Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
P53-Dependent Tumorigenesis And Gene Expression In Mammalian Brain, Meyel Donald Van
P53-Dependent Tumorigenesis And Gene Expression In Mammalian Brain, Meyel Donald Van
Digitized Theses
Astrocytic gliomas are the most common brain cancers of adults. The goal of this research was to examine the molecular genetic determinants of gliomas, with particular emphasis on the tumor suppressor gene P53. First, I studied the frequency, nature and timing of P53 mutations in human gliomas. I observed that glioma-prone families do not have inherited mutations of P53, nor of the Nf1-GRD, Nf2, MTS1, MTS2, or CDK4 genes. However, a high frequency of loss of heterozygosity at chromosome 9p was noted in gliomas that cluster in families. In a second study of low-grade gliomas that progressed to higher grade …
The Antioxidant Enzymes (Superoxide Dismutase, Catalase And Glutathione Peroxidase): Their Molecular Evolution And Regulation In Mice, Nicholas Joseph Schisler
The Antioxidant Enzymes (Superoxide Dismutase, Catalase And Glutathione Peroxidase): Their Molecular Evolution And Regulation In Mice, Nicholas Joseph Schisler
Digitized Theses
Reactive, oxygen derived free radicals are detoxified by an enzymatic pathway RA-5 which includes the enzymes superoxide dismutase (CuZn and Mn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). In an effort to understand the molecular evolution and antiquity of these enzymes, comparative techniques were developed for identification and visualization of protein family relationships. Analysis of amino acid sequence data indicated that these enzymes had expected phylogenetic relationships and that the two SOD enzymes were evolutionarily convergent. Multiple sequence alignments of the SOD, CAT and GSH-Px families of proteins were represented quantitatively and used to probe the Swiss-PROT database for proteins …