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Corticotropin Releasing Factor Receptor Type 1 Signaling In Epilepsy And Traumatic Brain Injury, V V Chakravarthi Narla
Corticotropin Releasing Factor Receptor Type 1 Signaling In Epilepsy And Traumatic Brain Injury, V V Chakravarthi Narla
Electronic Thesis and Dissertation Repository
Stress increases the frequency by which epileptic seizures occur. Corticotropin-releasing factor (CRF) coordinates neuroendocrine, autonomic and behavioral response to stress. This thesis sought to study the cellular and molecular mechanisms by which CRF regulates the activity of neural circuits in the piriform cortex (PC) in normal and epileptic states. The PC is richly innervated by CRF and 5-HT containing axons arising from the central amygdala and raphe nucleus. CRFR1 and 5-HT2A/CRs have been shown to interact in a manner where CRFR activation subsequently potentiates the activity of 5-HT2A/CRs. The first purpose of this thesis was …
Characterizing The Role Of The Neuropeptide Y-Y5r System In Breast Cancer, Jenna Kara
Characterizing The Role Of The Neuropeptide Y-Y5r System In Breast Cancer, Jenna Kara
Electronic Thesis and Dissertation Repository
Studies have demonstrated a correlation between stress and an increased risk of breast cancer. Neuropeptide Y (NPY) is up- regulated in chronic stress and induces proliferation and chemotaxis of 4T1 breast cancer cells via Y5 receptor (Y5R) activation. In the studies performed in this thesis, we characterize NPY-Y5R as a regulatory system that promotes breast cancer metastasis. We compared three cancer cell sublines derived from the same murine mammary fat pad tumour, that greatly differ in metastatic potential (67NR, 168FARN, and 4T1) in addition to a 4T1-Y5R knockdown established in our labs. In this thesis we demonstrate significance of up-regulation …
The Effects Of Self-Care Meditation Behaviour On Undergraduate Students’ Reported Stress, Anna Smallwood
The Effects Of Self-Care Meditation Behaviour On Undergraduate Students’ Reported Stress, Anna Smallwood
Undergraduate Honours Theses
The goal of this research study was to provide undergraduate post-secondary students with a self-care behaviour that: a) was self-help based; b) could become a routine part of their schedules; and c) was effective in lowering their stress responses. One group of participants was asked to rate their stress on a 7-point scale, twice a day, for 10 business days. A second group of participants was also asked to rate their stress following the same instructions however they were also asked to perform a 5-minute mindfulness-based meditation twice a day, immediately following the stress ratings. A 2 (Week 1 vs. …