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Applications Of Hair As A Record Of Systemic Exposure To Cortisol, Jeffrey Matthew Levine
Applications Of Hair As A Record Of Systemic Exposure To Cortisol, Jeffrey Matthew Levine
Electronic Thesis and Dissertation Repository
Hair cortisol content (HCC) is a novel biomarker that uniquely captures retrospective systemic cortisol exposure. This thesis aimed to assess how different hair growth rates effect HCC timelines in Cushing’s and Addison’s patients, investigate the relationship between HCC and age, puberty, sex and BMI in healthy children and adolescents, and assess novel methods to improve cortisol extraction and recovery. Retrospective HCC timelines derived from a 0.75 cm/month growth rate best matched 50% of patients’ medical records rather than the historically assumed 1 cm/month. HCC correlated positively with age (p<0.0001), puberty status (p<0.001), and BMI (p<0.01) in males and females 7-17 years old. Nitrogen evaporation resulted in greater cortisol recovery than air evaporation (p=0.0003), and hair digestion using NaOH resulted in more rapid extraction of cortisol. These results provide incremental improvements to previous methods and assumptions for HCC analysis and elucidate normal HCC changes in children and adolescents.
High Frequency Oscillations Are Phase-Amplitude Coupled In Stress Induced Seizures Following Traumatic Brain Injury, Paul Jung
Electronic Thesis and Dissertation Repository
Traumatic Brain Injury (TBI) often leads to the development of epilepsy, especially with the occurrence of stressful events. Stressors increase the levels of corticotropin-releasing factor (CRF) in the amygdala, which can be damaged by the secondary effects of TBI. It is hypothesized that the activity of CRF receptor type 1 (CRFR1) in the amygdala is altered post-TBI and supports the generation of epileptiform waves, namely high-frequency oscillations (HFOs). Sprague-Dawley rats were given a moderate TBI and in vivo recordings of the amygdala were taken during the administration of an acute tail pinch stressor. The stressor increased broadband activity …
Weathering The Storm: Physiological And Behavioural Responses Of White-Throated Sparrows To Inclement Weather Cues, Andrea C. Boyer
Weathering The Storm: Physiological And Behavioural Responses Of White-Throated Sparrows To Inclement Weather Cues, Andrea C. Boyer
Electronic Thesis and Dissertation Repository
Changes in weather patterns and extreme weather events are becoming more common with the onset of climate change. This predicted increase in severe weather globally is alarming and it draws concern for the adaptability and ultimate survival of many species. It is clear that birds are able to cope with and respond to inclement weather with physiological and behavioural responses in many circumstances, but as environmental conditions become more severe, the adaptive coping responses of many species may be pushed to their limit. As such, it is important to understand the effects that such changes in environmental conditions will have …
Perfectionism And Burnout In University Students: The Influence Of Resilience, Laura M. Ulrich
Perfectionism And Burnout In University Students: The Influence Of Resilience, Laura M. Ulrich
Brescia Psychology Undergraduate Honours Theses
This study investigated the relationship between perfectionism, resilience, and risk of burnout among university students. The sample consisted of 55 (53 female and two male) Psychology 1000 students from Brescia University College. Self-report questionnaires assessed perfectionism, academic resilience, risk of academic burnout, and perceived stress. Participants were divided into four perfectionism groups: non-perfectionism, pure personal standards perfectionism, pure evaluative concerns perfectionism, and mixed perfectionism. Participants were also divided into a high and low academic resilience group. Individuals with pure personal standards perfectionism had a significantly lower risk of academic burnout compared to those with non-perfectionism, pure evaluative concerns perfectionism, and …
Uncovering A Mystery Of The Isoflavonoid Metabolon: Identification And Characterization Of The Arogenate Dehydratase Gene Family In Soybean, Kelsey Pannunzio
Uncovering A Mystery Of The Isoflavonoid Metabolon: Identification And Characterization Of The Arogenate Dehydratase Gene Family In Soybean, Kelsey Pannunzio
Electronic Thesis and Dissertation Repository
Soybean (Glycine max) is a vastly important, multi-billion dollar global commodity; but this crop’s yields are under threat from the pathogen Phytophthora sojae, which causes extensive stem and root rot in soybean crops. Isoflavonoids, a metabolite class unique to legumes, are a promising research target to combat P. sojae. Isoflavonoids are released as phytoalexins in response to stress, and also facilitate interactions with nitrogen-fixing rhizobial bacteria through nodule formation. An isoflavonoid biosynthesis metabolon was discovered in soybean through co-immunoprecipitation, anchored to the endoplasmic reticulum by isoflavone synthase (IFS) and Cinnamate 4-hydroxylase, two cytochrome P450 enzymes. One of the …