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Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity In Lung Fibroblast And Epithelial Cells, Carla M.T. Bauer, Stephanie J. Dewitte-Orr, Kyle R. Hornby, Caleb C.J. Zavitz, Brian D. Lichty, Martin R. Stämpfli, Karen L. Mossman
Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity In Lung Fibroblast And Epithelial Cells, Carla M.T. Bauer, Stephanie J. Dewitte-Orr, Kyle R. Hornby, Caleb C.J. Zavitz, Brian D. Lichty, Martin R. Stämpfli, Karen L. Mossman
Biology Faculty Publications
The objective of this study was to investigate the impact of cigarette smoke on innate antiviral defense mechanisms; specifically, we examined the effects of cigarette smoke on the induction of type I interferon (IFN). We observed a dose-dependent decrease in the ability of human lung fibroblast and epithelial cells to elicit an antiviral response against a viral double-strand RNA (dsRNA) mimic, polyI:C, in the presence of cigarette smoke-conditioned medium (SCM). Mechanistically, SCM decreases the expression of IFN-stimulated gene 15 (ISG15) and IFN regulatory factor-7 (IRF-7) transcripts and suppresses the nuclear translocation of key transcription factors, nuclear factor-κB (NF-κB) and IRF-3, …
Between-Year Survival And Rank Transitions In Male Black-Capped Chickadees (Poecile Atricapillus): A Multistate Modeling Approach, Kristin A. Schubert, Daniel J. Mennill, Scott M. Ramsay, Ken A. Otter, Laurene M. Ratcliffe, Cornelia Kraus
Between-Year Survival And Rank Transitions In Male Black-Capped Chickadees (Poecile Atricapillus): A Multistate Modeling Approach, Kristin A. Schubert, Daniel J. Mennill, Scott M. Ramsay, Ken A. Otter, Laurene M. Ratcliffe, Cornelia Kraus
Biology Faculty Publications
In dominance-structured animal societies, variation in individual fitness is often related to social status. Like many passerine birds, Black-capped Chickadees (Poecile atricapillus) have a short average adult life-expectancy (Ø2 years); however, the maximum recorded life span is >5× as long. Enhanced annual survival could contribute to greater lifetime reproductive success for male Black-capped Chickadees with high social rank. We used multistate capture–mark–recapture models to estimate annual survival of male Black-capped Chickadees in Ontario using resighting and recapture data collected from 1997 to 2002. Our goal was to evaluate support for an influence of rank on annual survival and …