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Presynaptic Depression In Phasic Motor Nerve Terminals And Influence Of 5-Ht On Vesicle Dynamics, A. F. M. Johnstone, S. S. Kellie, Robin L. Cooper
Presynaptic Depression In Phasic Motor Nerve Terminals And Influence Of 5-Ht On Vesicle Dynamics, A. F. M. Johnstone, S. S. Kellie, Robin L. Cooper
Biology Faculty Publications
Synaptic depression that is induced by electrical stimulation of the glutamatergic neuromuscular junction (NMJ) of the crayfish can be offset by recruitment of vesicles from a presynaptic reserve pool. This recruitment occurs following treatment of the NMJ with serotonin (5-HT), which results in a delay in the onset of synaptic depression induced by high frequency stimulation. The results of this study demonstrate that the releasable vesicles are insufficiently replenished during high frequency stimulation and that the readily releasable pool of vesicles (RRP) can be enhanced by the reserve pool (RP) in the presence of 5-HT. Anatomical visualization of vesicular pools …