Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
On The Construction And Interpretation Of Fitness Landscapes For Hiv: A Computational Perspective, Elizabeth Grace Johnson
On The Construction And Interpretation Of Fitness Landscapes For Hiv: A Computational Perspective, Elizabeth Grace Johnson
Doctoral Dissertations
To identify vulnerable viral targets to incorporate into an immunogen, fitness landscapes for the viral proteome have been constructed. These landscapes describe the sum or synergistic replicative cost exacted on the virus for any combination of non-synonymous mutations. Here we attempt to assess the robustness of current computational methods for measuring the fitness cost of HIV polymorphisms in these landscapes. We also address in the following chapters assumptions and shortcomings that may underlie current landscape's uneven ability to predict fitness effects.
In the first chapter, I appraise the robustness of current frame-works that derive fitness costs from patient sequence data. …
Hiv-Related Stigma And Health Among People Living With Hiv In Middle Georgia: Examining The Roles Of Stress And Coping, Kaylee Burnham
Hiv-Related Stigma And Health Among People Living With Hiv In Middle Georgia: Examining The Roles Of Stress And Coping, Kaylee Burnham
Doctoral Dissertations
Objective – HIV-related stigma and discrimination are drivers of health disparities among people living with HIV (PLWH). The U.S. South bears much of the burden of the domestic HIV epidemic. This study seeks to explore the dynamic effects of HIV-related stigma on health outcomes in a population of PLWH in middle Georgia. Experiences of enacted HIV stigma in the past year were assessed and participants indicated how stressful these events were and how they coped with the most impactful event. The primary study aim tested a moderated serial mediation model of HIV stigma on health in this population.
Method – …