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Investigating The Spectrum Of Biological Activity Of Ring-Substituted Salicylanilides And Carbamoylphenylcarbamates, Jiahui Guo, Aidan Coffey, Et. Al.
Investigating The Spectrum Of Biological Activity Of Ring-Substituted Salicylanilides And Carbamoylphenylcarbamates, Jiahui Guo, Aidan Coffey, Et. Al.
Department of Biological Sciences Publications
In this study, a series of twelve ring-substituted salicylanilides and carbamoylphenylcarbamates were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Moreover, their site of action in the photosynthetic apparatus was determined. Primary in vitro screening of the synthesized compounds was also performed against mycobacterial, bacterial and fungal strains. Several compounds showed biological activity comparable with or higher than the standards 3-(3,4-dichlorophenyl)-1,1-dimethylurea, isoniazid, penicillin G, ciprofloxacin or fluconazole. The most active compounds showed minimal anti-proliferative activity …