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Effect Of Bacterial Superantigens On The Magnitude And Breadth Of Influenza-Specific Cd8+ T Cell Responses, Courtney Meilleur Dec 2018

Effect Of Bacterial Superantigens On The Magnitude And Breadth Of Influenza-Specific Cd8+ T Cell Responses, Courtney Meilleur

Electronic Thesis and Dissertation Repository

Severe cases of influenza A virus (IAV) infection are often complicated by concomitant bacterial pneumonia or sepsis. Many bacterial species are capable of producing potent immunomodulators called superantigens (SAgs), which have the potential to interfere with cell-based antiviral immune mechanisms. I asked what effects bacterial SAgs have on both the magnitude and the breadth of antiviral CD8+ T cell (TCD8+) responses. Surprisingly, administration of SAgs to mice shortly before or after vaccination with IAV increased the number of primary TCD8+ responding to select IAV-derived epitopes. T cell receptor staining of these SAg-augmented populations revealed expression of …


The Effects Of Perceived Predation Threat On Stress Response And Memory In Birds, Chlöe S. N. Carter Oct 2018

The Effects Of Perceived Predation Threat On Stress Response And Memory In Birds, Chlöe S. N. Carter

Electronic Thesis and Dissertation Repository

This study examined how perception of predator cues, across three sensory modalities, affects physiology and behaviour of songbirds. I hypothesized that the perception of predator threat would elicit physiological and behavioural responses in both acute and chronic exposure conditions. My first study examined the responses of wild-caught black-capped chickadees (Poecile atricapillus) and house sparrows (Passer domesticus), as well as lab-bred zebra finches (Taeniopygia guttata), to acute predation cue exposure by coding video recorded behaviour and corticosterone analysis. My second study examined changes in black-capped chickadees’ foraging behaviour and memory retention after chronic exposure to …


Unsettling The Homeland: Fragments Of Home And Homeland Among Iraqi Exiles In Amman, Jordan, Abdulla Majeed Apr 2018

Unsettling The Homeland: Fragments Of Home And Homeland Among Iraqi Exiles In Amman, Jordan, Abdulla Majeed

Electronic Thesis and Dissertation Repository

For the past 30 years, imperial military invasions and political meddling in Iraq, and a long history of a repressive Ba’athist regime disfigured the nation, displaced Iraqis from their homeland, and unsettled their relationship to it. By examining the narratives of Iraqi exiles who have diverse migration genealogies, socioeconomic backgrounds, and political trajectories in Amman, Jordan, this thesis looks at how exile shapes how the homeland is imagined, remembered, and performed. Based on fieldwork and interviews conducted in Amman between May and September of 2017, the thesis explores: 1) Why certain narratives and elements of the past are employed, while …