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Augmentation Of Ras-Induced Cell Transformation : A New Role For Mir-200a In Malignancy., Lindsey Erin Becker
Augmentation Of Ras-Induced Cell Transformation : A New Role For Mir-200a In Malignancy., Lindsey Erin Becker
Electronic Theses and Dissertations
Cancer is a multistep disease that begins with malignant cell transformation and frequently culminates in metastasis and death. MicroRNAs (miRNAs) are small regulatory 21-25-nt RNA molecules and are frequently deregulated in cancer. The majority of miRNAs are estimated to be co-expressed with neighboring miRNAs as clusters. Many miRNA clusters coordinately regulate multiple members of cellular signaling pathways or protein interaction networks. miR-200a is a member of the miR-200 family, which are known to be strong inhibitors of the epithelial to mesenchymal transition. As such, the tumor suppressive role of miR-200a in oncogenesis has been well studied; however, recent studies have …
Treatment-Related Decisional Conflict, Quality Of Life, And Comorbid Illness In Older Adults With Cancer, Jeannette Kates
Treatment-Related Decisional Conflict, Quality Of Life, And Comorbid Illness In Older Adults With Cancer, Jeannette Kates
Electronic Theses and Dissertations
As the aging population the nation increases, cancer diagnoses in this age group will also increase. The many chronic medical conditions associated with older adults will be confounded by a diagnosis of cancer. Older adults with cancer are at risk for physical, psychological, and functional decline as a result of not only the cancer, but also the cancer treatment. This study utilized a cross-sectional, descriptive, correlational study design to explore the relationships between and among treatment-related decisional conflict, quality of life and comorbidity in older adults with cancer. An anonymous survey method was employed. The criteria for inclusion in this …
Anticancer Activity Of Natural Health Products (Dandelion Root & Long Pepper Extracts); Extensive Study Of Efficacy And Mechanism Of Action, Pamela Ovadje
Electronic Theses and Dissertations
The incidence of cancer worldwide is continuously on the rise, and the death toll associated with cancer, is constantly increasing. Available cancer therapy is unable to combat this ever-changing disease, and the severe side effects associated with various forms of therapy, indicate a serious need for the development of more effective and safer alternatives to currently available treatment. The use of natural health products in disease treatment has contributed to the development of over 75% of available chemotherapy. In this thesis, we study the potential anti-cancer effect of two natural health products, dandelion root and long pepper extracts. The major …
The Polo-Like Kinases As Recipients And Enablers Of Epigenetic Modifications In Tumourigenesis, Rosa Alejandra Ward
The Polo-Like Kinases As Recipients And Enablers Of Epigenetic Modifications In Tumourigenesis, Rosa Alejandra Ward
Electronic Theses and Dissertations
Many highly conserved proteins have evolved specific niches in the cell cycle. For the Polo-like kinases (PLKs), these roles include centrosome duplication and maturation, the interaction with key DNA damage response proteins, cytokinesis, and chromosome separation. The PLKs deliver their effects via phosphorylation of their substrates at serine and threonine residues. Due to their importance in the cell cycle, expression of the PLKs is strictly governed. PLK deregulation is ubiquitously associated with malignancy. Elucidating how these proteins are regulated is key to understanding how their proper function can be restored in tumourigenesis. In recent years, the study of epigenetics as …