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Advances In Cartilage Tissue Engineering Using Bioinks With Decellularized Cartilage And Three-Dimensional Printing, Roxanne N. Stone, Jonathon C. Reeck, Julia Thom Oxford
Advances In Cartilage Tissue Engineering Using Bioinks With Decellularized Cartilage And Three-Dimensional Printing, Roxanne N. Stone, Jonathon C. Reeck, Julia Thom Oxford
Biology Faculty Publications and Presentations
Osteoarthritis, a chronic, debilitating, and painful disease, is one of the leading causes of disability and socioeconomic burden, with an estimated 250 million people affected worldwide. Currently, there is no cure for osteoarthritis and treatments for joint disease require improvements. To address the challenge of improving cartilage repair and regeneration, three-dimensional (3D) printing for tissue engineering purposes has been developed. In this review, emerging technologies are presented with an overview of bioprinting, cartilage structure, current treatment options, decellularization, bioinks, and recent progress in the field of decellularized extracellular matrix (dECM)–bioink composites is discussed. The optimization of tissue engineering approaches using …
Low Intensity Vibrations Augment Mesenchymal Stem Cell Proliferation And Differentiation Capacity During In Vitro Expansion, Guniz Bas, Stacie Loisate, Stephanie F. Hudon, Kali Woods, Eric J. Hayden, Xinzhu Pu, Richard Beard, Julia T. Oxford, Gunes Uzer
Low Intensity Vibrations Augment Mesenchymal Stem Cell Proliferation And Differentiation Capacity During In Vitro Expansion, Guniz Bas, Stacie Loisate, Stephanie F. Hudon, Kali Woods, Eric J. Hayden, Xinzhu Pu, Richard Beard, Julia T. Oxford, Gunes Uzer
Biology Faculty Publications and Presentations
A primary component of exercise, mechanical signals, when applied in the form of low intensity vibration (LIV), increases mesenchymal stem cell (MSC) osteogenesis and proliferation. While it is generally accepted that exercise effectively combats the deleterious effects of aging in the musculoskeletal system, how long-term exercise affects stem cell aging, which is typified by reduced proliferative and differentiative capacity, is not well explored. As a first step in understanding the effect of long-term application of mechanical signals on stem cell function, we investigated the effect of LIV during in vitro expansion of MSCs. Primary MSCs were subjected to either a …
Aryl Hydrocarbon Receptor Activation By Tcdd Modulates Expression Of Extracellular Matrix Remodeling Genes During Experimental Liver Fibrosis, Cheri L. Lamb, Giovan Cholico, Daniel E. Perkins, Michael T. Fewkes, Julia T. Oxford, Trevor J. Lujan, Erica E. Morrill, Kristen A. Mitchell
Aryl Hydrocarbon Receptor Activation By Tcdd Modulates Expression Of Extracellular Matrix Remodeling Genes During Experimental Liver Fibrosis, Cheri L. Lamb, Giovan Cholico, Daniel E. Perkins, Michael T. Fewkes, Julia T. Oxford, Trevor J. Lujan, Erica E. Morrill, Kristen A. Mitchell
Biology Faculty Publications and Presentations
The aryl hydrocarbon receptor (AhR) is a soluble, ligand-activated transcription factor that mediates the toxicity of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD). Increasing evidence implicates the AhR in regulating extracellular matrix (ECM) homeostasis. We recently reported that TCDD increased necroinflammation and myofibroblast activation during liver injury elicited by carbon tetrachloride (CCl4).However, TCDD did not increase collagen deposition or exacerbate fibrosis in CCl4-treated mice, which raises the possibility that TCDD may enhance ECM turnover. The goal of this study was to determine how TCDD impacts ECM remodeling gene expression in the liver. Male C57BL/6 mice were treated for …