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Genetic Contributions To Brain Fiber Architecture And Neuroanatomical Alterations In Alcohol Dependent Individuals : A Correlation Study, Vibhati Kulkarny
Genetic Contributions To Brain Fiber Architecture And Neuroanatomical Alterations In Alcohol Dependent Individuals : A Correlation Study, Vibhati Kulkarny
Biomedical Sciences ETDs
Alcohol dependence (AD) is a complex addictive disorder, affecting 5.4% of the general population during a lifetime (Kessler, 2005) and has a complex heterogenous phenotype, with behavioral, morphological, and genetic components. Alcohol use can cause gray matter and white matter tissue damage. The extent of alcoholisms effect on brain matter structure in young adults is less known. Assessement of low and high alcohol dependent individuals was derived from DSM-IV. FSL based Magnetic Resonance Imaging (MRI) and quantitative fiber tracking derived from diffusion tensor imaging (DTI) assessed morphological alterations of 6 gray matter structures involved in addiction and 10 white matter …