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Cannabinoid Conditioned Reward And Aversion: Behavioral And Neural Processes, Jennifer E. Murray, Rick A. Bevins
Cannabinoid Conditioned Reward And Aversion: Behavioral And Neural Processes, Jennifer E. Murray, Rick A. Bevins
Department of Psychology: Faculty Publications
The discovery that delta-9-tetrahydrocannabinol
(Δ9-THC) is the primary psychoactive ingredient in
marijuana prompted research that helped elucidate
the endogenous cannabinoid system of the brain.
Δ9-THC and other cannabinoid ligands with agonist
action (CP 55,940, HU210, and WIN 55,212-2)
increase firing of dopamine neurons and increase
synaptic dopamine in brain regions associated with
reward and drug addiction. Such changes in cellular
processes have prompted investigators to examine
the conditioned rewarding effects of the cannabinoid
ligands using the place conditioning task with rats and
mice. As reviewed here, these cannabinoid ligands
can condition place preferences (evidence for rewarding …