insurance accepted and community outreach. Logistic regression analysis …

Development Of Blended Polymeric Fibers To Alter The Release Of Peptide Targeting Porphyromonas Gingivalis., Sonali Suresh Sapare

Electronic Theses and Dissertations

Periodontitis is a chronic inflammatory disease that infects the tissues of the periodontium. It is estimated that 47.2% or 67.2 million American adults suffer from mild, moderate and severe periodontitis. Globally, 30-50% of the adult population is afflicted with periodontal disease, making it one of the most prevalent infectious diseases in the world. Therapeutics targeting P. gingivalis may be effective to alter periodontitis progression. However, the current treatment modalities that target critical pathogens to maintain host-biofilm homeostasis are limited, urging the development of specifically targeted therapeutics to limit P. gingivalis recolonization of the oral cavity after periodontal treatment and healing. …

Gestures Of Creative Recovery For The Egocentric Actor Through Performance In Wertenbaker's Our Country's Good., Ross Joel Shenker

Electronic Theses and Dissertations

This document serves as a travelogue for the creation of two roles for the U of L Fall 2017 Production of Timberlake Wertenbaker’s Our Country’s Good. At odds throughout the process were intellect and vulnerability. In an attempt to find openness with my primary scene partner, I tried a variety of techniques including, but not limited to: Konstantin Stanislavski’s “Bits and Tasks”; Michael Chekhov’s “Psychological Gesture”; Carl Jung’s theories on Archetype; F.M. Alexander’s notions of “Inhibition” and “Nondoing” as expounded upon by Betsy Polatin; and Julia Cameron’s “Morning Pages.” My original goal of achieving vulnerability on stage became consumed …

A Systematic Review Of Rural Veteran Homelessness, Jonathan Fasse

Electronic Theses and Dissertations

This study is a systematic review to examine homeless veterans identified to be most at risk of unsuccessfully completing the VA’s housing program (HUD-VASH), which promotes the use of Housing First (HF) as it’s model for treating homelessness. The literature review identified those who were rural and experiencing comorbid substance use disorders (SUD) and mental health issues to likely be those who were most at risk. There were multiple reasons why this subgroup was most vulnerable including limited access to resources, higher levels of substance use and more serious mental health diagnoses, and chronic health needs. Both the literature review …

The Re-Certification Barriers In The United States: Comparing Refugee Professional Credentials To Texas Standards, Mary Beth Shelton

Electronic Theses and Dissertations

The purpose of this study is to explore the re-certification process for college- educated immigrants in the United States, Canada, and Texas. Underemployment is a problem among foreign trained professionals in the United States. Additionally, this study serves as a guide for the International Rescue Committee to assist future clients. The guide provides a general outline for the licensure process within three professions in Texas. A sample of 192 participants was collected from existing client files from a resettlement agency in Texas. The researcher found approximately 24% of participants were college-educated. An advanced level of English proficiency did not correlate …

An Exploration Of Barriers To Health Care Access Among Uninsured Patients: Using The Moderating Effect Of Patients’ Enablement, Enedelia L. Jessup

Electronic Theses and Dissertations

ABSTRACT On March 23, 2010, Congress passed the Patient Protection and Affordable Care Act (ACA) to increase value of care, improve clinical outcomes, decrease health care costs, and increase affordability in health care access. The purpose of the study attempts to examine the moderating effects of patient enablement impacting barriers, low socio economic status, and unmet basic needs, toward health care access in uninsured populations post ACA. Only certain aspects of patient enablement in self-management of an individual’s health care goals have been conducted with uninsured populations with barriers toward health care access. The research design was a quantitative, exploratory, …

Mechanical Characterization Of Chitosan Coating Deposited Using Electrospray Method, Ewe Jiun Chng

Electronic Theses and Dissertations

Incorporation of coating to enhance the bioactivity, anti-microbial and drug delivery capability of implant has been the interest of researchers. Chitosan is a biopolymer that exhibits these properties. In this study, electrospray method was used to coat 2D titanium substrate and titanium screw with chitosan. The focus was to compare the bond strength between the coatings produced using electrospray and solution casting method. The effect of silane-based treatment to chemically bond chitosan to the surface of titanium for better bonding was evaluated. The bond strength of the 2D coatings was evaluated using tensile and shear tests. The coating retention on …