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Psychological And Genetic Contributions To The Development Of Social Cognition In Children, Jacqueline Marie Klaver
Psychological And Genetic Contributions To The Development Of Social Cognition In Children, Jacqueline Marie Klaver
Dissertations
This study examined the development of social cognition in children with and without autism spectrum disorder (ASD), as well as the influence of behavioral and molecular genetics on these higher-order cognitive abilities. Specifically, it was hypothesized that children with ASD would perform more poorly on all social cognitive tasks compared with typically developing peers. In addition, it was hypothesized that typically developing children who performed better on a simpler social cognitive task at ages 3 or 4 would perform better at follow-up (i.e., one time between the ages of 6-10). Lastly, it was hypothesized that children who had at least …
Population Genetics And Microbial Communities Of The Gopher Tortoise (Gopherus Polyphemus), Daniel Lyle Gaillard
Population Genetics And Microbial Communities Of The Gopher Tortoise (Gopherus Polyphemus), Daniel Lyle Gaillard
Dissertations
The gopher tortoise, Gopherus polyphemus, is an endangered species living in the southeastern United States. The recent and drastic decline in tortoise numbers has resulted in a multi-faceted approach to conserve this species. I used a population genetic approach to determine the population structure, genetic diversity and barriers to gene flow at a broad, regional and local scale. Tortoises are divided into five distinct genetic populations at the broad scale, the central populations have the highest levels of genetic diversity and the Tombigbee, Mobile, Apalachicola, Suwannee and St. John’s Rivers appear to be barriers to gene flow. At the regional …
Pattern Specific Isotopic Labeling Of Phenylalanine And Incorporation Into Recombinant Protein For Macromolecular Complex Study, Mary Catherine Hames
Pattern Specific Isotopic Labeling Of Phenylalanine And Incorporation Into Recombinant Protein For Macromolecular Complex Study, Mary Catherine Hames
Dissertations
Macromolecular complexes are at the forefront of structural biology. Despite technological advances, there remains a significant size barrier for study of these systems. Site specific labeling of ILV methyl residues has been used to study systems such as the proteasome, but other methods are still needed. Aromatic amino acids have many of the advantages of methyl containing residues and are desirable for site specific labeling. They are often found in the protein core and at important interaction interfaces. Aromatic side chains have positions with multiple magnetically equivalent 1H probes and distinct carbon chemical shifts. Side chain ring flipping results in …