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Investigating Differing Degrees Of Foxo3a Expression In Adult Neural Stem Cells Between Age Groups In Zebrafish, Francis G. Bacik
Investigating Differing Degrees Of Foxo3a Expression In Adult Neural Stem Cells Between Age Groups In Zebrafish, Francis G. Bacik
Cal Poly Humboldt theses and projects
One factor influencing organismal longevity is the activity of transcription factors of the “fork head domain” family, otherwise known as “Forkhead box” (Fox) proteins. Studies of the four isoforms of the “O” subclass of Fox proteins found in human genes have revealed a direct relationship between FoxO3a-dependent gene expression and the conservation of neural stem cell (NSC) in the adult brain, specifically in the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone of the cortex. This transcription factor has also been shown to regulate apoptosis in nervous tissue during embryonic development in zebrafish. The current …
The Developmental Implications Of The Regulatory Relationship Between Cjun And Oct4 In Murine Embryonic Stem Cells, Rachel E. Brewer
The Developmental Implications Of The Regulatory Relationship Between Cjun And Oct4 In Murine Embryonic Stem Cells, Rachel E. Brewer
Cal Poly Humboldt theses and projects
As cells transition from the point of fertilization through the process of embryonic development, many molecular changes occur that affect cell fate. At the blastocyst stage, the earliest distinction, two separate cell populations arise. The trophectoderm cells will generate all of the extraembryonic tissues while the inner cell mass will yield all of the embryonic tissues. These cells, which generate the organism, are termed pluripotent at this stage and found within the inner cell mass (ICM). A variety of genetic mechanisms that regulate this event have been characterized. Here, we examined the effect of cJun expression in regulating Oct4, a …