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Articles 1 - 30 of 38
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Tbx2 Represses Pten In Rhabdomyosarcoma And Skeletal Muscle., B Zhu, M Zhang, E M Williams, C Keller, A Mansoor, J K Davie
Tbx2 Represses Pten In Rhabdomyosarcoma And Skeletal Muscle., B Zhu, M Zhang, E M Williams, C Keller, A Mansoor, J K Davie
Articles
Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children that shares many features of developing skeletal muscle. TBX2, a T-box family member, is highly upregulated in tumor cells of both major RMS subtypes where it functions as an oncogene. TBX2 is a repressor that is often overexpressed in cancer cells and functions in bypassing cell growth control, including the repression of the cell cycle regulators p14 and p21. We have found that TBX2 directly represses the tumor-suppressor phosphatase and tensin homolog (PTEN) in both RMS and normal muscle. Exogenous expression of TBX2 in normal muscle cells downregulates PTEN, …
Federal Sentencing Guidelines & United States V. Booker: Social Context And Sentencing Disparity, Jeffrey Nowacki
Federal Sentencing Guidelines & United States V. Booker: Social Context And Sentencing Disparity, Jeffrey Nowacki
Articles
The United States v. Booker (2005) decision rendered Federal Sentencing Guidelines advisory rather than mandatory. In the context of this decision, this study examines both the direct influence of aggregate-level political, community and administrative variables on sentencing outcomes, and the way that such characteristics might contextualize individual-level predictors. Using multi-level regression techniques, this study examines the role of aggregate level variables on sentence length decisions across four distinct time periods. Moreover, this article also examines whether aggregate-level variables condition the effects of race/ethnicity on sentencing outcomes. While the direct effects of aggregate-level variables on sentencing outcomes are generally limited to …
Geographies Of Inequality: Urban Renewal And The Race, Gender, And Class Of Post-Katrina New Orleans, Shiloh L. Deitz, Kristen M. Barber
Geographies Of Inequality: Urban Renewal And The Race, Gender, And Class Of Post-Katrina New Orleans, Shiloh L. Deitz, Kristen M. Barber
Articles
In this paper, we address pressing questions on the perpetuation of race, gender, and class inequalities in ongoing restoration practices shaping the "New" New Orleans. We unpack federal and local efforts to rebuild and revitalize the city over the last ten years and map the geography of New Orleans at the neighborhood level both before and after the storm. We discuss how mismanaged resources, corrupt profit-taking, conflicts of interest for the stakeholders, and socially unconscious design conditioned a fiscally irresponsible and non-inclusive recovery. These efforts have pushed out already marginalized populations, resulted in the gentrification of historically African American neighborhoods, …
Compulsive Buying And Branding Phenomena, Seung-Hee Lee, Jane Workman
Compulsive Buying And Branding Phenomena, Seung-Hee Lee, Jane Workman
Articles
The purpose of this paper was to explore the impact of brand variables such as brand awareness, brand loyalty, brand attachment, and perceived brand quality on compulsive buying behavior. A self-administered questionnaire, containing demographic items and items related to compulsive buying, brand awareness, brand loyalty, brand attachment and perceived quality, was used to collect data. Participants were 269 US university students at a large mid-western university (138 men, 131 women; mean age = 21.96). Data were analyzed using descriptive statistics, t-test and MANOVA/ANOVA. Reliability of all scales was acceptable. In the current study, 18% of the participants were classified as …
Fatigue Modeling Via Mammalian Auditory System For Prediction Of Noise Induced Hearing Loss, Pengfei Sun, Jun Qin, Kathleen Campbell
Fatigue Modeling Via Mammalian Auditory System For Prediction Of Noise Induced Hearing Loss, Pengfei Sun, Jun Qin, Kathleen Campbell
Articles
Noise induced hearing loss (NIHL) remains as a severe health problem worldwide. Existing noise metrics and modeling for evaluation of NIHL are limited on prediction of gradually developing NIHL (GDHL) caused by high-level occupational noise. In this study, we proposed two auditory fatigue based models, including equal velocity level (EVL) and complex velocity level (CVL), which combine the high-cycle fatigue theory with the mammalian auditory model, to predict GDHL. The mammalian auditory model is introduced by combining the transfer function of the external-middle ear and the triple-path nonlinear (TRNL) filter to obtain velocities of basilar membrane (BM) in cochlea. The …
Laboratory Scale Optimization Of Alkali Pretreatment For Improvingenzymatic Hydrolysis Of Sweet Sorghum Bagasse, Arosha L. Umagiliyage, Ruplal Choudhary, Yanna Liang, John Haddock, Dennis G. Watson
Laboratory Scale Optimization Of Alkali Pretreatment For Improvingenzymatic Hydrolysis Of Sweet Sorghum Bagasse, Arosha L. Umagiliyage, Ruplal Choudhary, Yanna Liang, John Haddock, Dennis G. Watson
Articles
Sweet sorghum has been identified as a promising feedstock for biological conversion to fuels as wellas other chemicals. The lignocellulosic stalk of sweet sorghum, called sweet sorghum bagasse (SSB) isa potential source of lignocellulosic biofuel. The primary goal of this study was to determine optimalalkali (lime: Ca(OH)2and lye: NaOH) pretreatment conditions to obtain higher yield of total reducingsugar while reducing the lignin content for biofuel production from SSB. Biomass conversion and ligninremoval were simultaneously optimized through four quadratic models analyzed by response surfacemethodology (RSM). The optimal conditions for lime pretreatment was 1.7% (w/v) lime concentration,6.0% (w/v) SSB loading, 2.4 h …
Evidence That The Dna Mismatch Repair System Removes 1-Nucleotide Okazaki Fragment Flaps., Lyudmila Y Kadyrova, Basanta K Dahal, Farid A Kadyrov
Evidence That The Dna Mismatch Repair System Removes 1-Nucleotide Okazaki Fragment Flaps., Lyudmila Y Kadyrova, Basanta K Dahal, Farid A Kadyrov
Articles
The DNA mismatch repair (MMR) system plays a major role in promoting genome stability and suppressing carcinogenesis. In this work, we investigated whether the MMR system is involved in Okazaki fragment maturation. We found that in the yeast Saccharomyces cerevisiae, the MMR system and the flap endonuclease Rad27 act in overlapping pathways that protect the nuclear genome from 1-bp insertions. In addition, we determined that purified yeast and human MutSα proteins recognize 1-nucleotide DNA and RNA flaps. In reconstituted human systems, MutSα, proliferating cell nuclear antigen, and replication factor C activate MutLα endonuclease to remove the flaps. ATPase and endonuclease …
Genetic Models For The Study Of Luteinizing Hormone Receptor Function, Prema Narayan
Genetic Models For The Study Of Luteinizing Hormone Receptor Function, Prema Narayan
Articles
The luteinizing hormone/chorionic gonadotropin receptor (LHCGR) is essential for fertility in men and women. LHCGR binds luteinizing hormone (LH) as well as the highly homologous chorionic gonadotropin. Signaling from LHCGR is required for steroidogenesis and gametogenesis in males and females and for sexual differentiation in the male. The importance of LHCGR in reproductive physiology is underscored by the large number of naturally occurring inactivating and activating mutations in the receptor that result in reproductive disorders. Consequently, several genetically modified mouse models have been developed for the study of LHCGR function. They include targeted deletion of LH and LHCGR that mimic …
Applications And Comparison Of Continuous Wavelets Transforms On Analysis Of A-Wave Impulse Noise, Jun Qin, Pengfei Sun
Applications And Comparison Of Continuous Wavelets Transforms On Analysis Of A-Wave Impulse Noise, Jun Qin, Pengfei Sun
Articles
Noise induced hearing loss (NIHL) is a serious occupational related health problem worldwide. The A-wave impulse noise could cause severe hearing loss, and characteristics of such kind of impulse noise in the joint time-frequency (T-F) domain are critical for evaluation of auditory hazard level. This study focuses on the analysis of A-wave impulse noise in the T-F domain using continual wavelet transforms. Three different wavelets, referring to Morlet, Mexican hat, and Meyer wavelets, were investigated and compared based on theoretical analysis and applications to experimental generated A-wave impulse noise signals. The underlying theory of continuous wavelet transform was given and …
Eaf1p Is Required For Recruitment Of Nua4 In Targeting Tfiid To The Promoters Of The Ribosomal Protein Genes For Transcriptional Initiation In Vivo., Bhawana Uprety, Rwik Sen, Sukesh R. Bhaumik
Eaf1p Is Required For Recruitment Of Nua4 In Targeting Tfiid To The Promoters Of The Ribosomal Protein Genes For Transcriptional Initiation In Vivo., Bhawana Uprety, Rwik Sen, Sukesh R. Bhaumik
Articles
NuA4 (nucleosome acetyltransferase of H4) promotes transcriptional initiation of TFIID (a complex of TBP and TBP-associated factors [TAFs])-dependent ribosomal protein genes involved in ribosome biogenesis. However, it is not clearly understood how NuA4 regulates the transcription of ribosomal protein genes. Here, we show that NuA4 is recruited to the promoters of ribosomal protein genes, such as RPS5, RPL2B, and RPS11B, for TFIID recruitment to initiate transcription, and the recruitment of NuA4 to these promoters is impaired in the absence of its Eaf1p component. Intriguingly, impaired NuA4 recruitment in a Δeaf1 strain depletes recruitment of TFIID (a TAF-dependent form of TBP) …
Quantitative Trait Loci Underlying Seed Sugars Content In “Md96-5722” By “Spencer” Recombinant Inbred Line Population Of Soybean, Masum Akond, David A. Lightfoot, My Abdelmajid Kassem, Khalid Meksem, Shiming Liu, Stella K. Kantartzi, Nacer Bellaloui
Quantitative Trait Loci Underlying Seed Sugars Content In “Md96-5722” By “Spencer” Recombinant Inbred Line Population Of Soybean, Masum Akond, David A. Lightfoot, My Abdelmajid Kassem, Khalid Meksem, Shiming Liu, Stella K. Kantartzi, Nacer Bellaloui
Articles
Sucrose, raffinose, and stachyose are important soluble sugars in soybean [Glycine max (L.) Merr.] seeds. Seed sucrose is a desirable trait for taste and flavor. Raffinose and stachyose are undesirable in diets of monogastric animals, acting as anti-nutritional factors that cause flatulence and abdominal discomfort. Therefore, reducing raffinose and stachyose biosynthesis is considered as a key quality trait goal in soy food and feed industries. The objective of this study was to identify genomic regions containing quantitative trait loci (QTL) controlling sucrose, raffinose, and stachyose in a set of 92 F5:7 recombinant inbred lines (RILs) derived from a cross between …
Peer Victimization And Drd4 Genotype Influence Problem Behaviors In Young Children, Lisabeth Fisher Dilalla, Kyle Bersted, Sufna Gheyara John
Peer Victimization And Drd4 Genotype Influence Problem Behaviors In Young Children, Lisabeth Fisher Dilalla, Kyle Bersted, Sufna Gheyara John
Articles
Decades of research supports the presence of significant genetic influences on children’s internalizing (emotional), externalizing (acting out), and social difficulties, including victimization. Additionally, being victimized has been shown to relate to further behavioral problems. The current study assessed the nature of the gene-environment relationships between the DRD4 gene, peer victimization, and externalizing and internalizing difficulties in 6- to 10-year- old children. 174 children (56% girls; 88.6% Caucasian, 3.4% African American, 8% mixed race or Mayan) and their parents were administered victimization and problem behavior questionnaires, and DRD4 was genotyped for the children. An interaction between genes (DRD4) and environment (victimization) …
Computational Analysis And Monte Carlo Simulation Of Wave Propagation, Jun Qin
Computational Analysis And Monte Carlo Simulation Of Wave Propagation, Jun Qin
Articles
No abstract provided.
Numerical Analysis Of Bubble Dynamics In Electrohydraulic And Electromagnetic Shock Wave Lithotripsy, Jun Qin
Numerical Analysis Of Bubble Dynamics In Electrohydraulic And Electromagnetic Shock Wave Lithotripsy, Jun Qin
Articles
This study numerically investigated the bubble dynamics in electrohydraulic (EH) and electromagnetic (EM) shock wave lithotripsy (SWL). The acoustic pressure generated by a typical EH (i.e., Dornier HM-3) and EM (i.e., Siemens Modularis) lithotripters has been measured. The dynamics of cavitation bubbles in SWL has been numerically simulated using the Gilemore formulation coupled with zero-order gas diffusion. The pressure measurement results showed that both the peak positive and negative pressure of the Modularis at E4.0 are slightly higher than the corresponding values of the HM-3 at 20 kV. However, the pressure waveforms generated by an EH lithotripter is different from …
Genetic Influences On Peer And Family Relationships Across Adolescent Development: Introduction To The Special Issue, Lisabeth Fisher Dilalla, Paula Y. Mullineaux
Genetic Influences On Peer And Family Relationships Across Adolescent Development: Introduction To The Special Issue, Lisabeth Fisher Dilalla, Paula Y. Mullineaux
Articles
Nearly all aspects of human development are influenced by genetic and environmental factors, which conjointly shape development through several gene-environment interplay mechanisms. More recently, researchers have begun to examine the influence of genetic factors on peer and family relationships across the pre-adolescent and adolescent time periods. This article introduces the special issue by providing a critical overview of behavior genetic methodology and existing research demonstrating gene-environment processes operating on the link between peer and family relationships and adolescent adjustment. The overview is followed by a summary of new research studies, which use genetically informed samples to examine how peer and …
Leaving The “Big Deal” … Five Years Later, Jonathan Nabe, David Fowler
Leaving The “Big Deal” … Five Years Later, Jonathan Nabe, David Fowler
Articles
Southern Illinois University Carbondale (SIUC) and the University of Oregon each withdrew from several Big Deals with major commercial journal publishers from 2008 to 2010. Analysis of the impact of these decisions was originally conducted and reported in 2011 and 2012. This article provides updated analysis based on interlibrary loan statistics, financial savings, and impact on the collections. Results show that interlibrary loan of lost content still represents a small fraction of prior use, savings have been considerable, and the libraries have been able to address other needs in their collections because of the decision to withdraw.
Enhancing Small Cell Transmission Opportunity Through Passive Receiver Detection In Two-Tier Heterogeneous Networks, Liying Li, Guodong Zhao, Xiangwei Zhou
Enhancing Small Cell Transmission Opportunity Through Passive Receiver Detection In Two-Tier Heterogeneous Networks, Liying Li, Guodong Zhao, Xiangwei Zhou
Articles
In this paper, we investigate how to embed small cells into a macro cell to enhance the performance of two-tier heterogeneous networks. Conventionally, overlay and underlay schemes are adopted by small cells, where the former enables a small cell to use the macro cell idle bands with transmitter detection, while the latter enables a small cell to use the macro cell busy bands with a certain access probability. To enhance the performance of small cells, we propose to exploit more busy band opportunities for small cells through passive receiver detection, i.e., identifying the location of an active macro user that …
Distinguishing Gasoline Engine Oils Of Different Viscosities Using Terahertz Time- Domain Spectroscopy, Ali M. Abdul-Munaim, Marco Reuter, Martin Koch, Dennis G. Watson
Distinguishing Gasoline Engine Oils Of Different Viscosities Using Terahertz Time- Domain Spectroscopy, Ali M. Abdul-Munaim, Marco Reuter, Martin Koch, Dennis G. Watson
Articles
Terahertz-time-domain spectroscopy (THz-TDS) in the range of 0.5–2.0 THz was evaluated for distinguishing among gasoline engine oils of three different grades (SAE 5W-20, 10W-40, and 20W-50) from the same manufacturer. Absorption coefficient showed limited potential and only distinguished (p < 0.05) the 20W-50 grade from the other two grades in the 1.7-2.0 THz range. Refractive index data demonstrated relatively flat and consistently spaced curves for the three oil grades. ANOVA results confirmed a highly significant difference (p < 0.0001) in refractive index among each of the three oils across the 0.5 - 2.0 THz range. Linear regression was applied to refractive index data at 0.25 THz intervals from 0.5 – 2.0 THz to predict kinematic viscosity. All seven linear regression models, intercepts, and refractive index coefficients were highly significant (p < 0.0001). All models had a similar fit with R2 ranging from 0.9773 to 0.9827 and RMSE ranging from 6.33 to 7.75.The refractive indices at 1.25 THz produced the best fit. The refractive indices of these oil samples were promising for identification and distinction of oil grades.
Simultaneous Extraction, Optimization, And Analysis Of Flavonoids And Polyphenols From Peach And Pumpkin Extracts Using A Tlc-Densitometric Method, Ammar Altemimi, Dennis G. Watson, Mary Kinsel, David A. Lightfoot
Simultaneous Extraction, Optimization, And Analysis Of Flavonoids And Polyphenols From Peach And Pumpkin Extracts Using A Tlc-Densitometric Method, Ammar Altemimi, Dennis G. Watson, Mary Kinsel, David A. Lightfoot
Articles
Background: The use of medicinal plants has been reported throughout human history. In the fight against illnesses, medicinal plants represent the primary health care system for 60 % of the world’s population. Flavonoids are polyphenolic compounds with active anti-microbial properties; they are produced in plants as pigments. Quercetin, myricetin, and rutin are among the most well-known and prevalent flavonoids in plants, with an antioxidant activity capable of decreasing the oxidation of low density lipoproteins [LDLs]. To date, this research is the first of its kind to employ a coupled thin-layer chromatography (TLC) and a densitometric quantification method with a Box-Behnken …
Some Pp Modifiers Of Np Block Relative Readings In Superlatives, Heidi Harley, Jeffrey Punske
Some Pp Modifiers Of Np Block Relative Readings In Superlatives, Heidi Harley, Jeffrey Punske
Articles
No abstract provided.
Loss Of Foxm1 Results In Reduced Somatotrope Cell Number During Mouse Embryogenesis., Michael J Calderon, Adam G Ploegman, Brock Bailey, Deborah O Jung, Amy M Navratil, Buffy S Ellsworth
Loss Of Foxm1 Results In Reduced Somatotrope Cell Number During Mouse Embryogenesis., Michael J Calderon, Adam G Ploegman, Brock Bailey, Deborah O Jung, Amy M Navratil, Buffy S Ellsworth
Articles
FOXM1, a member of the forkhead box transcription factor family, plays a key role in cell cycling progression by regulating the expression of critical G1/S and G2/M phase transition genes. In vivo studies reveal that Foxm1 null mice have a 91% lethality rate at e18.5 due to significant cardiovascular and hepatic hypoplasia. Thus, FOXM1 has emerged as a key protein regulating mitotic division and cell proliferation necessary for embryogenesis. In the current study, we assess the requirement for Foxm1 in the developing pituitary gland. We find that Foxm1 is expressed in the pituitary at embryonic days 10.5-e18.5 and localizes with …
Employing Response Surface Methodology For The Optimization Of Ultrasound Assisted Extraction Of Lutein And Β-Carotene From Spinach, David A. Lightfoot, Ammar Altemimi, Mary Kinsel, Dennis G. Watson
Employing Response Surface Methodology For The Optimization Of Ultrasound Assisted Extraction Of Lutein And Β-Carotene From Spinach, David A. Lightfoot, Ammar Altemimi, Mary Kinsel, Dennis G. Watson
Articles
Abstract: The extraction of lutein and β-carotene from spinach (Spinacia oleracea L.) leaves is important to the dietary supplement industry. A Box-Behnken design and response surface methodology (RSM) were used to investigate the effect of process variables on the ultrasound-assisted extraction (UAE) of lutein and β-carotene from spinach. Three independent variables, extraction temperature (°C), extraction power (%) and extraction time (min) were studied. Thin-layer chromatography (TLC) followed by UV visualization and densitometry was used as a simple and rapid method for both identification and quantification of lutein and β-carotene during UAE. Methanol extracts of leaves from spinach and authentic …
Low Temperature Electrochemical Deposition Of Highly Active Elements, Daniel Falola, Ian Suni
Low Temperature Electrochemical Deposition Of Highly Active Elements, Daniel Falola, Ian Suni
Articles
Electrochemical methods are attractive for thin film deposition due to their simplicity, conformal and high rate deposition, the ability to easily make multilayers of different composition, ease of scale-up to large surface areas, and applicability to wide variety of different shapes and surface geometries. However, many elements from periodic table of commercial importance are too active to be electrodeposited from aqueous solution. Recent advances are briefly reviewed for room temperature methods for electrochemical deposition, including electrodeposition from ionic liquids, electrodeposition from organic solvents, combined electrodeposition and precipitation on liquid metal cathodes, and galvanic deposition. Recent studies of electrodeposition from ionic …
Energy-Efficient Spectrum Sensing For Cognitive Radio Enabled Remote State Estimation Over Wireless Channels, Xianghui Cao, Xiangwei Zhou, Lu Liu, Yu Cheng
Energy-Efficient Spectrum Sensing For Cognitive Radio Enabled Remote State Estimation Over Wireless Channels, Xianghui Cao, Xiangwei Zhou, Lu Liu, Yu Cheng
Articles
The performance of remote estimation over wireless channels is strongly affected by sensor data losses due to interference. Although the impact of interference can be alleviated by applying cognitive radio technique which features in spectrum sensing and transmitting data only on clear channels, the introduction of spectrum sensing incurs extra energy expenditure. In this paper, we investigate the problem of energy-efficient spectrum sensing for remotely estimating the state of a general linear dynamic system, and formulate an optimization problem which minimizes the total sensor energy consumption while guaranteeing a desired level of estimation performance. We model the problem as a …
Data Acquisition And Digital Instrumentation Engineering Modelling For Intelligent Learning And Recognition, Jun Qin, Lin Xu
Data Acquisition And Digital Instrumentation Engineering Modelling For Intelligent Learning And Recognition, Jun Qin, Lin Xu
Articles
In data acquisition and digital instrumentation fields, it is essential to understand the learning and recognition to acquire data and information of objects to be studied. In recent years, engineering modelling and simulation contribute greatly to the understanding of intelligent learning and recognition problems. The ability to learn is one of the central features of intelligence, which makes it an important concern for both cognitive psychology and artificial intelligence. In this paper, definitions and modelling aspects of learning are discussed. Fundamentals of learning and recognition and their applications are investigated and described. Illustrations are given to demonstrate the increasing applications …
Data Acquisition And Digital Instrumentation Engineering Modelling For Intelligent Learning And Recognition, Jun Qin, Lin Xu
Data Acquisition And Digital Instrumentation Engineering Modelling For Intelligent Learning And Recognition, Jun Qin, Lin Xu
Articles
In data acquisition and digital instrumentation fields, it is essential to understand the learning and recognition to acquire data and information of objects to be studied. In recent years, engineering modelling and simulation contribute greatly to the understanding of intelligent learning and recognition problems. The ability to learn is one of the central features of intelligence, which makes it an important concern for both cognitive psychology and artificial intelligence. In this paper, definitions and modelling aspects of learning are discussed. Fundamentals of learning and recognition and their applications are investigated and described. Illustrations are given to demonstrate the increasing applications …
Archives And Non-Humanities Students: Teaching With Primary Sources Beyond Document Analysis, Matthew J. Gorzalski
Archives And Non-Humanities Students: Teaching With Primary Sources Beyond Document Analysis, Matthew J. Gorzalski
Articles
No abstract provided.
Amperometric Bioelectronic Tongue For Glucose Determination, Ian Suni
Amperometric Bioelectronic Tongue For Glucose Determination, Ian Suni
Articles
An amperometric Bioelectronic Tongue is reported for glucose determination that contains eight sensor electrodes constructed using different metal electrodes (Pt, Au), oxidoreductase enzymes (glucose oxidase, ascorbate oxidase, uricase), and membrane coatings (Nafion, chitosan). The response to varying concentrations of glucose, ascorbic acid, uric acid, and acetaminophen was tested for two models, concentration determination by current density measurements at individual electrodes and concentration determination by a linear regression model for the entire electrode array. The reduced chi-squared for the full array model was found to be about one order of magnitude lower than that for the individualelectrode model. Discrimination of glucose …
Speed Error Mitigation For A Dsp-Based Resolver-To-Digital Converter Using Auto-Tuning Filters, Nezar Abou Qamar, Constantine J. Hatziadoniu, Haibo Wang
Speed Error Mitigation For A Dsp-Based Resolver-To-Digital Converter Using Auto-Tuning Filters, Nezar Abou Qamar, Constantine J. Hatziadoniu, Haibo Wang
Articles
Modern resolver-to-digital converters (RDC) are typically implemented using DSP techniques to reduce hardware footprint and enhanced system accuracy. However, in such implementations, both resolver sensor and ADC channel unbalances introduce significant errors particularly in the speed output of the tracking loop. The frequency spectrum of the output error is variable depending on the resolver mechanical velocity. This paper presents the design of an auto-tuning output filter based on the interpolation of pre-computed filters for a DSP-based RDC with a type-II tracking loop. A fourth-order peak and a second-order high pass filter are designed and tested for an experimental RDC. The …
Alternative Splicing Of Mef2c Pre-Mrna Controls Its Activity In Normal Myogenesis And Promotes Tumorigenicity In Rhabdomyosarcoma Cells., Meiling Zhang, Bo Zhu, Judith Davie
Alternative Splicing Of Mef2c Pre-Mrna Controls Its Activity In Normal Myogenesis And Promotes Tumorigenicity In Rhabdomyosarcoma Cells., Meiling Zhang, Bo Zhu, Judith Davie
Articles
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Many cellular disruptions contribute to the progression of this pediatric cancer, including aberrant alternative splicing. The MEF2 family of transcription factors regulates many developmental programs, including myogenesis. MEF2 gene transcripts are subject to alternate splicing to generate protein isoforms with divergent functions. We found that MEF2Cα1 was the ubiquitously expressed isoform that exhibited no myogenic activity and that MEF2Cα2, the muscle-specific MEF2C isoform, was required for efficient differentiation. We showed that exon α in MEF2C was aberrantly alternatively spliced in RMS cells, with the ratio of α2/α1 highly down-regulated …