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Articles 1 - 12 of 12
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Transitioning Cell Culture Cure Labs From Campus To Online: Novel Strategies For A Novel Time, Jaime L. Sabel, Kendra Wright, Jacob J. Adler, Gary Bates, La Shall Bates, Sumali Pandey, Amanda M. Simons, Sarah J. Swerdlow, Nathan S. Reyna, Lori Hensley
Transitioning Cell Culture Cure Labs From Campus To Online: Novel Strategies For A Novel Time, Jaime L. Sabel, Kendra Wright, Jacob J. Adler, Gary Bates, La Shall Bates, Sumali Pandey, Amanda M. Simons, Sarah J. Swerdlow, Nathan S. Reyna, Lori Hensley
Articles
Course-based undergraduate research experiences (CUREs) provide a way for students to gain research experience in a classroom setting. Few examples of cell culture CUREs or online CUREs exist in the literature. The Cell Biology Education Consortium (CBEC) provides a network and resources for instructors working to incorporate cell-culture based research into the classroom. In this article, we provide examples from six instructors from the CBEC network on how they structure their cell-culture CUREs and how they transitioned the labs to online in the spring semester of 2020. We intend for these examples to provide instructors with ideas for strategies to …
Gene Expression And Data Analysis Pipeline Using Cancer Bioportal In The Classroom, Chassidy N. Barnes, Blake P. Johnson, Stefanie W. Leacock, Ruben M. Ceballos, Lori L. Hensley, Nathan S. Reyna
Gene Expression And Data Analysis Pipeline Using Cancer Bioportal In The Classroom, Chassidy N. Barnes, Blake P. Johnson, Stefanie W. Leacock, Ruben M. Ceballos, Lori L. Hensley, Nathan S. Reyna
Articles
At institutions with an emphasis on authentic research experiences as an integral part of the biology curriculum, COVID created a huge challenge for course instructors whose learning objectives were designed for such experiences. Moving such laboratory experiences online when remote learning became necessary has resulted in a new model for CUREs that utilizes free online databases to provide not only a novel research experience for students, but also the opportunity to engage in big data analysis. Cancer BioPortal (cBioPortal) is an open-access collective cancer research resource for storing and exploring clinical, genomic, proteomic, and transcriptomic data. cBioPortal eliminates the computational …
Novel Role For The Golgi Membrane Protein Tmem165 In Control Of Migration And Invasion For Breast Carcinoma, Pavitra Murali, Blake P. Johnson, Zhongpeng Lu, Leslie Climer, Danielle A. Scott, Francois Foulquier, Gabriela Oprea-Ilies, Vladimir Lupashin, Richard R. Drake, Karen L. Abbott
Novel Role For The Golgi Membrane Protein Tmem165 In Control Of Migration And Invasion For Breast Carcinoma, Pavitra Murali, Blake P. Johnson, Zhongpeng Lu, Leslie Climer, Danielle A. Scott, Francois Foulquier, Gabriela Oprea-Ilies, Vladimir Lupashin, Richard R. Drake, Karen L. Abbott
Articles
The TMEM165 gene encodes for a multiple pass membrane protein localized in the Golgi that has been linked to congenital disorders of glycosylation. The TMEM165 protein is a putative ion transporter that regulates H+/Ca++/Mn++ homeostasis and pH in the Golgi. Previously, we identified TMEM165 as a potential biomarker for breast carcinoma in a glycoproteomic study using late stage invasive ductal carcinoma tissues with patient-matched adjacent normal tissues. The TMEM165 protein was not detected in non-malignant matched breast tissues and was detected in invasive ductal breast carcinoma tissues by mass spectrometry. Our hypothesis is that the TMEM165 protein confers a growth …
Genomic Diversity Of Bacteriophages Infecting Microbacterium Spp, Deborah Jacobs-Sera, Nathan S. Reyna, Lawrence A. Abad, Richard M. Alvey, Kirk R. Anders, Haley G. Aull, Suparna S. Bhalla, Lawrence S. Blumer, David W. Bollivar, J. Alfred Bonilla, Kristen A. Butela, Roy J. Coomans, Steven G. Cresawn, Tom D'Elia, Arturo Diaz, Ashley M. Divens, Nicholas P. Edgington, Gregory D. Frederick, Maria D. Gainey, Rebecca A. Garlena, Kenneth W. Grant, Susan M.R. Gurney, Heather L. Hendrickson, Lee E. Hughes, Margaret A. Kenna, Karen K. Klyczek, Hari Kotturi, Travis N. Mavrich, Angela L. Mckinney, Evan C. Merkhofer, Jordan Moberg Parker, Sally D. Molloy, Denise L. Monti, Dana A. Pape-Zambito
Genomic Diversity Of Bacteriophages Infecting Microbacterium Spp, Deborah Jacobs-Sera, Nathan S. Reyna, Lawrence A. Abad, Richard M. Alvey, Kirk R. Anders, Haley G. Aull, Suparna S. Bhalla, Lawrence S. Blumer, David W. Bollivar, J. Alfred Bonilla, Kristen A. Butela, Roy J. Coomans, Steven G. Cresawn, Tom D'Elia, Arturo Diaz, Ashley M. Divens, Nicholas P. Edgington, Gregory D. Frederick, Maria D. Gainey, Rebecca A. Garlena, Kenneth W. Grant, Susan M.R. Gurney, Heather L. Hendrickson, Lee E. Hughes, Margaret A. Kenna, Karen K. Klyczek, Hari Kotturi, Travis N. Mavrich, Angela L. Mckinney, Evan C. Merkhofer, Jordan Moberg Parker, Sally D. Molloy, Denise L. Monti, Dana A. Pape-Zambito
Articles
The bacteriophage population is vast, dynamic, old, and genetically diverse. The genomics of phages that infect bacterial hosts in the phylum Actinobacteria show them to not only be diverse but also pervasively mosaic, and replete with genes of unknown function. To further explore this broad group of bacteriophages, we describe here the isolation and genomic characterization of 116 phages that infect Microbacterium spp. Most of the phages are lytic, and can be grouped into twelve clusters according to their overall relatedness; seven of the phages are singletons with no close relatives. Genome sizes vary from 17.3 kbp to 97.7 kbp, …
Mass Spectrometry As A Tool To Enhance “-Omics” Education, Michael J. Wolyniak, Nathan S. Reyna, Ruth Plymale, Welkin H. Pope, Daniel E. Westholm
Mass Spectrometry As A Tool To Enhance “-Omics” Education, Michael J. Wolyniak, Nathan S. Reyna, Ruth Plymale, Welkin H. Pope, Daniel E. Westholm
Articles
The rise of "-omics" related technologies makes it essential for students to have experience working with large bioinformatics data sets. Although”-omic” datasets are complex and abstract, effective instruction can be improved when students see the direct connections between the data on a computer screen and the results of "wet lab" experimentation. Here we describe the use of protein mass spectrometry as a means for students to gain experience in connecting bioinformatic data with work done at the lab bench. Course-based Research Experiences (CREs) based on these techniques are accessible to institutions of all types as a result of rapidly declining …
Genome Sequences Of Four Cluster P Mycobacteriophages, Erin L. Doyle, Christy L. Fillman, Nathan S. Reyna, Ruth C. Plymale, Deborah M. Tobiason, Daniel E. Westholm, Jonathan L. Askins, Brittany P. Backus, Ashlynn C. Baker, Harrison S. Ballard, Paul J. Bisesi, Logan Bond, Deanna Byrnes, Hannah Carlstedt, Kinnon S. Dodson, Megan J. Fallert, Kyla J. Foster, Daniel N. Games, Tristan R. Grams, Nancy A. Guild, Autumn Hurd, Nicholas Iwata, Cassidy R. Kepler, Lucinda R. Krenzke, Kelly Luekens, Jackie Lewis, Cali Mcentee, Justin C. Mcgee, Noah Nalley, Jade Prochaska, Reid G. Rogers, Jessica B. Schipper, Kelsey Snyder
Genome Sequences Of Four Cluster P Mycobacteriophages, Erin L. Doyle, Christy L. Fillman, Nathan S. Reyna, Ruth C. Plymale, Deborah M. Tobiason, Daniel E. Westholm, Jonathan L. Askins, Brittany P. Backus, Ashlynn C. Baker, Harrison S. Ballard, Paul J. Bisesi, Logan Bond, Deanna Byrnes, Hannah Carlstedt, Kinnon S. Dodson, Megan J. Fallert, Kyla J. Foster, Daniel N. Games, Tristan R. Grams, Nancy A. Guild, Autumn Hurd, Nicholas Iwata, Cassidy R. Kepler, Lucinda R. Krenzke, Kelly Luekens, Jackie Lewis, Cali Mcentee, Justin C. Mcgee, Noah Nalley, Jade Prochaska, Reid G. Rogers, Jessica B. Schipper, Kelsey Snyder
Articles
Four bacteriophages infecting Mycobacterium smegmatis mc2155 (three belonging to subcluster P1 and one belonging to subcluster P2) were isolated from soil and sequenced. All four phages are similar in the left arm of their genomes, but the P2 phage differs in the right arm. All four genomes contain features of temperate phages.
Comparative Genomics Of Cluster O Mycobacteriophages, Steven G. Cresawn, Nathan S. Reyna, Ruth Plymale, Welkin H. Pope, Deborah Jacobs-Sera, Charles A. Bowman, Daniel A. Russell, Rebekah M. Dedrick, Tamarah Adair, Kirk R. Anders, Sarah Ball, David Bollivar, Caroline Breitenberger, Sandra H. Burnett, Kristen Butela, Deanna Byrnes, Sarah Carzo, Kathleen A. Cornely, Trevor Cross, Richard L. Daniels, David Dunbar, Ann M. Findley, Chris R. Gissendanner, Urszula P. Golebiewska, Grant A. Hartzog, J. Robert Hatherill, Lee E. Hughes, Chernoh S. Jalloh, Carla De Los Santos, Kevin Ekanem, Sphindile L. Khambule, Rodney A. King, Christina King-Smith, Karen Klyczek, Greg P. Krukonis
Comparative Genomics Of Cluster O Mycobacteriophages, Steven G. Cresawn, Nathan S. Reyna, Ruth Plymale, Welkin H. Pope, Deborah Jacobs-Sera, Charles A. Bowman, Daniel A. Russell, Rebekah M. Dedrick, Tamarah Adair, Kirk R. Anders, Sarah Ball, David Bollivar, Caroline Breitenberger, Sandra H. Burnett, Kristen Butela, Deanna Byrnes, Sarah Carzo, Kathleen A. Cornely, Trevor Cross, Richard L. Daniels, David Dunbar, Ann M. Findley, Chris R. Gissendanner, Urszula P. Golebiewska, Grant A. Hartzog, J. Robert Hatherill, Lee E. Hughes, Chernoh S. Jalloh, Carla De Los Santos, Kevin Ekanem, Sphindile L. Khambule, Rodney A. King, Christina King-Smith, Karen Klyczek, Greg P. Krukonis
Articles
Mycobacteriophages - viruses of mycobacterial hosts - are genetically diverse but morphologically are all classified in the Caudovirales with double-stranded DNA and tails. We describe here a group of five closely related mycobacteriophages - Corndog, Catdawg, Dylan, Firecracker, and YungJamal - designated as Cluster O with long flexible tails but with unusual prolate capsids. Proteomic analysis of phage Corndog particles, Catdawg particles, and Corndog-infected cells confirms expression of half of the predicted gene products and indicates a non-canonical mechanism for translation of the Corndog tape measure protein. Bioinformatic analysis identifies 8-9 strongly predicted SigA promoters and all five Cluster O …
Matching Variables For Research Involving Youth With Down Syndrome: Leiter-R Versus Ppvt-4, B. Allyson Phillips
Matching Variables For Research Involving Youth With Down Syndrome: Leiter-R Versus Ppvt-4, B. Allyson Phillips
Articles
Much of what is known about the cognitive profile of Down syndrome (DS) is based on using either receptive vocabulary (e.g., PPTV-4) or nonverbal ability (e.g., Leiter-R) as a baseline to represent cognitive developmental level. In the present study, we examined the relation between these two measures in youth with DS, with non-DS intellectual disability (ID) and with typical development (TD). We also examined the degree to which these two measures produce similar results when used as a group matching variable. In a cross-sectional developmental trajectory analysis, we found that the relation between PPVT-4 and Leiter-R was largely similar across …
Four Week Lumbopelvic-Hip Complex Intervention Program And Its Effects On Tuck Jump Assessment In Active Youth, Gretchen D. Oliver, Terry Dewitt
Four Week Lumbopelvic-Hip Complex Intervention Program And Its Effects On Tuck Jump Assessment In Active Youth, Gretchen D. Oliver, Terry Dewitt
Articles
Injury in youth physical activity has become a major concern with the rising rate of participation. Lumbopelvic-hip complex (LPHC) stability, also known as core stability, has been found to contribute to proper force dissipation and ultimately more effective mechanics. Therefore, the purpose of this study was to examine the effects of a LPHC neuromuscular strengthening program on at-risk youth using the Tuck Jump Assessment. Forty-five youth grades 6, 7, and 8 participated in the Tuck Jump Assessment. Then those participants who scores were indicative of 'at risk' were enrolled in a four-week LPHC intervention program. Those participants whose sores did …
Emergent Fungal Entomopathogen Does Not Alter Density Dependence In A Viral Competitor, Andrew M. Liebhold, Ruth Plymale, Joseph S. Elkinton, Ann E. Hajek
Emergent Fungal Entomopathogen Does Not Alter Density Dependence In A Viral Competitor, Andrew M. Liebhold, Ruth Plymale, Joseph S. Elkinton, Ann E. Hajek
Articles
Population cycles in forest Lepidoptera often result from recurring density-dependent epizootics of entomopathogens. While these systems are typically dominated by a single pathogen species, insects are often infected by multiple pathogens, yet little is known how pathogens interact to affect host dynamics. The apparent invasion of northeastern North America by the fungal entomopathogen Entomophaga maimaiga some time prior to 1989 provides a unique opportunity to evaluate such interactions. Prior to the arrival of E. maimaga, the oscillatory dynamics of host gypsy moth, Lymantria dispar, populations were apparently driven by epizootics of a nucleopolyhedrovirus. Subsequent to its emergence, E. …
Variability In Azygospore Production Among Entomophaga Maimaiga Isolates, Ann E. Hajek, Ruth C. Plymale
Variability In Azygospore Production Among Entomophaga Maimaiga Isolates, Ann E. Hajek, Ruth C. Plymale
Articles
This study describes in vitro and in vivo azygospore production by nine isolates of Entomophaga maimaiga, a fungal pathogen of the gypsy moth, Lymantria dispar. The three E. maimaiga isolates that consistently produced azygospores in vitro were also strong producers of azygospores in vivo. However, two additional isolates that were strong azygospore producers in vivo did not produce azygospores in vitro. Isolates that produced azygospores in vitro produced both conidia and azygospores more frequently in vivo than isolates not producing azygospores in vitro. In vitro azygospore production varied over time as well as by isolate. After >2 years of cold …
Pandemic Bibliography, S. Ray Granade
Pandemic Bibliography, S. Ray Granade
Articles
A bibliography of pandemic disease compiled for a class.