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Mapping The Subcortical Connectome Using In Vivo Diffusion Mri: Feasibility And Reliability, Jason Kai, Ali R. Khan, Roy Am Haast, Jonathan C. Lau
Mapping The Subcortical Connectome Using In Vivo Diffusion Mri: Feasibility And Reliability, Jason Kai, Ali R. Khan, Roy Am Haast, Jonathan C. Lau
Neuroscience Institute Publications
Tractography combined with regions of interest (ROIs) has been used to non-invasively study the structural connectivity of the cortex as well as to assess the reliability of these connections. However, the subcortical connectome (subcortex to subcortex) has not been comprehensively examined, in part due to the difficulty of performing tractography in this complex and compact region. In this study, we performed an in vivo investigation using tractography to assess the feasibility and reliability of mapping known connections between structures of the subcortex using the test-retest dataset from the Human Connectome Project (HCP). We further validated our observations using a separate …
An In Vivo Investigation Of Short-Ranged Structural Connectivity In The Human Brain, Jason Kai
An In Vivo Investigation Of Short-Ranged Structural Connectivity In The Human Brain, Jason Kai
Electronic Thesis and Dissertation Repository
Short-ranged connectivity comprise the majority of connections throughout the brain, joining together nearby regions and contributing to important networks that facilitate complex function and cognition. Despite constituting the majority of white matter in the brain and their importance, studies examining short-ranged connections have thus far been limited in part due to the challenges associated with identifying and validating them. Tractography, a computational technique for reconstructing axon trajectories from diffusion magnetic resonance imaging, has been commonly used to identify and study major white connections (e.g. corticospinal tract), which are easier to identify relative to the short-ranged connections. The use of additional …
Three-Dimensional Ultrasound Imaging For Characterization Of Synovitis In First Carpometacarpal Osteoarthritis, Carla Du Toit
Three-Dimensional Ultrasound Imaging For Characterization Of Synovitis In First Carpometacarpal Osteoarthritis, Carla Du Toit
Electronic Thesis and Dissertation Repository
First carpometacarpal osteoarthritis is one of the most common forms of OA and is a significant source of pain and disability for patients. Discrepancies between traditional imaging modalities and patient reported outcomes have led galvanized researchers to developing objective point of care based imaging tools for assessing OA progression and treatment response. This thesis aims to describe the development and validation of a semi-submerged mechanical three-dimensional ultrasound device against magnetic resonance imaging. The validation of the 3D US device was conducted on a series of imaging phantoms, as well as ten CMC1 OA patients. Two-raters manually segmented areas of synovial …
Reliability, Reproducibility, And Advantages Of Measuring Carotid Total Plaque Area, M. Reza Azarpazhooh, Ellisiv Mathiesen, Tatjana Rundek, Michel Romanens, Ansgar Adams, Luis Armando, Hernan Perez, Hugo Villafañe, Nestor H. Garcia, Borja Ibañez, Chrysi Bogiatzi, Reza Tabrizi, Valentín Fuster, J. David Spence
Reliability, Reproducibility, And Advantages Of Measuring Carotid Total Plaque Area, M. Reza Azarpazhooh, Ellisiv Mathiesen, Tatjana Rundek, Michel Romanens, Ansgar Adams, Luis Armando, Hernan Perez, Hugo Villafañe, Nestor H. Garcia, Borja Ibañez, Chrysi Bogiatzi, Reza Tabrizi, Valentín Fuster, J. David Spence
Neuroscience Institute Publications
No abstract provided.
The Natural History Of Modic Changes - A 5- And 15-Year Follow-Up Study, Parnian Saremi
The Natural History Of Modic Changes - A 5- And 15-Year Follow-Up Study, Parnian Saremi
Electronic Thesis and Dissertation Repository
Modic changes (MCs), defined as bone marrow lesions adjacent to the vertebral endplate seen on MRI, have been associated with back pain. There are different types of MCs, with different histopathological correlates. This community-based study sample comprised 110 men from the Twin Spine Study, with baseline, 5-year, and 15-year follow-up MRIs. Following training and reliability testing, 1320 endplates (T12-S1) were evaluated for MC presence, type, and dimensions at each time point. Results demonstrated that Type 2 Modic Changes (MC2) were the most common type, with approximately half located at the two lowest disc levels. However, Type 1 Modic Changes (MC1) …
Assessing The Reliability Of Template-Based Clustering For Tractography In Healthy Human Adults, Jason Kai, Ali R. Khan
Assessing The Reliability Of Template-Based Clustering For Tractography In Healthy Human Adults, Jason Kai, Ali R. Khan
Neuroscience Institute Publications
Tractography is a non-invasive technique to investigate the brain’s structural pathways (also referred to as tracts) that connect different brain regions. A commonly used approach for identifying tracts is with template-based clustering, where unsupervised clustering is first performed on a template in order to label corresponding tracts in unseen data. However, the reliability of this approach has not been extensively studied. Here, an investigation into template-based clustering reliability was performed, assessing the output from two datasets: Human Connectome Project (HCP) and MyConnectome project. The effect of intersubject variability on template-based clustering reliability was investigated, as well as the reliability of …
Assessment Of Tropical Cyclone Wind And Wave Hazards And Their Effect On The Reliability Of Wind Turbines, Chao Sheng
Assessment Of Tropical Cyclone Wind And Wave Hazards And Their Effect On The Reliability Of Wind Turbines, Chao Sheng
Electronic Thesis and Dissertation Repository
Tropical cyclone (TC) induces strong winds, heavy rainfalls, and storm surge. They cause fatalities and property damages, especially in the coastal regions that are prone to TC hazards. The TC wind or wave assessments were reported in the literature. The assessment provides the required hazard characterizations for assessing the reliability and risk of structures such as onshore and offshore wind turbines (WTs). The present study considered sites near the coastline of mainland China. It is focused on 1) the assessment of using different historical best-track datasets on the development of stochastic TC track models and on the estimated TC wind …
Overprotection And Overcontrol In Childhood: An Evaluation On Reliability And Validity Of 33-Item Expanded Childhood Trauma Questionnaire (Ctq-33), Chinese Version, Zhipeng Wu, Zhening Liu, Zhengqian Jiang, Xingzi Fu, Qian Deng, Lena Palaniyappan, Zhibiao Xiang, Danqing Huang, Yicheng Long
Overprotection And Overcontrol In Childhood: An Evaluation On Reliability And Validity Of 33-Item Expanded Childhood Trauma Questionnaire (Ctq-33), Chinese Version, Zhipeng Wu, Zhening Liu, Zhengqian Jiang, Xingzi Fu, Qian Deng, Lena Palaniyappan, Zhibiao Xiang, Danqing Huang, Yicheng Long
Neuroscience Institute Publications
Overprotection and overcontrol from parents or other family members, which are not rare in the Chinese culture, have been suggested to be traumatic experiences for some children. However, research on overprotection/overcontrol is much rarer in China compared with other childhood trauma subtypes. One of the possible reasons for this is the lack of easy and feasible screening tools. In this study, we therefore translated and validated a Chinese version of the 33-item Childhood Trauma Questionnaire (CTQ-33), which was expanded from the widely-used 28-item CTQ with an additional overprotection/overcontrol subscale. A total of 248 young healthy participants were recruited and completed …