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Comparing The Evidence From Observational Studies And Randomized Controlled Trials For Nonskeletal Health Effects Of Vitamin D, William B. Grant, Barbara J. Boucher, Fatme Al Anouti, Stefan Pilz Sep 2022

Comparing The Evidence From Observational Studies And Randomized Controlled Trials For Nonskeletal Health Effects Of Vitamin D, William B. Grant, Barbara J. Boucher, Fatme Al Anouti, Stefan Pilz

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Although observational studies of health outcomes generally suggest beneficial effects with, or following, higher serum 25-hydroxyvitamin D [25(OH)D] concentrations, randomized controlled trials (RCTs) have generally not supported those findings. Here we review results from observational studies and RCTs regarding how vitamin D status affects several nonskeletal health outcomes, including Alzheimer's disease and dementia, autoimmune diseases, cancers, cardiovascular disease, COVID-19, major depressive disorder, type 2 diabetes, arterial hypertension, all-cause mortality, respiratory tract infections, and pregnancy outcomes. We also consider relevant findings from ecological, Mendelian randomization, and mechanistic studies. Although clear discrepancies exist between findings of observational studies and RCTs on vitamin …


Epidemiology Of Pre-Pregnancy Body Mass Index (Bmi) Among Mothers In Abu Dhabi, The United Arab Emirates, Zainab Taha, Ahmed Ali Hassan, Dimitrios Papandreou Sep 2022

Epidemiology Of Pre-Pregnancy Body Mass Index (Bmi) Among Mothers In Abu Dhabi, The United Arab Emirates, Zainab Taha, Ahmed Ali Hassan, Dimitrios Papandreou

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Pre-pregnancy obesity is a risk factor for several health problems such as gestational diabetes, preeclampsia, labor induction, postpartum hemorrhage, and neonatal hypoglycemia. Being underweight is a risk factor for fetal growth restriction. Despite the negative impact of abnormal pre-pregnancy body mass index (BMI) (over and underweight) on pregnancy outcomes, a limited amount of studies has been conducted on the prevalence of pre-pregnancy over and underweight and associated factors in the United Arab Emirates (UAE). Thus, the aim of this study was to investigate the prevalence and factors associated with underweight, overweight, and obesity among mothers with children under the age …


Symptoms Of Paranoia Experienced By Students Of Pakistani Heritage In England: The Role Of Explicit And Implicit Identities And Perceived Discrimination, Anam Elahi, Jason C. Mcintyre, Justin Thomas, Louise Abernethy, Richard P. Bentall, Ross G. White Sep 2022

Symptoms Of Paranoia Experienced By Students Of Pakistani Heritage In England: The Role Of Explicit And Implicit Identities And Perceived Discrimination, Anam Elahi, Jason C. Mcintyre, Justin Thomas, Louise Abernethy, Richard P. Bentall, Ross G. White

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ABSTRACT: Individuals belonging to ethnic minority groups are less likely to experience symptoms of psychosis, such as paranoia, if they live in areas with high proportions of people from the same ethnic background. This effect may be due to processes associated with group belonging (social identification). We examined whether the relationship between perceived discrimination and paranoia was moderated by explicit and implicit Pakistani/English identification among students of Pakistani heritage (N = 119). Participants completed measures of explicit and implicit Pakistani and English identity, a measure of perceived discrimination, and a measure of paranoia. Perceived discrimination was the strongest predictor of …


Determinants Of Delayed Initiation Of Breastfeeding: A Cross-Sectional Multicenter Study In Abu Dhabi, The United Arab Emirates, Zainab Taha, Aysha Ibrahim Al Dhaheri, Ludmilla Wikkeling-Scott, Ahmed Ali Hassan, Dimitrios Papandreou Jul 2022

Determinants Of Delayed Initiation Of Breastfeeding: A Cross-Sectional Multicenter Study In Abu Dhabi, The United Arab Emirates, Zainab Taha, Aysha Ibrahim Al Dhaheri, Ludmilla Wikkeling-Scott, Ahmed Ali Hassan, Dimitrios Papandreou

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One of the best practices to reduce the risk of infant morbidity and mortality is the early initiation of breastfeeding, specifically within the first hour of birth, as the World Health Organization (WHO) recommends. Limited data exist on breastfeeding initiation and its related factors in the United Arab Emirates (U.A.E.). Therefore, the purpose of this research study was to evaluate and analyze the determinant factors associated with delayed initiation of breastfeeding among mothers with children aged <2 years old in a cross-sectional multicenter setting in Abu Dhabi, U.A.E. Seven governmental community and healthcare centers participated in the study from diverse geographic areas of Abu Dhabi. A trained female research assistant collected information from mothers with young children attending the centers. All participants were informed in detail about the purpose of the study and signed a written consent form. A total of 1610 mother-child pairs were included in the study. The mean (standard deviation) of maternal age and children's age was 30.1 (5.1) years and 8.1 (5.9) months, respectively. Six hundred and four (604) (37.5%) reported delayed initiation of breastfeeding. Factors associated with delayed breastfeeding initiation were being of non-Arab nationality (adjusted odds ratio (A.O.R.) 1.30, 95% confidence interval (CI) 1.03, 1.63), caesarean section (AOR 2.85, 95% CI 2.26, 3.58), non-rooming-in (AOR 2.82, 95% CI 1.53, 5.21), first birth order (AOR 1.34, 95% CI 1.07, 1.69), and mothers with low-birth-weight children (AOR 3.30, 95% CI 2.18, 4.99) as was analyzed by multivariate logistic regression analysis. In conclusion, approximately four out of ten mothers delayed initiation of breastfeeding for more than one hour after delivery. The results of this study call for urgent policy changes to improve the early initiation rates of breastfeeding mothers in the U.A.E.


A Narrative Review Of The Evidence For Variations In Serum 25-Hydroxyvitamin D Concentration Thresholds For Optimal Health, William B. Grant, Fatme Al Anouti, Barbara J. Boucher, Erdinç Dursun, Duygu Gezen-Ak, Edward B. Jude, Tatiana Karonova, Pawel Pludowski Feb 2022

A Narrative Review Of The Evidence For Variations In Serum 25-Hydroxyvitamin D Concentration Thresholds For Optimal Health, William B. Grant, Fatme Al Anouti, Barbara J. Boucher, Erdinç Dursun, Duygu Gezen-Ak, Edward B. Jude, Tatiana Karonova, Pawel Pludowski

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Vitamin D3 has many important health benefits. Unfortunately, these benefits are not widely known among health care personnel and the general public. As a result, most of the world’s population has serum 25-hydroxyvitamin D (25(OH)D) concentrations far below optimal values. This narrative review examines the evidence for the major causes of death including cardiovascular disease, hypertension, cancer, type 2 diabetes mellitus, and COVID-19 with regard to sub-optimal 25(OH)D concentrations. Evidence for the beneficial effects comes from a variety of approaches including ecological and observational studies, studies of mechanisms, and Mendelian randomization studies. Although randomized controlled trials (RCTs) are generally considered …