Digital Commons Network^™

Eyes Open In The Dark, Brittany A. Forrest

Electronic Thesis and Dissertation Repository

An unusual dissertation that presents a science fiction autobiographical narrative, following a trial of trauma and identity dysphoria. Through a trans-queer biological female lens, the vulnerable tone of the author invites the reader into wording that describes matters they will care for on a human level. This study probes the question of what lives within the silence of our perceptions by appraising reverberations between interactions that coerce the human condition. Interrogating memory is inevitable when questioning how defense mechanisms interrelate and adapt to human needs. This study penetrates the complexities of perception fabrications, power dynamics, sensory perceptions, systemic moralities, and …

Cognitive Changes In Early Untreated Parkinson's Disease, Kunj Patel

Electronic Thesis and Dissertation Repository

Cognitive impairment is the most common non-motor symptom in Parkinson’s disease (PD), affecting up to one-third of early-stage patients. However, the cognitive profile in early PD remains unclear due to the use of heterogenous samples of disease severity, small sample sizes, and the inclusion of medication effects. This study aims to characterize cognitive deficits in early PD using a large, drug-naive sample. This study examined performance on the Montreal Cognitive Assessment and the Hopkins Verbal Learning Test from the Parkinson’s Progression Markers Initiative dataset (n= 643 patients with PD; n= 240 healthy controls). Patients were restricted to …

Investigating The Age-Dependent Impact Of Lactate Dehydrogenase On Cognition In Flies And Mice, Ariel Khaya Frame

Electronic Thesis and Dissertation Repository

Lactate is a carbohydrate breakdown product typically produced in astrocytes, a type of glial cell, and transported to neurons within the brain. This type of metabolic coupling is commonly referred to as the astrocyte neuron lactate shuttle (ANLS). While numerous studies have shown that the ANLS is involved in cognition in mammals few have taken into consideration sex differences, changes with age, or evolutionary conservation in invertebrates. Lactate metabolism is controlled by the enzymatic interconversion of pyruvate and lactate in a reaction catalyzed by lactate dehydrogenase (LDH). In this thesis I examined cognitive changes across lifespan affected by genetic manipulation …

Working Memory During The Menstrual Cycle: A Study Of The Role Of The Different Phases Of The Menstrual Cycle On Working Memory, Daniella Brownrigg

Brescia Psychology Undergraduate Honours Theses

This study investigated the role of the menstrual cycle phases (Follicular, Luteal and Menstruation) on working memory components (verbal and visuospatial). Eighty-eight undergraduate students attending Brescia University college completed a survey regarding: demographics, menstrual cycle information and working memory cognitive tasks. The cognitive tasks were the Corsi Block Tapping Test and a shorter version of the Hooper Visual Organization test for visuospatial working memory; and the Forward Digit Span Test and the Semantic Verbal Fluency Subset: Animals from the Barcelona Test for verbal working memory. Participants were categorized into the different menstrual phases they were experiencing. No significant differences were …

'Gave His Life For The Empire': Memory, Memorials, And Identity In The British Empire After The First World War, Bryan Mcclure

Electronic Thesis and Dissertation Repository

This dissertation examines the construction of personal memorials after the First World War across the British Empire nations of the United Kingdom, Ireland, Australia, Canada, and New Zealand, to understand how individuals sought to make their own memorial to remember their loved one killed in the conflict. In comparison to other studies on the construction of national or other community memorials, this dissertation explores how individuals accepted or rejected dominant discourses in creating their own memorials that spoke to how they remembered the war. It is based on a large database of more than 2,000 private memorials to individuals that …

Increased Top-Down Control Of Emotions During Symptom Provocation Working Memory Tasks Following A Rct Of Alpha-Down Neurofeedback In Ptsd., Saurabh Bhaskar Shaw, Andrew A Nicholson, Tomas Ros, Sherain Harricharan, Braeden Terpou, Maria Densmore, Jean Theberge, Paul Frewen, Ruth A Lanius

Department of Medicine Publications

BACKGROUND: Posttraumatic stress disorder (PTSD) has been found to be associated with emotion under-modulation from the prefrontal cortex and a breakdown of the top-down control of cognition and emotion. Novel adjunct therapies such as neurofeedback (NFB) have been shown to normalize aberrant neural circuits that underlie PTSD psychopathology at rest. However, little evidence exists for NFB-linked neural improvements under emotionally relevant cognitive load. The current study sought to address this gap by examining the effects of alpha-down NFB in the context of an emotional n-back task.

METHODS: We conducted a 20-week double-blind randomized, sham-controlled trial of alpha-down NFB and collected …

How The Body Remembers: Examining The Default Mode And Sensorimotor Networks During Moral Injury Autobiographical Memory Retrieval In Ptsd., Breanne E Kearney, Braeden A Terpou, Maria Densmore, Saurabh B Shaw, Jean Theberge, Rakesh Jetly, Margaret C Mckinnon, Ruth A Lanius

Department of Medicine Publications

Neural representations of sensory percepts and motor responses constitute key elements of autobiographical memory. However, these representations may remain as unintegrated sensory and motor fragments in traumatic memory, thus contributing toward re-experiencing and reliving symptoms in trauma-related conditions such as post-traumatic stress disorder (PTSD). Here, we investigated the sensorimotor network (SMN) and posterior default mode network (pDMN) using a group independent component analysis (ICA) by examining their functional connectivity during a script-driven memory retrieval paradigm of (potentially) morally injurious events in individuals with PTSD and healthy controls. Moral injury (MI), where an individual acts or fails to act in a …

Digital Bookplates: Cataloging Processes And Workflows, Alie Visser

Western Libraries Publications

Historically, bookplates were found in the front of print monographs. Transitioning them to digital allows libraries to expand their visibility to researchers and to fundraising activities within institutions. Digital bookplates offer significant opportunities to honor or memorialize individuals with gifts to libraries at varying donation levels. This article discusses digital bookplates in an academic library and provides examples of the cataloging, metadata, and web processes involved in maintaining and collaborating on this active fundraising program. A previous article on this topic was published in 2012 and this article provides an update to its procedures and workflows a decade later.

Cognitive Composites For Genetic Frontotemporal Dementia: Genfi-Cog, Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma Van Der Ende, Esther Van Den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre De Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard

Neuroscience Institute Publications

Background: Clinical endpoints for upcoming therapeutic trials in frontotemporal dementia (FTD) are increasingly urgent. Cognitive composite scores are often used as endpoints but are lacking in genetic FTD. We aimed to create cognitive composite scores for genetic frontotemporal dementia (FTD) as well as recommendations for recruitment and duration in clinical trial design. Methods: A standardized neuropsychological test battery covering six cognitive domains was completed by 69 C9orf72, 41 GRN, and 28 MAPT mutation carriers with CDR® plus NACC-FTLD ≥ 0.5 and 275 controls. Logistic regression was used to identify the combination of tests that distinguished best between each mutation carrier …

At Dusk, Michelle Paterok

Electronic Thesis and Dissertation Repository

In supplement to my Master of Fine Arts thesis exhibition, this dossier is composed of an extended artist statement, photographic documentation of artwork, a transcribed interview with artist Ben Reeves, and a curriculum vitae. These components contextualize the motivation and research that inform my studio work in painting. The extended artist statement describes the personal and theoretical foundation of my Master’s thesis project—a series of paintings collectively titled At Dusk, which documents everyday interior space in order to explore the invocations of colour, light and atmosphere. The interview with Ben Reeves provides insight into his artistic practice in painting, …

Exploring The Structural And Functional Effects Of Pediatric Hydrocephalus On The Hippocampus, Lili Meng

Undergraduate Student Research Internships Conference

Hydrocephalus is one of the most common pediatric neurological problems that requires brain surgery in children. Pediatric hydrocephalus is characterized as an abnormal cerebrospinal fluid (CSF) buildup in the brain’s ventricles due to ineffective CSF reabsorption. When this fluid builds up in these cavities, it increases intracranial pressure and has a direct mass effect on the surrounding brain tissue and structures. Ultimately, various functions are affected including—but not limited to—vision, learning, memory, motor control, and hearing. Despite current literature suggesting that hydrocephalus may be associated with reduced hippocampal volume among rats and human adults, findings remain limited in the human …

Assessing The Impact Of Lipopolysaccharide On Learning And Memory In Rats, Anahat Luthra

Undergraduate Student Research Internships Conference

The immune system and the central nervous system (CNS) have a bi-direction relationship, modulating one another.⁴ Proinflammatory cytokines released from CNS immune cells have an impact on cognitive processes such as learning and memory.¹ Liposaccharide (LPS), a cell wall component of Gram-negative bacteria, which is used to activate proinflammatory cytokine release has been found to impact learning and memory processes, such as in the anticipatory nausea paradigm (ANP).² Anticipatory nausea and vomiting is that which may occur before a chemotherapy treatment session begins in a patient who has had chemotherapy before. It is caused by triggers like …

Familiarity Modulates Neural Tracking Of Sung And Spoken Utterances, Christina M. Vanden Bosch Der Nederlanden, Marc F. Joanisse, Jessica A. Grahn, Tineke M. Snijders, Jan Mathijs Schoffelen

Neuroscience Institute Publications

Music is often described in the laboratory and in the classroom as a beneficial tool for memory encoding and retention, with a particularly strong effect when words are sung to familiar compared to unfamiliar melodies. However, the neural mechanisms underlying this memory benefit, especially for benefits related to familiar music are not well understood. The current study examined whether neural tracking of the slow syllable rhythms of speech and song is modulated by melody familiarity. Participants became familiar with twelve novel melodies over four days prior to MEG testing. Neural tracking of the same utterances spoken and sung revealed greater …

Microglial Inflammation And Cognitive Dysfunction In Comorbid Rat Models Of Striatal Ischemic Stroke And Alzheimer's Disease: Effects Of Antioxidant Catalase-Skl On Behavioral And Cellular Pathology, Jennifer L. Mackenzie, Nadezda Ivanova, Hayley J. Nell, Courtney R. Giordano, Stanley R. Terlecky, Cansu Agca, Yuksel Agca, Paul A. Walton, Shawn N. Whitehead, David F. Cechetto

Neuroscience Institute Publications

Ischemic stroke often co-occurs with Alzheimer's disease (AD) leading to a worsened clinical outcome. Neuroinflammation is a critical process implicated in AD and ischemic pathology, associated with cognitive decline. We sought to investigate the combined effects of ischemic stroke induced by endothelin-1 injection in two AD rat models, using motor function, memory and microglial inflammation in the basal forebrain and striatum as readouts. In addition, we sought to determine the effectiveness of the antioxidant biologic CAT-SKL in one of the models. The early AD model employed the bilateral intracerebroventricular injections of the toxic β-amyloid peptide Aβ25–35, the prodromal AD model …

Thomas Reid On Language And Mind, Alastair L.V. Crosby

Electronic Thesis and Dissertation Repository

The dissertation concerns Thomas Reid’s philosophy of language. In the first three chapters, I discuss his philosophy of language in relation to his developmental psychology. More specifically, I discuss his answers to two questions: (i) what does the ability to understand artificial linguistic signs make possible? and (ii) what makes the ability to understand artificial linguistic signs possible? The focus is on Reid’s claim that the mind’s ability to understand artificial linguistic signs makes it possible for it to acquire a number of distinct mental abilities, such as to conceive universals, to judge, and to reason. I argue this claim …

Kl-Vs Heterozygosity Is Associated With Lower Amyloid-Dependent Tau Accumulation And Memory Impairment In Alzheimer’S Disease, Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Medical Biophysics Publications

Klotho-VS heterozygosity (KL-VShet) is associated with reduced risk of Alzheimer’s disease (AD). However, whether KL-VShet is associated with lower levels of pathologic tau, i.e., the key AD pathology driving neurodegeneration and cognitive decline, is unknown. Here, we assessed the interaction between KL-VShet and levels of beta-amyloid, a key driver of tau pathology, on the levels of PET-assessed neurofibrillary tau in 551 controls and patients across the AD continuum. KL-VShet showed lower cross-sectional and longitudinal increase in tau-PET per unit increase in amyloid-PET when compared to that of non-carriers. This association of KL-VShet on tau-PET was stronger in Klotho mRNA-expressing brain …

The Embroidered Tablecloth: How Locale Influences Eastern European Jewish Textile Production, Elena Solomon

Electronic Thesis and Dissertation Repository

Recent scholarship frames craft as distinct from art and as an encapsulation of cultural expression at a given moment. Building on that framework, this thesis analyzes the shifting attitudes towards the production of handmade textiles among Eastern European Jews in the US in the twentieth century, as influenced by their migration. To demonstrate the textile environment at that time, this thesis examines pre- and post-migration primary sources and autobiographical writing, including Mary Antin’s The Promised Land, supplemented with interviews of first- and second-generation immigrants to Chicago. In contrast with stereotypes about craft as historically stable, defining craft as regional …

Sustained Neural Activity Correlates With Rapid Perceptual Learning Of Auditory Patterns, Björn Herrmann, Kurdo Araz, Ingrid S. Johnsrude

Brain and Mind Institute Researchers' Publications

Repeating structures forming regular patterns are common in sounds. Learning such patterns may enable accurate perceptual organization. In five experiments, we investigated the behavioral and neural signatures of rapid perceptual learning of regular sound patterns. We show that recurring (compared to novel) patterns are detected more quickly and increase sensitivity to pattern deviations and to the temporal order of pattern onset relative to a visual stimulus. Sustained neural activity reflected perceptual learning in two ways. Firstly, sustained activity increased earlier for recurring than novel patterns when participants attended to sounds, but not when they ignored them; this earlier increase mirrored …

Memoir Dataset: Quantifying Image Memorability In Adolescents, Gal Almog, Yalda Mohsenzadeh

Undergraduate Student Research Internships Conference

Every day, humans observe and interact with hundreds of images and scenes; whether it be on a cellphone, on television, or in print. Yet a vast majority of these images are forgotten, some immediately and some after variable lengths of time. Memorability is indeed a property intrinsic to all images that can be extracted, as well as predicted. While memory itself is a process that occurs in the brain of an individual, the concept of memorability is an intrinsic, continuous property of a stimulus that can be both measured and manipulated. We selected images from the MemCat data set that …

How Long Does It Take For A Voice To Become Familiar? Speech Intelligibility And Voice Recognition Are Differentially Sensitive To Voice Training, Emma Holmes, Grace To, Ingrid S. Johnsrude

Communication Sciences and Disorders Publications

When people listen to speech in noisy places, they can understand more words spoken by someone familiar, such as a friend or partner, than someone unfamiliar. Yet we know little about how voice familiarity develops over time. We exposed participants (N = 50) to three voices for different lengths of time (speaking 88, 166, or 478 sentences during familiarization and training). These previously heard voices were recognizable and more intelligible when presented with a competing talker than novel voices—even the voice previously heard for the shortest duration. However, recognition and intelligibility improved at different rates with longer exposures. Whereas recognition …

Spinoza On Language, Luis Ramos-Alarcón

Western Ontario Early Modern Philosophy (WOEMP) Online Events

Some scholars have understood that Spinoza’s extreme rationalism, nominalism, conventionalism, and rejection of a semantic theory of truth make his philosophy incapable to use language for philosophical and scientific purposes; insofar he considered language a source of inadequate knowledge, falsity, and error. Thus Spinoza finds contradiction in his inevitable use of language to express his philosophy. This paper has four aims: first, propose an explanation on why language is inadequate knowledge for Spinoza; second, present differences between inadequacy, falsity, and error in language; third, argue on the Spinozian use of the geometrical method as a solution for the adequate use …

Still, Unfolding, Ramolen Mencero Laruan

Electronic Thesis and Dissertation Repository

Together with my Master of Fine Art thesis exhibition, still, unfolding, at Zalucky Contemporary (Toronto, Ontario), this dossier constitutes the following accompanying components: a comprehensive artist statement, documented artwork, an interview with artist Erika DeFreitas, and a curriculum vitae. These components contextualize my subject-position, and outline theoretical research, motivations, and reflections that drive my work. I expand on the diasporic experience, politics of knowledge, and the autobiographical genre as they are linked methodologies in the retrieval of immigrant histories. The fusion of autobiography and fiction becomes a hopeful approach in challenging forgotten or omitted history and confronts the expectations …

Is Social Rank Correlated With Cognitive Ability In Black-Capped Chickadees?, Gloria Hyun Young Cho

Electronic Thesis and Dissertation Repository

Traditionally, dominant animals have been regarded as better competitors in all aspects of life, including cognition. However, the survival and reproductive advantages of being a dominant chickadee are surprisingly modest. It is possible that subordinate individuals compensate for the disadvantages of a lower rank with better cognitive abilities. If dominants are monopolizing prime food sources, subordinates may have developed better associative learning skills by learning to associate novel types of stimuli with food rewards. In this thesis, I asked whether dominance rank is correlated with cognitive ability in Black-capped Chickadees. I determined dominance rank in six flocks of six chickadees, …

The Role Of Histone Demethylases In Learning And Memory In The Mushroom Body Of Drosophila Melanogaster, Crystal Keung

Electronic Thesis and Dissertation Repository

Intellectual disability (ID) is a neurodevelopmental disorder associated with many epigenetic regulators and chromatin modifying enzymes like histone lysine methyltransferases (KMTs) and demethylases (KDMs). Here, I systematically investigate the role of 7 KDMs: Su(var)3-3, KDM2, Lid, CG2982, UTX, KDM4B, JHDM2, and 1 KMT: trr in the context of learning and memory using Drosophila melanogaster. Genetic knockdown of each gene in the mushroom body (MB) of flies are tested for short- and long-term memory impairment using courtship conditioning. Knockdown of 6 KDMs and trr resulted in memory loss. MB morphology was analyzed to determine potential cause of memory loss. …

Formation Of Implicit Memories From A Narrative Played During Sleep, Amanat Ludhar

Undergraduate Honors Theses

Though, it was previously thought that the sleeping brain was dormant, research suggests that participants can process salient stimuli and form implicit memories of simple stimuli (e.g. words) during sleep. Thus, the current study aimed to determine whether participants could form implicit memories of a narrative played during sleep, and what role different sleep stages played in this memory formation. Participants were played a story while taking a nap, and EEG was used to track time spent in different sleep stages. Later, participants completed an implicit memory task where they were asked to differentiate between animal and non-animal words through …

Memory Function And Brain Functional Connectivity Adaptations Following Multiple-Modality Exercise And Mind–Motor Training In Older Adults At Risk Of Dementia: An Exploratory Sub-Study, Narlon C. Boa Sorte Silva, Lindsay S. Nagamatsu, Dawn P. Gill, Adrian M. Owen, Robert J. Petrella

BrainsCAN Publications

© Copyright © 2020 Boa Sorte Silva, Nagamatsu, Gill, Owen and Petrella. Background: Multiple-modality exercise improves brain function. However, whether task-based brain functional connectivity (FC) following exercise suggests adaptations in preferential brain regions is unclear. The objective of this study was to explore memory function and task-related FC changes following multiple-modality exercise and mind–motor training in older adults with subjective cognitive complaints. Methods: We performed secondary analysis of memory function data in older adults [n = 127, mean age 67.5 (7.3) years, 71% women] randomized to an exercise intervention comprised of 45 min of multiple-modality exercise with additional 15 min …

Exploring Cognitive Maps Through Sketching, Melissa M. Nantais

Electronic Thesis and Dissertation Repository

Abstract

Periodic testing has been found to improve the accuracy of participants’ cognitive maps when an onscreen map is provided, however, it is unclear whether the same results would occur without the onscreen map. The current study investigated whether drawing a map periodically while exploring the virtual environment Silcton would improve cognitive map accuracy. Participants explored Silcton and were stopped every 4 minutes to either sketch a map of Silcton, identify items seen in Silcton, or colour an unrelated picture, and a baseline group was not stopped. All groups drew a final sketch map and completed a direction estimation task. …

Sanaugavut: Art From Kinngait, Nakasuk Alariaq

Electronic Thesis and Dissertation Repository

“Sanaugavut: Art from Kinngait” explores 20^th century Inuit art from an Inuk’s perspective to highlight the work Inuit participants contributed to in the development of commercialized art production in the North. The author Nakasuk Alariaq is from Kinngait (Cape Dorset) and is the first Inuk graduate student at Western University to be offered space within the university’s formal settings to curate an Inuit art exhibition. This exhibition and thesis go hand in hand and are therefore very important to advocates of Indigenous self-representation in academia and in galleries. The exhibition “Sanaugavut: Art from Kinngait” was …

Thirty-Five Years Of Computerized Cognitive Assessment Of Aging — Where Are We Now?, Avital Sternin, Alistair Burns, Adrian M. Owen

Brain and Mind Institute Researchers' Publications

Over the past 35 years, the proliferation of technology and the advent of the internet have resulted in many reliable and easy to administer batteries for assessing cognitive function. These approaches have great potential for affecting how the health care system monitors and screens for cognitive changes in the aging population. Here, we review these new technologies with a specific emphasis on what they offer over and above traditional ‘paper-and-pencil’ approaches to assessing cognitive function. Key advantages include fully automated administration and scoring, the interpretation of individual scores within the context of thousands of normative data points, the inclusion of …

Investigating The Role Of Atrx In Glutamatergic Hippocampal Neurons, Renee Tamming

Electronic Thesis and Dissertation Repository

Mutations in ATRX, a Snf2-type chromatin remodeler, frequently lead to intellectual disability. However, the function of ATRX within the brain in cognition and synaptic transmission are incompletely understood. The aim of this study was to investigate the role of ATRX in the adult mouse brain. While complete loss of ATRX in the embryonic mouse brain results in perinatal lethality, mosaic expression of ATRX stunted growth and perturbed circulating IGF-1 levels. Mosaic expression of ATRX also impaired adult cognition, specifically recognition memory and spatial learning and memory. However, there were confounding factors that led me to a new model in …