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All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Theses/Dissertations

Mass spectrometry

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Investigating Mitochondrial Influence On The Rate Of Anaerobic Glycolysis In An In Vitro Model, Mackenzie Jenna' Taylor Aug 2023

Investigating Mitochondrial Influence On The Rate Of Anaerobic Glycolysis In An In Vitro Model, Mackenzie Jenna' Taylor

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The rate at which the muscle acidifies after an animal is harvested has a profound effect on the quality of the resulting pork. When acidification increases gradually, desirable pork quality characteristics are developed. In contrast, rapid acidification deteriorates pork quality, exemplified by the pale, soft, and exudative (PSE) pork defect. The rate of acidification is determined by the rate of anaerobic metabolism in postmortem muscle. Yet the processes controlling postmortem anaerobic metabolism are not well understood. Recent research suggests that mitochondria, the powerhouse of the cell, may influence this process by competing for substrate (pyruvate) with anaerobic metabolism, thereby reducing …


A Dynamic State Metabolic Journey: From Mass Spectrometry To Network Analysis Via Estimation Of Kinetic Parameters, Arockia Ranjitha Dhanasekaran Dec 2011

A Dynamic State Metabolic Journey: From Mass Spectrometry To Network Analysis Via Estimation Of Kinetic Parameters, Arockia Ranjitha Dhanasekaran

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The term "metabolism" refers to the chemical processes occurring in a living organism to convert the food consumed into the energy needed to maintain a living state. Metabolism consists of two states, namely, a dynamic state and a steady state. In the dynamic state, the rate of chemical conversion of a substance is proportional to the amount of substance available, whereas in the steady state this rate is constant and independent of the amount of substance present (Chapter 4 Figure 1). Like all other fields of engineering, metabolic engineering involves the analysis and synthesis of metabolism. Molecular biological tools for …