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Determination Of Critical Nucleation Number For A Single Nucleation Amyloid-Β Aggregation Model, Preetam Ghosh, Ashuwin Vaidya, Amit Kumar, Vijayaraghavan Rangachari
Determination Of Critical Nucleation Number For A Single Nucleation Amyloid-Β Aggregation Model, Preetam Ghosh, Ashuwin Vaidya, Amit Kumar, Vijayaraghavan Rangachari
Department of Mathematics Facuty Scholarship and Creative Works
Aggregates of amyloid-β (Aβ) peptide are known to be the key pathological agents in Alzheimer disease (AD). Aβ aggregates to form large, insoluble fibrils that deposit as senile plaques in AD brains. The process of aggregation is nucleation-dependent in which the formation of a nucleus is the rate-limiting step, and controls the physiochemical fate of the aggregates formed. Therefore, understanding the properties of nucleus and pre-nucleation events will be significant in reducing the existing knowledge-gap in AD pathogenesis. In this report, we have determined the plausible range of critical nucleation number (n*, the number of monomers associated within the nucleus …