Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Plasma Homocyst(E)Ine Concentration, But Not Mthfr Genotype, Is Associated With Variation In Carotid Plaque Area, J. David Spence, M. Rene Malinow, Peter A. Barnett, Ali J. Marian, David Freeman, Robert A. Hegele
Plasma Homocyst(E)Ine Concentration, But Not Mthfr Genotype, Is Associated With Variation In Carotid Plaque Area, J. David Spence, M. Rene Malinow, Peter A. Barnett, Ali J. Marian, David Freeman, Robert A. Hegele
Department of Medicine Publications
Background and Purpose - Elevated plasma homocyst(e)ine [H(e)] concentration is associated with premature atherosclerosis. A common cause of elevated plasma H(e) concentration is a thermolabile mutation (677T) in the gene encoding methylenetetrahydrofolate reductase (MTHFR). We sought to determine whether plasma H(e) concentration or MTHFR genotype would be more strongly associated with carotid plaque area (CPA), a potential intermediate phenotype of atherosclerosis. Methods - In 307 subjects who were ascertained through a premature atherosclerosis clinic, we measured CPA with 2- dimensional ultrasound and also determined traditional atherosclerosis risk factors, in addition to plasma H(e) concentration and MTHFR genotypes. Results - We …