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Articles 1 - 11 of 11
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Exploration Of Ataxia Telangiectasia And Rad3-Related’S (Atr’S) Role In Cell Death Regulation: Implications In Development, Cancer, And Stroke, Brian Cartwright
Exploration Of Ataxia Telangiectasia And Rad3-Related’S (Atr’S) Role In Cell Death Regulation: Implications In Development, Cancer, And Stroke, Brian Cartwright
Electronic Theses and Dissertations
From gametogenesis until death an organism’s genome is under constant bombardment from endogenous and exogenous sources of DNA damage. To maintain genomic integrity amid this damage, cells have evolved responses which allow them to either preserve viability for recovery or initiate self-destructive pathways depending on the severity of DNA damage. One protein involved in initiating and carrying out these responses is the protein kinase ataxia telangiectasia and Rad3-related (ATR). ATR is known primarily for its regulatory role in initiating the checkpoint-signaling cascade following DNA damage and replicative stress. These signaling events lead to cell cycle arrest, DNA repair, or apoptosis …
Preparation Of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles As Targeting Tumor Theranostics, Samson Dada
Preparation Of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles As Targeting Tumor Theranostics, Samson Dada
Electronic Theses and Dissertations
Carbon dots (CDs) have attracted much attention as an excellent gene/drug delivery and biological imaging agent for early cancer theranostics. In this study, we prepared two series of nanoparticles (NPs), which are composed of (CDs) with a targeting agent, folic acid (FA), and a chemotherapeutic agent Doxorubicin (Dox). All the NPs and their intermediates were characterized using ultraviolet-visible spectroscopy (UV-vis), fluorescence spectroscopy, and Fourier transform-infrared spectroscopy (FT-IR). The drug loading capacity (DLC) and drug loading efficiency (DLE) of two series of FA-CDs-Dox were assessed using UV-vis absorption spectroscopy at the wavelength of 485 nm. Both showed good DLE and DLC …
Investigation Of Phosphoserine Aminotransferase 1(Psat1) In Breast Cancer Progression., Stephanie Metcalf
Investigation Of Phosphoserine Aminotransferase 1(Psat1) In Breast Cancer Progression., Stephanie Metcalf
Electronic Theses and Dissertations
This dissertation describes my research into the involvement of phosphoserine aminotransferase 1 (PSAT1) in breast cancer progression; specifically, in triple negative breast cancer (TNBC) metastasis and endocrine resistance in estrogen receptor positive breast cancer (ER+BC). Breast cancer is the most common tumor diagnosis among women. While the overall 5-year survival for breast cancer is reaching 90%, the 5-year survival for metastatic disease is only 22%. Metastasis and endocrine resistance combined can affect over 50% of patients. One of the proteins and pathways implicated in both metastasis and endocrine resistance in breast cancer is phosphoserine aminotransferase 1 (PSAT1) and the serine …
Analysis Of Tobacco Use Vital Sign Assessment, Latonya King
Analysis Of Tobacco Use Vital Sign Assessment, Latonya King
Electronic Theses and Dissertations
There is a massive problem of tobacco-related cancer outcomes in patients that are affected by race and ethnicity. Although this is a known disparity, there continues to be a gap in care for asking patients if they use tobacco and in advising and assisting them in making a quit attempt. Health information technology requirements and meaningful use regulations require the utilization of systematic electronic documentation. In order to improve and support tobacco use screening, systematic tobacco use assessment and documentation are essential. There is a widespread belief that adding screening for tobacco use to the vital sign assessment will lead …
The Role Of Social Supports On The Financial Toxicity Of Cancer., Lisa C. Smith
The Role Of Social Supports On The Financial Toxicity Of Cancer., Lisa C. Smith
Electronic Theses and Dissertations
Although literature exists on the impact of cancer-related financial burden and its effects on quality of life, we do not have a full understanding of the nature of the financial burden on individuals and their families. Likewise, research on social support has concentrated on social, emotional, functional, and physical well-being but not on the financial well-being of individuals with cancer. The purpose of this study is to understand the role of social support in the relationship between financial toxicity and quality of life of individuals living with cancer. This research used a multiple method approach composed of two studies. Study …
Synthesis, Characterization, And Evaluation Of Metal Complexes With Cancer Selective Anti-Proliferative Effects And Hydrogen Evolution Catalytic Properties., Nicholas Vishnosky
Synthesis, Characterization, And Evaluation Of Metal Complexes With Cancer Selective Anti-Proliferative Effects And Hydrogen Evolution Catalytic Properties., Nicholas Vishnosky
Electronic Theses and Dissertations
Bis-thiosemicarbazones (BTSC) and their metal chelates have properties that are useful in several different scientific fields. These systems have already received attention in major fields of biology and engineering. Hydrogen evolution reaction (HER) catalysts need to be cheap and operate under minimal overpotentials with a long lifetime. The treatment of cancer requires, novel agents that have potent cytotoxic activity against cancer cells while displaying minimal side effects. In this dissertation the modular synthesis of these bis-thiosemicarbazone systems is utilized to regulate the redox chemistry for employment in the desired sector of chemistry. The ligand and metal chelates synthesized were characterized …
Paraoxonase 2 Is Critical For Non-Small Cell Lung Carcinoma Proliferation., Aaron Whitt
Paraoxonase 2 Is Critical For Non-Small Cell Lung Carcinoma Proliferation., Aaron Whitt
Electronic Theses and Dissertations
Non-small cell lung carcinoma (NSCLC) comprises 85% of lung cancer diagnoses and is plagued by drug resistance. Thus, elucidating the underlying mechanisms of NSCLC is paramount to expand future treatment options. Paraoxonase 2 (PON2), an intracellular enzyme with arylesterase and lactonase functions, has well-established anti-atherosclerotic activity. Recent studies show PON2 is overexpressed in a variety of tumors and confers drug resistance, although these interactions have not been thoroughly examined in NSCLC. Thus, we sought to investigate the role of PON2 in cellular proliferation using PON2-knockout mice, primary mouse cells, and NSCLC cell lines. Using these approaches, we demonstrate that PON2 …
Implications Of Functional Limitations In Older Cancer Survivors A Medicare Beneficiary Survey, Prachi Chavan
Implications Of Functional Limitations In Older Cancer Survivors A Medicare Beneficiary Survey, Prachi Chavan
Electronic Theses and Dissertations
The purpose of this dissertation was to evaluate the impact of physical and functional limitations among older cancer survivors and its effect on healthcare utilization and mortality among them. The Medicare Current Beneficiary Survey (MCBS) is nationally representative longitudinal study of older Medicare beneficiaries. Physical Limitations (PL), Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL) were measured on a five-point scale. MCBS data from 2005 to 2013 were used in this study. Propensity score weighting was developed using logistic regressions. Design-based descriptive analysis and logistic models with adjusted survey weights were performed. Logistic and Poisson regression …
Essays On Health, Labor And Public Economics, Ahmad Reshad Osmani
Essays On Health, Labor And Public Economics, Ahmad Reshad Osmani
Electronic Theses and Dissertations
This Dissertation consists of three essays on health, labor, and public economics. The first essay investigates how gender-specific cancers affect the labor market outcomes of cancer survivors. Using a theoretical construct of labor supply and health capital, this essay exploits a nationally representative dataset, the 20082015 Medical Expenditure Panel Survey (MEPS), for estimating the correlated random effects (CRE) and over-dispersion empirical models to capture the job market effects for cancer survivors. After addressing the potential endogeneity of cancer and controlling for the number of years after cancer diagnoses, the estimated CRE model detect substantial male-female differences in the labor market …
Characterizing Phenotypic Effects Of Spy1 Mediated Lateral Branching, Iulian Eric Derecichei
Characterizing Phenotypic Effects Of Spy1 Mediated Lateral Branching, Iulian Eric Derecichei
Electronic Theses and Dissertations
Mammary development is a continuous and cyclic process that is under tight regulatory control from hormones and cell cycle regulators to mediate transition from the various proliferative, differential and apoptotic steps. Puberty is a time-point of high proliferation during development that has higher susceptibility to breast cancer. Spy1 is a cyclin-like protein known to regulate mammary development and increase proliferation with previous work also showing Spy1 increases tumor susceptibility and pubertal lateral side branching. ¬In this work we demonstrate that elevated levels of Spy1 in puberty significantly increase the number of lateral branches and total epithelial content in mice. Similarly, …
Anticancer Activity Of Natural Health Products (Dandelion Root, Lemongrass, And Hibiscus Extracts); A Study Of Efficacy, Interaction, And Mechanism Of Action, Christopher Vu Nguyen
Anticancer Activity Of Natural Health Products (Dandelion Root, Lemongrass, And Hibiscus Extracts); A Study Of Efficacy, Interaction, And Mechanism Of Action, Christopher Vu Nguyen
Electronic Theses and Dissertations
Cancer continues to be the leading cause of death in Canada. Many conventional chemotherapies have indicated side effects due to a lack of treatment specificity and are thus not suitable for long-term usage. Natural health products (NHPs) are well-tolerated and safe for consumption, and some have pharmaceutical uses particularly for their anti-cancer effects. We have previously investigated the anti-cancer efficacy of dandelion (Taraxacum officinale) root, lemongrass (Cymbopogon citratus), and hibiscus (Hibiscus syriacus) extracts. However, their efficacy on prostate, colorectal, and breast cancer as well as their interactions with standard chemotherapeutics have not been studied to determine if they will be …