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Examining The Role Of Chloride Homeostasis And Pge2 Signaling In The Neuroendocrine Stress Response To Inflammation, Samuel A. Mestern
Examining The Role Of Chloride Homeostasis And Pge2 Signaling In The Neuroendocrine Stress Response To Inflammation, Samuel A. Mestern
Electronic Thesis and Dissertation Repository
The brain senses inflammatory signals and drives the release of glucocorticoids (GCs) — potent immunosuppressants — via the activation of the hypothalamic-pituitary-adrenal (HPA) axis. This inflammation-induced HPA axis activation is largely mediated by prostaglandin E2 (PGE2), acting on two subtypes of the PGE2 receptor, EP1 and EP3. Recently, our group revealed EP3 signaling mechanisms that excite HPA axis regulatory neurons. This thesis sought to tease out the remaining EP1 signaling mechanisms. Considering that the excitability of HPA axis regulatory neurons is constrained by GABAA receptor-mediated synaptic inhibition that relies on low-level intracellular Cl-. We hypothesized that PGE2-EP1 …
Debt And Stress Amongst Orthodontic Residents, Timothy Renison
Debt And Stress Amongst Orthodontic Residents, Timothy Renison
Electronic Thesis and Dissertation Repository
Background: The cost of education to become an orthodontist has increased significantly over recent years which has led to an increase in debt of graduating orthodontists.
Aim: This paper aims to assess whether debt amongst orthodontic residents in North America is associated with their stress levels, attitudes towards debt, financial literacy and mathematics anxiety.
Materials and Methods: Web-based software was used to fabricate a questionnaire, based on previously validated scales, in which respondents were asked questions regarding their debt levels, stress levels, attitudes towards debt, financial literacy and math anxiety.
Results: A total of 101 orthodontic residents completed the online …