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Probing The Early Stages Of Polyglutamine Aggregation With Computational Methods, Andreas Vitalis
Probing The Early Stages Of Polyglutamine Aggregation With Computational Methods, Andreas Vitalis
All Theses and Dissertations (ETDs)
Exonic CAG repeat diseases are a class of neurodegenerative age-of-onset diseases caused by an unstable trinucleotide expansion in a coding region of a gene. The most prominent example is Huntington's disease: HD) whose symptoms are characterized by loss of motor control and cognitive deficits. For all nine of the known CAG repeat diseases, pathology is ascribed to the mutant proteins which carry expanded stretches of glutamine residues: polyglutamine). The length of the polyglutamine segment is inversely correlated with the disease age-of-onset. Protein aggregates are routinely found in postmortem tissue samples of brains of HD patients. These findings suggest a prominent …
Statistical Aggregation: Theory And Applications, Ruibin Xi
Statistical Aggregation: Theory And Applications, Ruibin Xi
All Theses and Dissertations (ETDs)
Due to their size and complexity, massive data sets bring many computational challenges for statistical analysis, such as overcoming the memory limitation and improving computational efficiency of traditional statistical methods. In the dissertation, I propose the statistical aggregation strategy to conquer such challenges posed by massive data sets. Statistical aggregation partitions the entire data set into smaller subsets, compresses each subset into certain low-dimensional summary statistics and aggregates the summary statistics to approximate the desired computation based on the entire data. Results from statistical aggregation are required to be asymptotically equivalent. Statistical aggregation processes the entire data set part by …
Aggregation & Localization Of A Disease-Associated Prion Protein (Prp) Mutant, Andrea Rhonda Medrano
Aggregation & Localization Of A Disease-Associated Prion Protein (Prp) Mutant, Andrea Rhonda Medrano
All Theses and Dissertations (ETDs)
ABSTRACT OF THE DISSERTATION Aggregation & Localization of a Disease-Associated Prion Protein: PrP) Mutant by Andrea Rhonda Zaragoza Medrano Doctor of Philosophy in Biology and Biomedical Sciences: Genetics) Washington University in St. Louis, 2009 Professor David A. Harris, Chairperson Prion protein: PrP) is a GPI-anchored sialoglycoprotein involved in the pathogenesis of infectious and inherited forms of transmissible spongiform encephalopathies: TSEs). A nine-octapeptide insertional mutation in the prion protein: PrP) causes a fatal neurodegenerative disorder in both humans and transgenic mice. To determine the precise cellular localization of this mutant PrP: designated PG14), we have generated transgenic mice expressing PG14-EGFP, a …