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Personality Pathology And Cognitive Aging: The Role Of Interpersonal Stress, Patrick Joseph Cruitt
Personality Pathology And Cognitive Aging: The Role Of Interpersonal Stress, Patrick Joseph Cruitt
Arts & Sciences Electronic Theses and Dissertations
Research on the relationship between normal-range personality and cognitive aging has demonstrated consistent, but modest, effects. The current investigation seeks to increase our understanding of unhealthy cognitive aging by examining the maladaptive extremes of personality. Borderline and avoidant personality disorder (PD), but not obsessive-compulsive PD, were hypothesized to show prospective associations with cognitive aging. Interpersonal stress was expected to mediate these relationships. The current investigation tested these hypotheses in two longitudinal studies of older adulthood: the Alzheimer’s Disease Research Center cohort (ADRC, N = 434, Mage = 69.95, 56% women) and the St. Louis Personality and Aging Network study (SPAN, …
Dedicated Interneuronal Microcircuits Regulated By Behavioral State, Moises William Arriaga
Dedicated Interneuronal Microcircuits Regulated By Behavioral State, Moises William Arriaga
Arts & Sciences Electronic Theses and Dissertations
The hippocampus is a critical brain structure for learning and memory. Neuronal inhibition within the hippocampus, performed by a wide variety of inhibitory interneuron subtypes, is required to organize and regulate the cell activity and circuit operations which underly memory formation. Despite the importance of inhibitory interneurons to the function of the hippocampus, detailed descriptions of the role of interneurons in the regulation of network activity have been limited by difficulties associated with identifying and recording from these cells using traditional electrophysiology techniques, especially in awake, behaving animals. To better investigate the function of hippocampal interneurons in awake, behaving animals, …
Sex Differences In The Role Of Cornichon Homolog-3 On Spatial Memory And Synaptic Plasticity, Hannah Elizabeth Frye
Sex Differences In The Role Of Cornichon Homolog-3 On Spatial Memory And Synaptic Plasticity, Hannah Elizabeth Frye
Arts & Sciences Electronic Theses and Dissertations
Cornichon homolog-3 (CNIH3) is an AMPA receptor (AMPAR) auxiliary protein highly expressed in the dorsal hippocampus (dHPC), a region where AMPARs are critical for spatial memory and synaptic plasticity. A 2016 genome-wide association study (GWAS) by Nelson et al. identified single nucleotide polymorphisms (SNPs) in the gene CNIH3 to be associated with reduced individual risk for the development of opioid use disorder (OUD) in individuals with prior opioid exposure. We previously demonstrated a key role for AMPARs in the dHPC in opioid-associated learning and memory, therefore we hypothesized that CNIH3 in the dHPC may mediate learning and memory processes through …
The Counter-Discourses Of Fictional And Autofictional Contemporary German Refugee Narratives: The Slow Violence Of Postponement, Bethany Morgan
The Counter-Discourses Of Fictional And Autofictional Contemporary German Refugee Narratives: The Slow Violence Of Postponement, Bethany Morgan
Arts & Sciences Electronic Theses and Dissertations
Whereas the public discourses surrounding refugees encompass notions of legitimacy and proving the need for asylum, potential for an individual to enact violence on the host community or country as well as integration and standards for measuring individual integration, the discourse and language used by the refugee figures themselves focuses on issues of self-representation, loss and various wrongs done to themselves. These fictional and autofictional texts position the refugee figure in light of their identity, their loss(es) and the ways they have endured wrongdoing to their physical persons either through violence and imprisonment or through overly rigorous or disorganized bureaucratic …