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Design And Synthesis Of Small-Molecule Inhibitors Of The Hypoxia Inducible Factor-1 As Anticancer Therapeutics, Zeus Allen O. De Los Santos

Chemistry Theses

Throughout history, cancer has been severely plaguing mankind; the search for a

cure to cancer had long been sought by scientists and still poses as one of the

greatest challenges scientists have yet to overcome. Hypoxia in cells is a condition

where there is little to no oxygen availability in its environment. In general, this event

is detrimental since this can lead to cell necrosis or reoxygenation injuries. However,

hypoxia, a prominent property of most solid tumors, activates the hypoxia-inducible

factor (HIF-1) family of transcription factors that promotes angiogenesis. In this

study, we describe the design and synthesis of small-molecule …