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The Role Of Spinal Serotonergic Receptors 5-Ht1a And 5-Ht3 In Stress-Induced Urinary Bladder Hypersensitivity, Chelsea L. Crawford
The Role Of Spinal Serotonergic Receptors 5-Ht1a And 5-Ht3 In Stress-Induced Urinary Bladder Hypersensitivity, Chelsea L. Crawford
All ETDs from UAB
Disorders in which pain originates from the urinary bladder such as interstitial cystitis (IC) are steadily increasing in prevalence. A common finding among patients with IC is the comorbidity with stress or anxiety disorders. In rats, footshock stress alone is sufficient to elicit bladder hypersensitivity. Serotonin (5-hydroxytryptamine; 5-HT) has been established as a mediator in anxiety and pain separately, but little is known about the role of 5-HT in stress-induced visceral hypersensitivity. The current set of studies addresses three main concerns: (1) the impact of spinal 5-HT1A and 5-HT3 receptor blockade with WAY-100635 (10 µg) and ondansetron (10 µg), respectively, …
Stress And Myostatin In Salmoninae, Nicholas Galt
Stress And Myostatin In Salmoninae, Nicholas Galt
All ETDs from UAB
The relationship between the muscle growth inhibitor, myostatin, and the stress response has been extensively studied in mammals, and myostatin is now known to partially mediate the degradative effects of stress in skeletal muscle. In fish, this relationship has not yet been clearly described. Herein, the effects of two stress mimetics, cortisol treatment and crowding, on myostatin-1a, -1b, and -2a expression in rainbow trout (Oncorhynchus mykiss), cutthroat trout (Oncorhynchus clarki), Chinook salmon (Oncorhynchus tshawytscha), brook trout (Salvelinus fontinalis), and Atlantic salmon (Salmo salar) are described. In study I, no clear effects on myostatin mRNA expression were detected in rainbow trout …